Research
Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy
Published on: 20 September 2017
Aims and scope
Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports.
Although the primary focus is Alzheimer's disease, the scope encompasses translational research into other neurodegenerative diseases.
Featured research article: Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study
While antidepressant use has been linked to falling, the association between antidepressant use and head injury. In a nationwide matched cohort study in Finland, Taipale et al address this lack, and find a significant association between antidepressant use and head and brain injury in persons with Alzheimer's disease. They call for additional studies to verify this, and urge caution in the use of antidepressants for those with Alzheimer's.
Featured review: Stem cell models of Alzheimer’s disease: progress and challenges
In this review, Arber et al. review recent developments into induced pluripotent stem cell technology, which promises to be physiologically relevant in vitro. They discuss the widespread adoption of this technology, and how these models have contributed to a deeper understanding of the molecular mechanisms of Alzheimer's disease. They conclude by proposing new directions for using this technology in research to take advantage of the potential it holds.
Articles
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Research
Personalized predictive modeling for patients with Alzheimer’s disease using an extension of Sullivan’s life table model
Published on: 20 September 2017
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Research
Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function
Published on: 20 September 2017
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Review
Alzheimer’s disease prevention: from risk factors to early intervention
Published on: 12 September 2017
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Research
Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment
Published on: 12 September 2017
Alzheimer's Disease International news
The World Health Organization (WHO) has unanimously adopted a global plan on dementia at the 70th session of the World Health Assembly in Geneva. The plan follows ten years of advocacy by ADI for a global response to the growing impact of dementia worldwide.
To read more about this global plan, please visit the ADI website here.
Editors-in-Chief
Alzheimer's Research & Therapy is edited by Philip Scheltens, Todd Golde and Doug Galasko. Find the full Editorial Board here.
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