Xu J, Kochanek KD, Murphy SL, Tejada-Vera B, Division of Vital Statistics: Deaths: final data for 2007. National Vital Statistics Reports. 2010, 58: 19-
Google Scholar
Yankner BA, Lu T: Amyloid β-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009, 284: 4755-4759. 10.1074/jbc.R800018200.
Article
PubMed Central
CAS
PubMed
Google Scholar
McGeer PL, McGeer EG: Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging. 2001, 22: 799-809. 10.1016/S0197-4580(01)00289-5.
Article
CAS
PubMed
Google Scholar
Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S: Powerful beneficial effects of macrophage colony-stimulating factor on β-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain. 2009, 132: 1078-1092. 10.1093/brain/awn331.
Article
PubMed
Google Scholar
Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, Suzumura A: Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid β neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol. 2009, 175: 2121-2132. 10.2353/ajpath.2009.090418.
Article
PubMed Central
CAS
PubMed
Google Scholar
Simard AR, Soulet D, Gowing G, Julien JP, Rivest S: Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron. 2006, 49: 489-502. 10.1016/j.neuron.2006.01.022.
Article
CAS
PubMed
Google Scholar
Galli SJ, Zsebo KM, Geissler EN: The kit ligand, stem cell factor. Adv Immunol. 1994, 55: 1-96. full_text.
Article
CAS
PubMed
Google Scholar
Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G: Filgrastim (r-metHuG-CSF): the first 10 years. Blood. 1996, 88: 1907-1929.
CAS
PubMed
Google Scholar
Zhao LR, Singhal S, Duan WM, Mehta J, Kessler JA: Brain repair by hematopoietic growth factors in a rat model of stroke. Stroke. 2007, 38: 2584-2591. 10.1161/STROKEAHA.106.476457.
Article
PubMed
Google Scholar
Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab S: Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke. 2003, 34: 745-751. 10.1161/01.STR.0000057814.70180.17.
Article
PubMed
Google Scholar
Shyu WC, Lin SZ, Yang HI, Tzeng YS, Pang CY, Yen PS, Li H: Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation. 2004, 110: 1847-1854. 10.1161/01.CIR.0000142616.07367.66.
Article
CAS
PubMed
Google Scholar
Zhao LR, Berra HH, Duan WM, Singhal S, Mehta J, Apkarian AV, Kessler JA: Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats. Stroke. 2007, 38: 2804-2811. 10.1161/STROKEAHA.107.486217.
Article
CAS
PubMed
Google Scholar
Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW: Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience. 2009, 163: 55-72. 10.1016/j.neuroscience.2009.05.071.
Article
CAS
PubMed
Google Scholar
Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR: Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001, 17: 157-165. 10.1016/S1389-0344(01)00067-3.
Article
CAS
PubMed
Google Scholar
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR: Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004, 13: 159-170. 10.1093/hmg/ddh019.
Article
CAS
PubMed
Google Scholar
ImageJ Software. [http://imagej.nih.gov/ij/download.html]
Imai Y, Kohsaka S: Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia. 2002, 40: 164-174. 10.1002/glia.10149.
Article
PubMed
Google Scholar
Edling CE, Hallberg B: c-Kit - a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol. 2007, 39: 1995-1998. 10.1016/j.biocel.2006.12.005.
Article
CAS
PubMed
Google Scholar
Guth S, Miltenyi S, Schmitz J: Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood [abstract]. Immunol Today. 1995, 16 Suppl: s305-s362.
Google Scholar
de Revel T, Appelbaum FR, Storb R, Schuening F, Nash R, Deeg J, McNiece I, Andrews R, Graham T: Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs. Blood. 1994, 83: 3795-3799.
CAS
PubMed
Google Scholar
Hess DA, Levac KD, Karanu FN, Rosu-Myles M, White MJ, Gallacher L, Murdoch B, Keeney M, Ottowski P, Foley R, Chin-Yee I, Bhatia M: Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell factor. Blood. 2002, 100: 869-878. 10.1182/blood.V100.3.869.
Article
CAS
PubMed
Google Scholar
Piao CS, Gonzalez-Toledo ME, Xue YQ, Duan WM, Terao S, Granger DN, Kelley RE, Zhao LR: The role of stem cell factor and granulocyte-colony stimulating factor in brain repair during chronic stroke. J Cereb Blood Flow Metab. 2009, 29: 759-770. 10.1038/jcbfm.2008.168.
Article
CAS
PubMed
Google Scholar
Simard AR, Rivest S: Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J. 2004, 18: 998-1000.
CAS
PubMed
Google Scholar
Corti S, Locatelli F, Strazzer S, Salani S, Del Bo R, Soligo D, Bossolasco P, Bresolin N, Scarlato G, Comi GP: Modulated generation of neuronal cells from bone marrow by expansion and mobilization of circulating stem cells with in vivo cytokine treatment. Exp Neurol. 2002, 177: 443-452. 10.1006/exnr.2002.8004.
Article
CAS
PubMed
Google Scholar
Chan WY, Kohsaka S, Rezaie P: The origin and cell lineage of microglia: new concepts. Brain Res Rev. 2007, 53: 344-354. 10.1016/j.brainresrev.2006.11.002.
Article
CAS
PubMed
Google Scholar
Cameron B, Landreth GE: Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis. 2010, 37: 503-509. 10.1016/j.nbd.2009.10.006.
Article
PubMed Central
CAS
PubMed
Google Scholar
Combs CK: Inflammation and microglia actions in Alzheimer's disease. J Neuroimmune Pharmacol. 2009, 4: 380-388. 10.1007/s11481-009-9165-3.
Article
PubMed
Google Scholar
Leung E, Guo L, Bu J, Maloof M, Khoury JE, Geula C: Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex. Neurobiol Aging. 2009, 32: 387-397. 10.1016/j.neurobiolaging.2009.02.025.
Article
PubMed Central
PubMed
Google Scholar
Laske C, Stellos K, Stransky E, Seizer P, Akcay O, Eschweiler GW, Leyhe T, Gawaz M: Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease. J Alzheimers Dis. 2008, 15: 451-460.
CAS
PubMed
Google Scholar
Laske C, Stellos K, Stransky E, Leyhe T, Gawaz M: Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease. J Alzheimers Dis. 2009, 17: 115-123.
CAS
PubMed
Google Scholar