Alzheimer's Research & Therapy

Resilience in Dementia Series

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Brain resilience is the process of adapting well in the face of significant sources of stress, such as Alzheimer’s disease pathology, other neurodegenerative conditions or biological aging. This thematic series provides a comprehensive overview of what factors contribute to brain resilience and how this affects brain health and cognitive function.

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Guest Editor: Rik Ossenkoppele

Publication: Ongoing but closed for submissions

Content type: Research
| 21 March 2019

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Authors: Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan and Qing-Rong Liu
Content type: Research
| 21 March 2019

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Authors: Gemma Salvadó, José Luis Molinuevo, Anna Brugulat-Serrat, Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Javier Pavia, Aida Niñerola-Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow and Juan Domingo Gispert
Content type: Research
| 21 March 2019

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

Authors: Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye and André Strydom
Content type: Research
| 20 March 2019

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Authors: Marie Bruun, Kristian S. Frederiksen, Hanneke F. M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Daniel Rueckert, Nadia Dyremose, Birgitte B. Andersen, Afina W. Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka…
Content type: Meeting report
| 13 March 2019

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings

Authors: Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly…

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Content type: Research
| 15 March 2011

Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice

Authors: Bin Li, Maria E Gonzalez-Toledo, Chun-Shu Piao, Allen Gu, Roger E Kelley and Li-Ru Zhao
Content type: Review
| 24 December 2014

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Authors: Robert Vassar
Content type: Research
| 3 July 2014

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

Authors: Jeffrey L Cummings, Travis Morstorf and Kate Zhong
Content type: Research
| 1 August 2014

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Authors: Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak and Michal Novak
Content type: Review
| 11 June 2014

Cerebral microbleeds: overview and implications in cognitive impairment

Authors: Sergi Martinez-Ramirez, Steven M Greenberg and Anand Viswanathan

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Aims and scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports.

Although the primary focus is Alzheimer's disease, the scope encompasses translational research into other neurodegenerative diseases.

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21 September 2018

Alzheimer's Research & Therapy

Resilience in Dementia Series

Articles

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings

Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Cerebral microbleeds: overview and implications in cognitive impairment

Aims and scope

Latest Tweets

Alzheimer's blogs from BMC

Spotlight on Alzheimer’s Research: Brain Awareness Week 2019

Exergaming to improve complex motor-cognitive performances in patients suffering from dementia

World Alzheimer’s Day: Every 3 seconds someone in the world develops dementia

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