Alzheimer's Research & Therapy

Resilience in Dementia Series

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Brain resilience is the process of adapting well in the face of significant sources of stress, such as Alzheimer’s disease pathology, other neurodegenerative conditions or biological aging. This thematic series provides a comprehensive overview of what factors contribute to brain resilience and how this affects brain health and cognitive function.

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Guest Editor: Rik Ossenkoppele

Publication: Ongoing but closed for submissions

Content type: Research
| 24 May 2019

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study

Authors: Willem S. Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L. van Bruchem, Jeannette A. Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer, Jan J. M. Driesen, Lilian J. H. M. Vroegindeweij, Elsbeth C. Thomeer, Susanne E. Hoogers, Anke A. Dijkstra, Sytse U. Zuidema…
Content type: Research
| 17 May 2019

The association of vascular disorders with incident dementia in different age groups

Authors: Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier and Pieter Jelle Visser
Content type: Research
| 15 May 2019

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Authors: Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez and Alfredo J. Miñano-Molina
Content type: Research
| 15 May 2019

Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort

Authors: Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, André Aleman, Craig W. Ritchie, Philip Scheltens and Sietske A. M. Sikkes
Content type: Research
| 13 May 2019

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Authors: Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens and Cheryl L. Wellington

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Content type: Research
| 15 March 2011

Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice

Authors: Bin Li, Maria E Gonzalez-Toledo, Chun-Shu Piao, Allen Gu, Roger E Kelley and Li-Ru Zhao
Content type: Review
| 24 December 2014

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Authors: Robert Vassar
Content type: Research
| 3 July 2014

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

Authors: Jeffrey L Cummings, Travis Morstorf and Kate Zhong
Content type: Research
| 1 August 2014

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Authors: Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak and Michal Novak
Content type: Review
| 11 June 2014

Cerebral microbleeds: overview and implications in cognitive impairment

Authors: Sergi Martinez-Ramirez, Steven M Greenberg and Anand Viswanathan

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Aims and scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports.

Although the primary focus is Alzheimer's disease, the scope encompasses translational research into other neurodegenerative diseases.

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21 September 2018

Alzheimer's Research & Therapy

Resilience in Dementia Series

Articles

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study

The association of vascular disorders with incident dementia in different age groups

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Cerebral microbleeds: overview and implications in cognitive impairment

Aims and scope

Latest Tweets

Alzheimer's blogs from BMC

Spotlight on Alzheimer’s Research: Brain Awareness Week 2019

Exergaming to improve complex motor-cognitive performances in patients suffering from dementia

World Alzheimer’s Day: Every 3 seconds someone in the world develops dementia

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