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  1. Our study aims to evaluate the genetic and phenotypic spectrum of Frontotemporal dementia (FTD) gene variant carriers in Chinese populations, investigate mutation frequencies, and assess the functional propert...

    Authors: Haitian Nan, Yeon-Jeong Kim, Min Chu, Dan Li, Jieying Li, Deming Jiang, Yiming Wu, Toshihisa Ohtsuka and Liyong Wu
    Citation: Alzheimer's Research & Therapy 2024 16:127
  2. Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded in the World-Wide FINGERS initiative, FINGER-NL aims to inv...

    Authors: Kay Deckers, Marissa D. Zwan, Lion M. Soons, Lisa Waterink, Sonja Beers, Sofie van Houdt, Berrit Stiensma, Judy Z. Kwant, Sophie C. P. M. Wimmers, Rachel A. M. Heutz, Jurgen A. H. R. Claassen, Joukje M. Oosterman, Rianne A. A. de Heus, Ondine van de Rest, Yannick Vermeiren, Richard C. Oude Voshaar…
    Citation: Alzheimer's Research & Therapy 2024 16:126
  3. Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer’s disease. There has been increasing awareness of the relationship between long-term blood pr...

    Authors: Sungjoo Lee, Si Eun Kim, Hyemin Jang, Jun Pyo Kim, Gyeongmo Sohn, Yu Hyun Park, Hongki Ham, Yuna Gu, Chae Jung Park, Hee Jin Kim, Duk L. Na, Kyunga Kim and Sang Won Seo
    Citation: Alzheimer's Research & Therapy 2024 16:125
  4. Higher order regulation of autonomic function is maintained by the coordinated activity of specific cortical and subcortical brain regions, collectively referred to as the central autonomic network (CAN). Auto...

    Authors: Trevor Lohman, Arunima Kapoor, Allison C. Engstrom, Fatemah Shenasa, John Paul M. Alitin, Aimee Gaubert, Kathleen E. Rodgers, David Bradford, Mara Mather, S. Duke Han, Elizabeth Head, Lorena Sordo, Julian F. Thayer and Daniel A. Nation
    Citation: Alzheimer's Research & Therapy 2024 16:124
  5. Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the development of associated pathologies after surgeries with contaminated i...

    Authors: Joshua Raine, Nicholas Tolwinski, Jan Gruber and Ajay S. Mathuru
    Citation: Alzheimer's Research & Therapy 2024 16:123
  6. Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of ...

    Authors: Dean Ornish, Catherine Madison, Miia Kivipelto, Colleen Kemp, Charles E. McCulloch, Douglas Galasko, Jon Artz, Dorene Rentz, Jue Lin, Kim Norman, Anne Ornish, Sarah Tranter, Nancy DeLamarter, Noel Wingers, Carra Richling, Rima Kaddurah-Daouk…
    Citation: Alzheimer's Research & Therapy 2024 16:122
  7. Beta-amyloid (Aβ) deposition in the brain parenchyma is a crucial initiating step in the amyloid cascade hypothesis of Alzheimer’s disease (AD) pathology. Furthermore, dysfunction of plaque-associated microgli...

    Authors: Xueting Wang, Yuqi Xie, Xiaoyang Fan, Xiaomei Wu, Dan Wang and Li Zhu
    Citation: Alzheimer's Research & Therapy 2024 16:121
  8. Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes referenc...

    Authors: Shuyi Guo and Jingjing Yang
    Citation: Alzheimer's Research & Therapy 2024 16:120
  9. Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontop...

    Authors: Jennifer Pahl, Prokopis C. Prokopiou, Elisenda Bueichekú, Aaron P. Schultz, Kathryn V. Papp, Michelle E. Farrell, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson and Heidi I.L. Jacobs
    Citation: Alzheimer's Research & Therapy 2024 16:119
  10. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet tria...

    Authors: Charlotta Thunborg, Rui Wang, Anna Rosenberg, Shireen Sindi, Pia Andersen, Sandrine Andrieu, Laus M. Broersen, Nicola Coley, Celine Couderc, Celine Z. Duval, Gerd Faxen-Irving, Göran Hagman, Merja Hallikainen, Krister Håkansson, Eija Kekkonen, Jenni Lehtisalo…
    Citation: Alzheimer's Research & Therapy 2024 16:118
  11. A large proportion of nursing home (NH) residents suffer from dementia and effects of conventional anti-dementia drugs on their health is poorly known. We aimed to investigate the associations between exposure...

    Authors: Charlotte Havreng-Théry, Bruno Oquendo, Victoria Zolnowski-Kolp, Pierre Krolak-Salmon, François Bertin-Hugault, Carmelo Lafuente-Lafuente and Joël Belmin
    Citation: Alzheimer's Research & Therapy 2024 16:117
  12. Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early st...

    Authors: Yoshiki Niimi, Shorena Janelidze, Kenichiro Sato, Naoki Tomita, Tadashi Tsukamoto, Takashi Kato, Kenji Yoshiyama, Hisatomo Kowa, Atsushi Iwata, Ryoko Ihara, Kazushi Suzuki, Kensaku Kasuga, Takeshi Ikeuchi, Kenji Ishii, Kengo Ito, Akinori Nakamura…
    Citation: Alzheimer's Research & Therapy 2024 16:115
  13. Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer’s disease (AD), as supported by epidemiological and preclinical data, and several epidemiological studies...

    Authors: Luca Lorenzini, Lorenzo Zanella, Michele Sannia, Vito Antonio Baldassarro, Marzia Moretti, Maura Cescatti, Corinne Quadalti, Simone Baldi, Gianluca Bartolucci, Leandro Di Gloria, Matteo Ramazzotti, Paolo Clavenzani, Anna Costanzini, Roberto De Giorgio, Amedeo Amedei, Laura Calzà…
    Citation: Alzheimer's Research & Therapy 2024 16:116
  14. Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. Despite decades of research into therapeutic strategies for AD, effective prevention or treatm...

    Authors: Zhihai Huang, Michael R. Hamblin and Quanguang Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:114
  15. The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their ...

    Authors: Amber Yaqub, Dina Vojinovic, Meike W. Vernooij, P. Eline Slagboom, Mohsen Ghanbari, Marian Beekman, Jeroen van der Grond, Thomas Hankemeier, Cornelia M. van Duijn, M. Arfan Ikram and Shahzad Ahmad
    Citation: Alzheimer's Research & Therapy 2024 16:113
  16. Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tau tangles, and neurodegeneration in the brain parenchyma. Here, we aimed to (i) assess differences in ...

    Authors: Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J. Ashton, Thomas K. Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne and Anniina Snellman
    Citation: Alzheimer's Research & Therapy 2024 16:112
  17. Cognitive impairment is common after stroke, and a large proportion of stroke patients will develop dementia. However, there have been few large prospective studies which have assessed cognition both prior to ...

    Authors: Swarna Vishwanath, Ingrid Hopper, Geoffrey C. Cloud, Trevor T-J Chong, Raj C. Shah, Geoffrey A. Donnan, Jeff D. Williamson, Charles B. Eaton, Rory Wolfe, Christopher M. Reid, Andrew M. Tonkin, Suzanne G. Orchard, Sharyn Fitzgerald, Anne M. Murray, Robyn L. Woods, Mark R. Nelson…
    Citation: Alzheimer's Research & Therapy 2024 16:111
  18. Plasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited for secondary prevention programs in self-sufficient persons at-risk of dementia. Plasma bio...

    Authors: Augusto J. Mendes, Federica Ribaldi, Aurelien Lathuiliere, Nicholas J. Ashton, Henrik Zetterberg, Marc Abramowicz, Max Scheffler, Frédéric Assal, Valentina Garibotto, Kaj Blennow and Giovanni B. Frisoni
    Citation: Alzheimer's Research & Therapy 2024 16:110
  19. As one major symptom of Alzheimer’s disease (AD), anterograde amnesia describes patients with an inability in new memory formation. The crucial role of the entorhinal cortex in forming new memories has been we...

    Authors: Nan Zhang, Yixuan Sui, Peter Jendrichovsky, Hemin Feng, Heng Shi, Xu Zhang, Shenghui Xu, Wenjian Sun, Huatang Zhang, Xi Chen, Micky D. Tortorella and Jufang He
    Citation: Alzheimer's Research & Therapy 2024 16:109
  20. Sporadic cerebral amyloid angiopathy (sCAA) is a disease characterised by the progressive deposition of the amyloid beta (Aβ) in the cerebral vasculature, capable of causing a variety of symptoms, from (mild) ...

    Authors: Marc Vervuurt, H. Bea Kuiperij, Anna M. de Kort, Iris Kersten, Catharina J. M. Klijn, Floris H. B. M. Schreuder and Marcel M. Verbeek
    Citation: Alzheimer's Research & Therapy 2024 16:108
  21. The recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the future of diagnosis and management of Alzheimer’s disease (AD) and other neurodegenerat...

    Authors: Daniele Altomare, Ilenia Libri, Antonella Alberici, Jasmine Rivolta, Alessandro Padovani, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow and Barbara Borroni
    Citation: Alzheimer's Research & Therapy 2024 16:107
  22. Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urat...

    Authors: Tingjing Zhang, Yu An, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu and Yang Xia
    Citation: Alzheimer's Research & Therapy 2024 16:106
  23. Alzheimer disease (AD) is a major health problem of aging, with tremendous burden on healthcare systems, patients, and families globally. Lecanemab, an FDA-approved amyloid beta (Aβ)-directed antibody indicate...

    Authors: Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry and Lynn Kramer
    Citation: Alzheimer's Research & Therapy 2024 16:105
  24. Optimal blood pressure (BP) levels to reduce the long-term risk of cognitive decline remains controversial. We aimed to investigate the association between BP and anti-hypertensive treatment status with cognit...

    Authors: Haibin Li, Man Wang, Frank Qian, Zhiyuan Wu, Weida Liu, Anxin Wang and Xiuhua Guo
    Citation: Alzheimer's Research & Therapy 2024 16:104
  25. The role of α-synuclein in dementia has been recognized, yet its exact influence on cognitive decline in non-demented older adults is still not fully understood.

    Authors: Wenying Liu, Wenwen Li, Zhaojun Liu, Yan Li, Xuechu Wang, Mengmeng Guo, Shiyuan Wang, Shuheng Wang, Yan Li and Jianping Jia
    Citation: Alzheimer's Research & Therapy 2024 16:103
  26. Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment...

    Authors: Kitty K. Lui, Abhishek Dave, Kate E. Sprecher, Miranda G. Chappel-Farley, Brady A. Riedner, Margo B. Heston, Chase E. Taylor, Cynthia M. Carlsson, Ozioma C. Okonkwo, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin, Bryce A. Mander and Ruth M. Benca
    Citation: Alzheimer's Research & Therapy 2024 16:102
  27. In Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the pathogenesis of the disease. Identifying approaches to specifically target...

    Authors: Caden M. Henningfield, Neelakshi Soni, Ryan W. Lee, Rishi Sharma, Jeffrey L. Cleland and Kim N. Green
    Citation: Alzheimer's Research & Therapy 2024 16:101
  28. Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...

    Authors: Marco Egle, Jennifer A. Deal, Keenan A. Walker, Dean F. Wong, A. Richey Sharrett and Rebecca F. Gottesman
    Citation: Alzheimer's Research & Therapy 2024 16:100
  29. Patients with sporadic cerebral amyloid angiopathy (sCAA) frequently report cognitive or neuropsychiatric symptoms. The aim of this study is to investigate whether in patients with sCAA, cognitive impairment a...

    Authors: Anna M. De Kort, Kanishk Kaushik, H. Bea Kuiperij, Lieke Jäkel, Hao Li, Anil M. Tuladhar, Gisela M. Terwindt, Marieke J. H. Wermer, Jurgen A. H. R. Claassen, Catharina J. M. Klijn, Marcel M. Verbeek, Roy P. C. Kessels and Floris H. B. M. Schreuder
    Citation: Alzheimer's Research & Therapy 2024 16:99
  30. The identification and staging of Alzheimer’s Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts w...

    Authors: Francesca Conca, Valentina Esposito, Eleonora Catricalà, Rosa Manenti, Federica L’Abbate, Davide Quaranta, Guido Maria Giuffrè, Federica Rossetto, Federica Solca, Beatrice Orso, Emanuela Inguscio, Valeria Crepaldi, Maddalena De Matteis, Emanuela Rotondo, Marina Manera, Giulia Caruso…
    Citation: Alzheimer's Research & Therapy 2024 16:98
  31. The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages of Alzheimer’s disease (AD). Little is known about LC and NBM alteration in limbic-predominant age-related TDP-43 e...

    Authors: Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Camille Noiray, Stéphane Lehericy, Romain Valabrègue, Fabien Caillé, Philippe Gervais, Martin Moussion, Michel Bottlaender and Marie Sarazin
    Citation: Alzheimer's Research & Therapy 2024 16:97
  32. Irregular word reading has been used to estimate premorbid intelligence in Alzheimer’s disease (AD) dementia. However, reading models highlight the core influence of semantic abilities on irregular word readin...

    Authors: Anna Marier, Mahsa Dadar, Florence Bouhali and Maxime Montembeault
    Citation: Alzheimer's Research & Therapy 2024 16:96
  33. Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD). The natural psychedelic N, N-...

    Authors: Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang and Zhang-Jin Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:95
  34. Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future b...

    Authors: Heather E. Dark, Yang An, Michael R. Duggan, Cassandra Joynes, Christos Davatzikos, Guray Erus, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick and Keenan A. Walker
    Citation: Alzheimer's Research & Therapy 2024 16:94
  35. Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biological endpoints. Fluid-based biomarkers may present a solution to measure biologically relevan...

    Authors: Marlies Oosthoek, Lisa Vermunt, Arno de Wilde, Bram Bongers, Daniel Antwi-Berko, Philip Scheltens, Pieter van Bokhoven, Everard G. B. Vijverberg and Charlotte E. Teunissen
    Citation: Alzheimer's Research & Therapy 2024 16:93
  36. Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ 65) exhibit distinct features. Understanding the risk factors for dementia development and mortality in EOD and LOD respecti...

    Authors: Min Young Chun, Wonjeong Chae, Sang Won Seo, Hyemin Jang, Jihwan Yun, Duk L. Na, Dongwoo Kang, Jungkuk Lee, Dustin B. Hammers, Liana G. Apostolova, Sung-In Jang and Hee Jin Kim
    Citation: Alzheimer's Research & Therapy 2024 16:92
  37. Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cognitive function and dementia generates significant concern. This study aimed to investigate...

    Authors: Yujin Park, Su Hwan Kim, Jiwon Ryu and Hyung-Jin Yoon
    Citation: Alzheimer's Research & Therapy 2024 16:91
  38. Plasma neurofilament light chain (NfL) is a promising biomarker of neurodegeneration with potential clinical utility in monitoring the progression of neurodegenerative diseases. However, the cross-sectional as...

    Authors: Rongxiang Tang, Erik Buchholz, Anders M. Dale, Robert A. Rissman, Christine Fennema-Notestine, Nathan A. Gillespie, Donald J Hagler Jr, Michael J. Lyons, Michael C. Neale, Matthew S. Panizzon, Olivia K. Puckett, Chandra A. Reynolds, Carol E. Franz, William S. Kremen and Jeremy A. Elman
    Citation: Alzheimer's Research & Therapy 2024 16:90
  39. Alzheimer’s disease is characterized by large-scale structural changes in a specific pattern. Recent studies developed morphological similarity networks constructed by brain regions similar in structural featu...

    Authors: Ting-Yu Chen, Jun-Ding Zhu, Shih-Jen Tsai and Albert C. Yang
    Citation: Alzheimer's Research & Therapy 2024 16:88
  40. While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR’s stability ...

    Authors: Hao Chen, Jin Hu, Shiqi Gui, Qiushuo Li, Jing Wang, Xing Yang and Jingyuan Yang
    Citation: Alzheimer's Research & Therapy 2024 16:87
  41. Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studie...

    Authors: Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Anna M. de Kort, Thijs W. van Harten, Ellis S. van Etten, Erik W. van Zwet, Erik Stoops, Cindy Francois, Bea H. Kuiperij, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Louise van der Weerd, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Marcel M. Verbeek…
    Citation: Alzheimer's Research & Therapy 2024 16:86
  42. Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damage to the insula has been associated with disorders reflecting impairments of the most f...

    Authors: Alice Tisserand, Frédéric Blanc, Mary Mondino, Candice Muller, Hélène Durand, Catherine Demuynck, Paulo Loureiro de Sousa, Alix Ravier, Léa Sanna, Anne Botzung and Nathalie Philippi
    Citation: Alzheimer's Research & Therapy 2024 16:85
  43. The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge of Alzheimer’s disease (AD). However, the characteristics and prevalence of AD in th...

    Authors: Zhen Liu, Dai Shi, Yue Cai, Anqi Li, Guoyu Lan, Pan Sun, Lin Liu, Yalin Zhu, Jie Yang, Yajing Zhou, Lizhi Guo, Laihong Zhang, Shuqing Deng, Shuda Chen, Xianfeng Yu, Xuhui Chen…
    Citation: Alzheimer's Research & Therapy 2024 16:84
  44. The worldwide trend of demographic aging highlights the progress made in healthcare, albeit with health challenges like Alzheimer’s Disease (AD), prevalent in individuals aged 65 and above. Its early detection...

    Authors: Joel Eyamu, Wuon-Shik Kim, Kahye Kim, Kun Ho Lee and Jaeuk U. Kim
    Citation: Alzheimer's Research & Therapy 2024 16:83
  45. Previous studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which relied on the discovery of early diagnostic biomarkers. In this study,...

    Authors: Xiaoling Wang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Qian Zhang, Yingzhen Zhang, Yujian Fan, Jianping Jia and Peichang Wang
    Citation: Alzheimer's Research & Therapy 2024 16:82
  46. Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the pre...

    Authors: Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi and Gábor Csukly
    Citation: Alzheimer's Research & Therapy 2024 16:81
  47. In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discha...

    Authors: Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B. Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar and Kristian Steen Frederiksen
    Citation: Alzheimer's Research & Therapy 2024 16:80
  48. The hypothesis of decreased neural inhibition in dementia has been sparsely studied in functional magnetic resonance imaging (fMRI) data across patients with different dementia subtypes, and the role of social...

    Authors: Sebastian Moguilner, Rubén Herzog, Yonatan Sanz Perl, Vicente Medel, Josefina Cruzat, Carlos Coronel, Morten Kringelbach, Gustavo Deco, Agustín Ibáñez and Enzo Tagliazucchi
    Citation: Alzheimer's Research & Therapy 2024 16:79
  49. Individuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A + T +), display a rapid cognitive decline and elevated disease progression risk. However, limite...

    Authors: Motonobu Fujishima, Yohei Kawasaki, Toshiharu Mitsuhashi and Hiroshi Matsuda
    Citation: Alzheimer's Research & Therapy 2024 16:77