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  1. Cognitive impairment is an increasingly recognized comorbidity of diabetes, yet the mechanisms underlying this association remain poorly understood. This knowledge gap has contributed to conflicting findings r...

    Authors: Jiangbo Cui, Caroline Robert, Chia May Teh, Eddie Chong Jun Yi, Joyce R. Chong, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Mitchell K. P. Lai, Christopher Chen and Saima Hilal
    Citation: Alzheimer's Research & Therapy 2024 16:214
  2. The approval of lecanemab, an anti-amyloid therapy for Alzheimer’s disease (AD), necessitates addressing healthcare preparedness for disease-modifying treatment (DMT) to ensure appropriate, safe, and sustainab...

    Authors: Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Atsushi Iwata, Kazushi Suzuki, Kiyotaka Nemoto, Tetsuaki Arai, Shinji Higashi, Ataru Igarashi, Kensaku Kasuga, Shuichi Awata and Takeshi Iwatsubo
    Citation: Alzheimer's Research & Therapy 2024 16:205
  3. Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder with a global impact, yet its pathogenesis remains poorly understood. While age, metabolic abnormalities, and accumulation of neurotoxic su...

    Authors: Lingqi Meng, Han Jin, Burak Yulug, Ozlem Altay, Xiangyu Li, Lutfu Hanoglu, Seyda Cankaya, Ebru Coskun, Ezgi Idil, Rahim Nogaylar, Ahmet Ozsimsek, Saeed Shoaie, Hasan Turkez, Jens Nielsen, Cheng Zhang, Jan Borén…
    Citation: Alzheimer's Research & Therapy 2024 16:213
  4. Glucagon-like peptide-1 receptor agonists are a viable option for the prevention of Alzheimer’s disease (AD) but the mechanisms of this potential disease modifying action are unclear. We investigated the effec...

    Authors: Ivan Koychev, Graham Reid, Maggie Nguyen, Robert J. Mentz, Dan Joyce, Svati H. Shah and Rury R. Holman
    Citation: Alzheimer's Research & Therapy 2024 16:212
  5. Recent magnetic resonance imaging (MRI) studies have established that brain iron accumulation might accelerate cognitive decline in Alzheimer’s disease (AD) patients. Both normal aging and AD are associated wi...

    Authors: Rui Li, Yi‑Ren Fan, Ying-Zhe Wang, He‑Yang Lu, Pei-Xi Li, Qiang Dong, Yan-Feng Jiang, Xing-Dong Chen and Mei Cui
    Citation: Alzheimer's Research & Therapy 2024 16:211
  6. Cholinesterase inhibitors (ChEIs) are prescribed for Alzheimer’s disease (AD) and sometimes for mild cognitive impairment (MCI) without knowing underlying pathologies and its effect on cognition. We investigat...

    Authors: Jung-Min Pyun, Young Ho Park, Min Ju Kang and SangYun Kim
    Citation: Alzheimer's Research & Therapy 2024 16:210
  7. Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development ...

    Authors: Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter and Soumya Palliyil
    Citation: Alzheimer's Research & Therapy 2024 16:209
  8. Apolipoprotein E (APOE) genotypes have been suggested to influence cognitive impairment and clinical onset in presenilin-1 (PSEN1) E280A carriers for autosomal dominant Alzheimer’s disease (ADAD). Less is known a...

    Authors: Stephanie Langella, Kyra Bonta, Yinghua Chen, Yi Su, Daniel Vasquez, David Aguillon, Natalia Acosta-Baena, Ana Y. Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos-Romenets, Claudia Guzman-Martínez, Jeremy J. Pruzin, Valentina Ghisays…
    Citation: Alzheimer's Research & Therapy 2024 16:208
  9. Several blood-based biomarkers offer the opportunity of in vivo detection of brain pathology and neurodegeneration in Alzheimer disease with high specificity and sensitivity, but the performance of amyloid-β (...

    Authors: Charlotte Johansson, Steinunn Thordardottir, José Laffita-Mesa, Josef Pannee, Elena Rodriguez-Vieitez, Henrik Zetterberg, Kaj Blennow and Caroline Graff
    Citation: Alzheimer's Research & Therapy 2024 16:207
  10. Previous research on the risk of dementia associated with education attainment, smoking status, and alcohol use disorder (AUD) has yielded inconsistent results, indicating potential heterogeneous treatment eff...

    Authors: Huilin Tang, C. Elizabeth Shaaban, Steven T. DeKosky, Glenn E Smith, Xia Hu, Michael Jaffee, Ramzi G. Salloum, Jiang Bian and Jingchuan Guo
    Citation: Alzheimer's Research & Therapy 2024 16:206
  11. The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer’s disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.

    Authors: Anika Wuestefeld, Alexa Pichet Binette, Danielle van Westen, Olof Strandberg, Erik Stomrud, Niklas Mattsson-Carlgren, Shorena Janelidze, Ruben Smith, Sebastian Palmqvist, Hannah Baumeister, David Berron, Paul A. Yushkevich, Oskar Hansson, Nicola Spotorno and Laura E.M. Wisse
    Citation: Alzheimer's Research & Therapy 2024 16:204
  12. The mechanistic effects of gamma transcranial alternating current stimulation (tACS) on hippocampal gamma oscillation activity in Alzheimer’s Disease (AD) remains unclear. This study aimed to clarify beneficia...

    Authors: Yi Tang, Yi Xing, Liwei Sun, Zhibin Wang, Changming Wang, Kun Yang, Wei Zhu, Xinrui Shi, Beijia Xie, Yunsi Yin, Yingxin Mi, Tao Wei, Renjie Tong, Yuchen Qiao, Shaozhen Yan, Penghu Wei…
    Citation: Alzheimer's Research & Therapy 2024 16:203
  13. Plasma neurofilament light chain (NfL) is a blood biomarker of neurodegeneration, including Alzheimer’s disease. However, its usefulness may be influenced by common conditions in older adults, including amyloi...

    Authors: Keun You Kim, Eosu Kim and Jun-Young Lee
    Citation: Alzheimer's Research & Therapy 2024 16:202
  14. The term rapidly progressive dementia (RPD) with Lewy bodies (rpDLB) is used for DLB patients who develop a rapidly progressive neurological syndrome and have reduced survival. Here, we characterise the clinic...

    Authors: Giuseppe Mario Bentivenga, Simone Baiardi, Andrea Mastrangelo, Edoardo Ruggeri, Angela Mammana, Alice Ticca, Marcello Rossi, Sabina Capellari and Piero Parchi
    Citation: Alzheimer's Research & Therapy 2024 16:201
  15. Synaptic dysfunction, characterized by synapse loss and structural alterations, emerges as a prominent correlate of cognitive decline in Alzheimer’s disease (AD). Actin cytoskeleton, which serves as the struct...

    Authors: Haseena P. A., Nimisha Basavaraju, Mahesh Chandran, Abdul Jaleel, David A. Bennett and Reddy Peera Kommaddi
    Citation: Alzheimer's Research & Therapy 2024 16:200
  16. There is initial evidence suggesting that biomarker neurogranin (Ng) may distinguish Alzheimer’s disease (AD) from other neurodegenerative diseases. Therefore, we assessed (a) the discriminant ability of cereb...

    Authors: Vanesa Jurasova, Ross Andel, Alzbeta Katonova, Katerina Veverova, Terezie Zuntychova, Hana Horakova, Martin Vyhnalek, Tereza Kolarova, Vaclav Matoska, Kaj Blennow and Jakub Hort
    Citation: Alzheimer's Research & Therapy 2024 16:199
  17. The Clinical Dementia Rating (CDR) scale allows to detect the presence of dementia and to assess its severity, however its evaluation requires a significant time (45 min). We evaluated the agreement between tw...

    Authors: Virginie Dauphinot, Sylvain Calvi, Claire Moutet, Jing Xie, Sophie Dautricourt, Anthony Batsavanis, Pierre Krolak-Salmon and Antoine Garnier-Crussard
    Citation: Alzheimer's Research & Therapy 2024 16:198
  18. Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflect...

    Authors: Katsuya Sakimura, Takashi Kawai, Reiko Nashida, Yuji Ishida, Kana Harada, Takashi Suzuki, Chihiro Okuma and Gregory M. Cole
    Citation: Alzheimer's Research & Therapy 2024 16:197
  19. While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms (NPS) and lifelong mental activities in these patients are scarce. Since NPS are associ...

    Authors: Marc Dörner, Anthony Tyndall, Nicolin Hainc, Roland von Känel, Katja Neumann, Sebastian Euler, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Anna-Charlotte John, Annkatrin Hildebrand…
    Citation: Alzheimer's Research & Therapy 2024 16:196
  20. Authors: Elsa Reallon, Frédéric Gervais, Claire Moutet, Virginie Dauphinot, Pauline Desnavailles, Teddy Novais, Pierre Krolak‑Salmon, Antoine Garnier‑Crussard and Christelle Mouchoux
    Citation: Alzheimer's Research & Therapy 2024 16:195

    The original article was published in Alzheimer's Research & Therapy 2024 16:163

  21. Increasing evidence supports the association between body mass index (BMI), Alzheimer’s disease, and vascular markers. Recently, metabolically unhealthy conditions have been reported to affect the expression o...

    Authors: Eun Hye Lee, Heejin Yoo, Young Ju Kim, Bo Kyoung Cheon, Seungho Ryu, Yoosoo Chang, Jihwan Yun, Hyemin Jang, Jun Pyo Kim, Hee Jin Kim, Seong-Beom Koh, Jee Hyang Jeong, Duk L. Na, Sang Won Seo and Sung Hoon Kang
    Citation: Alzheimer's Research & Therapy 2024 16:194
  22. Traumatic brain injury (TBI) and repetitive head impacts (RHI) have been linked to increased risk for multiple types of neurodegenerative disease, higher dementia risk, and earlier age of dementia symptom onse...

    Authors: Breton M. Asken, Jessica M. Bove, Russell M. Bauer, Jeremy A. Tanner, Kaitlin B. Casaletto, Adam M. Staffaroni, Lawren VandeVrede, Michael L. Alosco, Jesse B. Mez, Robert A. Stern, Bruce L. Miller, Lea T. Grinberg, Adam L. Boxer, Maria Luisa Gorno-Tempini, Howie J. Rosen, Gil D. Rabinovici…
    Citation: Alzheimer's Research & Therapy 2024 16:193
  23. Protein biomarkers have been broadly investigated in cerebrospinal fluid and blood for the detection of neurodegenerative diseases, yet a clinically useful diagnostic test to detect early, pre-symptomatic Alzh...

    Authors: Konstantina Sampani, Steven Ness, Fatima Tuz-Zahra, Nurgul Aytan, Elizabeth E. Spurlock, Sreevardhan Alluri, Xuejing Chen, Nicole H. Siegel, Michael L. Alosco, Weiming Xia, Yorghos Tripodis, Thor D. Stein and Manju L. Subramanian
    Citation: Alzheimer's Research & Therapy 2024 16:192
  24. Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored...

    Authors: Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen…
    Citation: Alzheimer's Research & Therapy 2024 16:190
  25. Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence. There have been major breakthroughs in clinical cancer research leading to some effec...

    Authors: Gregory A. Jicha, Thomas C. Tucker, Susanne M. Arnold and Peter T. Nelson
    Citation: Alzheimer's Research & Therapy 2024 16:184
  26. As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer’s disease (AD) has long been a research hotspot. Amyloid deposition has been shown to be a major pathological f...

    Authors: An-Yi Wang, He-Ying Hu, Liang-Yu Huang, Chu-Yun Xiao, Qiong-Yao Li, Lan Tan and Hao Hu
    Citation: Alzheimer's Research & Therapy 2024 16:189
  27. Polygenic risk scores (PRS) and subjective cognitive decline (SCD) are associated with the risk of developing dementia. It remains to examine whether they can improve the established cardiovascular risk factor...

    Authors: Kira Trares, Hannah Stocker, Joshua Stevenson-Hoare, Laura Perna, Bernd Holleczek, Konrad Beyreuther, Ben Schöttker and Hermann Brenner
    Citation: Alzheimer's Research & Therapy 2024 16:188
  28. Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Individuals with PCA have relatively early-onset and progressive dementia, posing certain ne...

    Authors: Yuzhu Gao, Ruihan Wang, Kefan Mou, Yifan Zhang, Hanyue Xu, Yilin Liu, Feng Yang, Yunxia Gao, Xiaoyue Wang, Li Bao, Jie Zhang, Qin Chen, Hongbo Yin and Ming Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:187
  29. Plasma p-tau217 has emerged as the most promising blood-based marker (BBM) for the detection of Alzheimer Disease (AD) pathology, yet few studies have evaluated plasma p-tau217 performance in memory clinic set...

    Authors: Adam H. Dyer, Helena Dolphin, Antoinette O’Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis…
    Citation: Alzheimer's Research & Therapy 2024 16:186
  30. The cholinergic neurotransmitter system is crucial to cognitive function, with the basal forebrain (BF) being particularly susceptible to Alzheimer’s disease (AD) pathology. However, the interaction of white m...

    Authors: Ye Eun Kim, Jae-Sung Lim, Chong Hyun Suh, Hwon Heo, Jee Hoon Roh, E-nae Cheong, Yoojin Lee, Jae Woo Kim and Jae-Hong Lee
    Citation: Alzheimer's Research & Therapy 2024 16:185
  31. Alzheimer's disease (AD) is the most prevalent dementia, showing higher incidence in women. Besides, lipids play an essential role in brain, and they could be dysregulated in neurodegeneration. Specifically, i...

    Authors: Laura Ferré-González, Ángel Balaguer, Marta Roca, Artemis Ftara, Ana Lloret and Consuelo Cháfer-Pericás
    Citation: Alzheimer's Research & Therapy 2024 16:183
  32. Herpes zoster (HZ), commonly known as “shingles,” may contribute to cognitive decline through mechanisms such as neuroinflammation or direct neuronal injury. However, evidence on the longitudinal association b...

    Authors: Tian-Shin Yeh, Gary C. Curhan, Barbara P. Yawn, Walter C. Willett and Sharon G. Curhan
    Citation: Alzheimer's Research & Therapy 2024 16:180
  33. Precisely defining the delay in onset of dementia is a particular challenge for early diagnosis. Brain [18F] fluoro-2-deoxy-2-D-glucose (18F-FDG) Positron Emission Tomography (PET) is a particularly interesting t...

    Authors: Sébastien Heyer, Maïa Simon, Matthieu Doyen, Ali Mortada, Véronique Roch, Elodie Jeanbert, Nathalie Thilly, Catherine Malaplate, Anna Kearney-Schwartz, Thérèse Jonveaux, Aurélie Bannay and Antoine Verger
    Citation: Alzheimer's Research & Therapy 2024 16:182
  34. This study investigated the correlation between protein intake and Alzheimer’s disease (AD)-related cognitive decline, particularly in episodic memory, among older adults without dementia. Furthermore, we asse...

    Authors: Musung Keum, Boung Chul Lee, Young Min Choe, Guk-Hee Suh, Shin Gyeom Kim, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi and Jee Wook Kim
    Citation: Alzheimer's Research & Therapy 2024 16:181
  35. Microglial activation has been suggested to be involved in the pathogenesis of depression and Alzheimer’s disease (AD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a marker of microgli...

    Authors: Xue Liu, Guang-Xiang Yu, Mei Xue, Liang-Yu Huang, Yan Fu, Zuo-Teng Wang, Lan Tan and Ya-Nan Ou
    Citation: Alzheimer's Research & Therapy 2024 16:179
  36. Authors: Charlotte Havreng-Théry, Bruno Oquendo, Victoria Zolnowski-Kolp, Pierre Krolak-Salmon, François Bertin-Hugault, Carmelo Lafuente-Lafuente and Joël Belmin
    Citation: Alzheimer's Research & Therapy 2024 16:178

    The original article was published in Alzheimer's Research & Therapy 2024 16:117

  37. Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid...

    Authors: Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison…
    Citation: Alzheimer's Research & Therapy 2024 16:176
  38. Several (inter)national longitudinal dementia observational datasets encompassing demographic information, neuroimaging, biomarkers, neuropsychological evaluations, and muti-omics data, have ushered in a new e...

    Authors: Yihan Wang, Shu Liu, Alanna G. Spiteri, Andrew Liem Hieu Huynh, Chenyin Chu, Colin L. Masters, Benjamin Goudey, Yijun Pan and Liang Jin
    Citation: Alzheimer's Research & Therapy 2024 16:175
  39. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and social behaviors, leading to a significant decline in an individual’s quality of life. Auditor...

    Authors: Leelavathi Thamizhmani, Kanaka Ganapathy, Hari Prakash Palaniswamy, Divya Sussana Patil and Suzanne Carolyn Purdy
    Citation: Alzheimer's Research & Therapy 2024 16:174
  40. Targeting brain insulin resistance (BIR) has become an attractive alternative to traditional therapeutic treatments for Alzheimer’s disease (AD). Incretin receptor agonists (IRAs), targeting either or both of ...

    Authors: Noor Abdulhameed, Alice Babin, Kim Hansen, Riley Weaver, William A. Banks, Konrad Talbot and Elizabeth M. Rhea
    Citation: Alzheimer's Research & Therapy 2024 16:173
  41. Blood-brain barrier (BBB) alterations may contribute to AD pathology through various mechanisms, including impaired amyloid-β (Aβ) clearance and neuroinflammation. Soluble platelet-derived growth factor recept...

    Authors: Lukas Preis, Kersten Villringer, Frederic Brosseron, Emrah Düzel, Frank Jessen, Gabor C. Petzold, Alfredo Ramirez, Annika Spottke, Jochen B. Fiebach and Oliver Peters
    Citation: Alzheimer's Research & Therapy 2024 16:172
  42. Isoprostanes and prostaglandins are biomarkers for oxidative stress and inflammation. Their role in Alzheimer's disease (AD) pathophysiology is yet unknown. In the current study, we aim to identify the associa...

    Authors: Shahzad Ahmad, Wei Yang, Adelina Orellana, Lutz Frölich, Itziar de Rojas, Amanda Cano, Mercè Boada, Isabel Hernández, Lucrezia Hausner, Amy C. Harms, Margot H. M. Bakker, Alfredo Cabrera-Socorro, Najaf Amin, Alfredo Ramírez, Agustín Ruiz, Cornelia M. Van Duijn…
    Citation: Alzheimer's Research & Therapy 2024 16:171
  43. Dementia with Lewy Bodies (DLB) is responsible for cognitive-behavioural disorders but also for gait disorders. The latter are thought to be related to parkinsonism, but the neural bases of these disorders are...

    Authors: Adele Sainsily-Cesarus, Elise Schmitt, Lionel Landre, Anne Botzung, Lucie Rauch, Catherine Demuynck, Nathalie Philippi, Paulo Loureiro de Sousa, Catherine Mutter, Benjamin Cretin, Catherine Martin-Hunyadi and Frederic Blanc
    Citation: Alzheimer's Research & Therapy 2024 16:170
  44. Cerebral amyloid angiopathy (CAA) is characterized by amyloid-β (Aβ) deposition in cerebral vessels, leading to lobar cerebral microbleeds (CMB) and intracerebral hemorrhages (ICH). Apolipoprotein J (ApoJ) is ...

    Authors: Anna Bonaterra-Pastra, Montse Solé, Silvia Lope-Piedrafita, Maria Lucas-Parra, Laura Castellote, Paula Marazuela, Olalla Pancorbo, David Rodríguez-Luna and Mar Hernández-Guillamon
    Citation: Alzheimer's Research & Therapy 2024 16:169
  45. Authors: Javier Arranz, Nuole Zhu, Sara Rubio-Guerra, Íñigo Rodríguez-Baz, Rosa Ferrer, María Carmona-Iragui, Isabel Barroeta, Ignacio Illán-Gala, Miguel Santos-Santos, Juan Fortea, Alberto Lleó, Mireia Tondo and Daniel Alcolea
    Citation: Alzheimer's Research & Therapy 2024 16:168

    The original article was published in Alzheimer's Research & Therapy 2024 16:139

  46. Sex differences in neuroinflammation could contribute to women’s increased risk of Alzheimer’s disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine...

    Authors: Anne-Brita Knapskog, Trine Holt Edwin, Per Magne Ueland, Arve Ulvik, Evandro Fei Fang, Rannveig Sakshaug Eldholm, Nathalie Bodd Halaas, Lasse M. Giil, Ingvild Saltvedt, Leiv Otto Watne and Mari Aksnes
    Citation: Alzheimer's Research & Therapy 2024 16:167
  47. The identification of factors involved in the conversion across the different Alzheimer’s disease (AD) stages is crucial to prevent or slow the disease progression. We aimed to assess the factors and their com...

    Authors: Virginie Dauphinot, Marie Laurent, Martin Prodel, Alexandre Civet, Alexandre Vainchtock, Claire Moutet, Pierre Krolak-Salmon and Antoine Garnier-Crussard
    Citation: Alzheimer's Research & Therapy 2024 16:166
  48. Neuropsychiatric symptoms (NPS) are common in older people, may occur early in the development of dementia disorders, and have been associated with faster cognitive decline. Here, our objectives were to invest...

    Authors: Miriam Rabl, Leonardo Zullo, Piotr Lewczuk, Johannes Kornhuber, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Francesco Bavato, Boris B. Quednow, Erich Seifritz, Armin von Gunten, Christopher Clark and Julius Popp
    Citation: Alzheimer's Research & Therapy 2024 16:165