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  1. Content type: Research

    The typical familial form of Alzheimer’s disease (FAD) accounts for about 5% of total Alzheimer’s disease (AD) cases. Presenilins (PSEN1 and PSEN2) and amyloid-β (A4) precursor protein (APP) genes carry all repor...

    Authors: Lara Paracchini, Luca Beltrame, Lucia Boeri, Federica Fusco, Paolo Caffarra, Sergio Marchini, Diego Albani and Gianluigi Forloni

    Citation: Alzheimer's Research & Therapy 2018 10:106

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  2. Content type: Research

    PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects wi...

    Authors: Philip Scheltens, Merja Hallikainen, Timo Grimmer, Thomas Duning, Alida A Gouw, Charlotte E Teunissen, Alle Meije Wink, Paul Maruff, John Harrison, Caroline M van Baal, Suzanne Bruins, Inge Lues and Niels D Prins

    Citation: Alzheimer's Research & Therapy 2018 10:107

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  3. Content type: Research

    Translational research in Alzheimer’s disease (AD) pathology provides evidence that accumulation of amyloid-β and hyperphosphorylated tau, neuropathological hallmarks of AD, is associated with complex disturba...

    Authors: Milan Stoiljkovic, Craig Kelley, Tamas L. Horvath and Mihály Hajós

    Citation: Alzheimer's Research & Therapy 2018 10:105

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  5. Content type: Research

    With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim of this study wa...

    Authors: Mara ten Kate, Alberto Redolfi, Enrico Peira, Isabelle Bos, Stephanie J. Vos, Rik Vandenberghe, Silvy Gabel, Jolien Schaeverbeke, Philip Scheltens, Olivier Blin, Jill C. Richardson, Regis Bordet, Anders Wallin, Carl Eckerstrom, José Luis Molinuevo, Sebastiaan Engelborghs…

    Citation: Alzheimer's Research & Therapy 2018 10:100

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  6. Content type: Research

    The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear. We examined the correlation of educatio...

    Authors: Na-Yeon Jung, Hanna Cho, Yeo Jin Kim, Hee Jin Kim, Jong Min Lee, Seongbeom Park, Sung Tae Kim, Eun-Joo Kim, Jae Seung Kim, Seung Hwan Moon, Jae-Hong Lee, Michael Ewers, Duk L Na and Sang Won Seo

    Citation: Alzheimer's Research & Therapy 2018 10:103

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  8. Content type: Research

    There are currently no treatments for empathy deficits in neuropsychiatric disorders. Acute administration of the hormone oxytocin has been associated with symptomatic improvements across animal models and sev...

    Authors: Elizabeth Finger, Scott Berry, Jeffrey Cummings, Kristy Coleman, Robin Hsiung, Howard H. Feldman and Adam Boxer

    Citation: Alzheimer's Research & Therapy 2018 10:102

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  9. Content type: Correction

    Following publication of the original article [1], the author reported errors in the formatting of the table. The details of the errors are as follows:

    Authors: Susanne Ostrowitzki, Robert A. Lasser, Ernest Dorflinger, Philip Scheltens, Frederik Barkhof, Tania Nikolcheva, Elizabeth Ashford, Sylvie Retout, Carsten Hofmann, Paul Delmar, Gregory Klein, Mirjana Andjelkovic, Bruno Dubois, Mercè Boada, Kaj Blennow, Luca Santarelli…

    Citation: Alzheimer's Research & Therapy 2018 10:99

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    The original article was published in Alzheimer's Research & Therapy 2017 9:95

  10. Content type: Research

    Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neuropathologic changes involving beta-amyloid (Aβ), tau, neuronal loss, and other associated biological events. While levels o...

    Authors: Umesh Gangishetti, J. Christina Howell, Richard J. Perrin, Natalia Louneva, Kelly D. Watts, Alexander Kollhoff, Murray Grossman, David A. Wolk, Leslie M. Shaw, John C. Morris, John Q. Trojanowski, Anne M. Fagan, Steven E. Arnold and William T. Hu

    Citation: Alzheimer's Research & Therapy 2018 10:98

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  11. Content type: Research

    Age is the cardinal risk factor for Alzheimer’s disease (AD), and white matter hyperintensities (WMH), which are more prevalent with increasing age, may contribute to AD. Higher cardiorespiratory fitness (CRF)...

    Authors: Clayton J. Vesperman, Vincent Pozorski, Ryan J. Dougherty, Lena L. Law, Elizabeth Boots, Jennifer M. Oh, Catherine L. Gallagher, Cynthia M. Carlsson, Howard A. Rowley, Yue Ma, Barbara B. Bendlin, Sanjay Asthana, Mark A. Sager, Bruce P. Hermann, Sterling C. Johnson, Dane B. Cook…

    Citation: Alzheimer's Research & Therapy 2018 10:97

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  12. Content type: Research

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact. Recent epidemiological studies have indicated that the inc...

    Authors: Sylvie L. Lesuis, Lianne Hoeijmakers, Aniko Korosi, Susanne R. de Rooij, Dick F. Swaab, Helmut W. Kessels, Paul J. Lucassen and Harm J. Krugers

    Citation: Alzheimer's Research & Therapy 2018 10:95

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  13. Content type: Research

    We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) immunoglobulin (Ig)G4 monoclonal antibody, on biomarkers of amyloid pathology, neurodegeneration, and disease progression in patient...

    Authors: Stephen Salloway, Lee A. Honigberg, William Cho, Michael Ward, Michel Friesenhahn, Flavia Brunstein, Angelica Quartino, David Clayton, Deborah Mortensen, Tobias Bittner, Carole Ho, Christina Rabe, Stephen P. Schauer, Kristin R. Wildsmith, Reina N. Fuji, Shehnaaz Suliman…

    Citation: Alzheimer's Research & Therapy 2018 10:96

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  14. Content type: Research

    Cholinergic dysfunction is a key abnormality in Alzheimer disease (AD) that can be detected in vivo with transcranial magnetic stimulation (TMS) protocols. Although TMS has clearly demonstrated analytical vali...

    Authors: Alberto Benussi, Antonella Alberici, Clarissa Ferrari, Valentina Cantoni, Valentina Dell’Era, Rosanna Turrone, Maria Sofia Cotelli, Giuliano Binetti, Barbara Paghera, Giacomo Koch, Alessandro Padovani and Barbara Borroni

    Citation: Alzheimer's Research & Therapy 2018 10:94

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  15. Content type: Research

    The principal aim of this study was to demonstrate the gender-specific cognitive patterns among middle-aged and elderly Chinese adults, investigate the risk factors on global and domain-specific cognitive perf...

    Authors: Yu An, Lingli Feng, Xiaona Zhang, Ying Wang, Yushan Wang, Lingwei Tao, Yanhui Lu, Zhongsheng Qin and Rong Xiao

    Citation: Alzheimer's Research & Therapy 2018 10:93

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  16. Content type: Research

    Gender distribution varies across neurodegenerative disorders, with, traditionally, a higher female frequency reported in Alzheimer’s disease (AD) and a higher male frequency in Parkinson’s disease (PD). Confl...

    Authors: A. Mouton, F. Blanc, A. Gros, V. Manera, R. Fabre, E. Sauleau, I. Gomez-Luporsi, K. Tifratene, L. Friedman, S. Thümmler, C. Pradier, P. H. Robert and R. David

    Citation: Alzheimer's Research & Therapy 2018 10:92

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  17. Content type: Review

    Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provid...

    Authors: Anna Catharina van Loenhoud, Colin Groot, Jacob William Vogel, Wiesje Maria van der Flier and Rik Ossenkoppele

    Citation: Alzheimer's Research & Therapy 2018 10:91

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  18. Content type: Research

    Cognitive composite scores are used as the primary outcome measures for Alzheimer’s disease (AD) prevention trials; however, the extent to which these composite measures correlate with AD pathology has not bee...

    Authors: Michael Malek-Ahmadi, Kewei Chen, Sylvia E. Perez, Anna He and Elliott J. Mufson

    Citation: Alzheimer's Research & Therapy 2018 10:90

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  19. Content type: Research

    Interindividual differences in cognitive reserve (CR) are associated with complex and dynamic clinical phenotypes observed in cognitive impairment and dementia. We tested whether (1) CR early in life (E-CR; me...

    Authors: Shraddha Sapkota, Joel Ramirez, Donald T. Stuss, Mario Masellis and Sandra E. Black

    Citation: Alzheimer's Research & Therapy 2018 10:89

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  20. Content type: Research

    Amyloid-beta (Aβ) has a dose-response relationship with cognition in healthy adults. Additionally, the levels of functional connectivity within and between brain networks have been associated with cognitive pe...

    Authors: Roy W. E. Van Hooren, Joost M. Riphagen and Heidi I. L. Jacobs

    Citation: Alzheimer's Research & Therapy 2018 10:88

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  21. Content type: Research

    In this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the res...

    Authors: Piotr Lewczuk, Amélie Gaignaux, Olga Kofanova, Natalia Ermann, Fay Betsou, Sebastian Brandner, Barbara Mroczko, Kaj Blennow, Dominik Strapagiel, Silvia Paciotti, Jonathan Vogelgsang, Michael H. Roehrl, Sandra Mendoza, Johannes Kornhuber and Charlotte Teunissen

    Citation: Alzheimer's Research & Therapy 2018 10:87

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  22. Content type: Research

    A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait loci (rQTL) are often involved in gene-by-gene (G×...

    Authors: Taylor J. Maxwell, Chris Corcoran, Jorge L. del-Aguila, John P. Budde, Yuetiva Deming, Carlos Cruchaga, Alison M. Goate and John S. K. Kauwe

    Citation: Alzheimer's Research & Therapy 2018 10:86

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  23. Content type: Research

    β-Secretase enzyme (BACE) inhibition has been proposed as a priority treatment mechanism for Alzheimer’s disease (AD), but treatment initiation may need to be very early. We present proof of mechanism of atabe...

    Authors: Maarten Timmers, Johannes Rolf Streffer, Alberto Russu, Yushin Tominaga, Hiroko Shimizu, Ayako Shiraishi, Kanaka Tatikola, Pascale Smekens, Anne Börjesson-Hanson, Niels Andreasen, Jorge Matias-Guiu, Miquel Baquero, Mercè Boada, Ina Tesseur, Luc Tritsmans, Luc Van Nueten…

    Citation: Alzheimer's Research & Therapy 2018 10:85

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  24. Content type: Research

    Recently, the field of gene-gene or gene-environment interaction research appears to have gained growing interest, although it is seldom investigated in Alzheimer’s disease (AD). Hence, the current study aims ...

    Authors: Dahyun Yi, Younghwa Lee, Min Soo Byun, Jun Ho Lee, Kang Ko, Bo Kyung Sohn, Young Min Choe, Hyo Jung Choi, Hyewon Baek, Chul-Ho Sohn, Yu Kyeong Kim and Dong Young Lee

    Citation: Alzheimer's Research & Therapy 2018 10:84

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  25. Content type: Research

    Patients with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) show functional and structural connectivity alterations in the default mode network (DMN) while cerebrovascular disease (CeV...

    Authors: Ashwati Vipin, Yng Miin Loke, Siwei Liu, Saima Hilal, Hee Youn Shim, Xin Xu, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen and Juan Zhou

    Citation: Alzheimer's Research & Therapy 2018 10:82

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  26. Content type: Research

    Little is known about the consequences of apathy in dementia with Lewy bodies (DLB), because previous research on apathy in dementia focused mainly on Alzheimer’s disease (AD).

    Authors: Monica H. Breitve, Kolbjørn Brønnick, Luiza J. Chwiszczuk, Minna J. Hynninen, Dag Aarsland and Arvid Rongve

    Citation: Alzheimer's Research & Therapy 2018 10:83

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  27. Content type: Research

    The immune system plays a major role in the pathogenesis of age-related dementia, including Alzheimer’s disease (AD). An insight into age-associated changes in the immune response to amyloid-beta (Aβ) in indiv...

    Authors: Sudhanshu Agrawal, Edsel M. Abud, Shikha Snigdha and Anshu Agrawal

    Citation: Alzheimer's Research & Therapy 2018 10:81

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  28. Content type: Research

    Reliable biomarkers of frontotemporal dementia (FTD) are currently lacking. FTD may be associated with chronic immune dysfunction, microglial activation and raised inflammatory markers, particularly in progran...

    Authors: Ione O. C. Woollacott, Jennifer M. Nicholas, Amanda Heslegrave, Carolin Heller, Martha S. Foiani, Katrina M. Dick, Lucy L. Russell, Ross W. Paterson, Ashvini Keshavan, Nick C. Fox, Jason D. Warren, Jonathan M. Schott, Henrik Zetterberg and Jonathan D. Rohrer

    Citation: Alzheimer's Research & Therapy 2018 10:79

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  29. Content type: Research

    There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) synaptosomal-associated protei...

    Authors: Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A. Pascoal, Pedro Rosa-Neto and Serge Gauthier

    Citation: Alzheimer's Research & Therapy 2018 10:80

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  30. Content type: Review

    The concept of dependence has been proposed as a unified representation of disease severity to quantify and stage disease progression in a manner more informative to patients, caregivers, and healthcare provid...

    Authors: Carolyn W. Zhu, Bote Gosse Bruinsma and Yaakov Stern

    Citation: Alzheimer's Research & Therapy 2018 10:78

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  31. Content type: Research

    Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the...

    Authors: Niklas Mattsson, Rik Ossenkoppele, Ruben Smith, Olof Strandberg, Tomas Ohlsson, Jonas Jögi, Sebastian Palmqvist, Erik Stomrud and Oskar Hansson

    Citation: Alzheimer's Research & Therapy 2018 10:77

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  32. Content type: Research

    We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria.

    Authors: Rosalinde E. R. Slot, Sander C. J. Verfaillie, Jozefien M. Overbeek, Tessa Timmers, Linda M. P. Wesselman, Charlotte E. Teunissen, Annemiek Dols, Femke H. Bouwman, Niels D. Prins, Frederik Barkhof, Adriaan A. Lammertsma, Bart N. M. Van Berckel, Philip Scheltens, Sietske A. M. Sikkes and Wiesje M. Van der Flier

    Citation: Alzheimer's Research & Therapy 2018 10:76

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  33. Content type: Research

    Amyloid pathology is the pathological hallmark in Alzheimer’s disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid pathology leads to cognitive impairment and dement...

    Authors: Elles Konijnenberg, Stephen F. Carter, Mara ten Kate, Anouk den Braber, Jori Tomassen, Chinenye Amadi, Linda Wesselman, Hoang-Ton Nguyen, Jacoba A. van de Kreeke, Maqsood Yaqub, Matteo Demuru, Sandra D. Mulder, Arjan Hillebrand, Femke H. Bouwman, Charlotte E. Teunissen, Erik H. Serné…

    Citation: Alzheimer's Research & Therapy 2018 10:75

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  34. Content type: Research

    Imaging agents capable of quantifying the brain’s tau aggregates will allow a more precise staging of Alzheimer’s disease (AD). The aim of the present study was to examine the in vitro properties as well as th...

    Authors: Tharick A. Pascoal, Monica Shin, Min Su Kang, Mira Chamoun, Daniel Chartrand, Sulantha Mathotaarachchi, Idriss Bennacef, Joseph Therriault, Kok Pin Ng, Robert Hopewell, Reda Bouhachi, Hung-Hsin Hsiao, Andrea L. Benedet, Jean-Paul Soucy, Gassan Massarweh, Serge Gauthier…

    Citation: Alzheimer's Research & Therapy 2018 10:74

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  35. Content type: Correction

    Since the publication of this article [1], it has come to the attention of the authors that information for one of the authors was not included in the competing interests section. Craig Richie has declared pot...

    Authors: Craig W. Ritchie, Tom C. Russ, Sube Banerjee, Bob Barber, Andrew Boaden, Nick C. Fox, Clive Holmes, Jeremy D. Isaacs, Ira Leroi, Simon Lovestone, Matt Norton, John O’Brien, Jim Pearson, Richard Perry, James Pickett, Adam D. Waldman…

    Citation: Alzheimer's Research & Therapy 2018 10:73

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    The original article was published in Alzheimer's Research & Therapy 2017 9:85

  36. Content type: Research

    A growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the screening of neurodegeneration in Alzheimer’s disease (AD).

    Authors: Piotr Lewczuk, Natalia Ermann, Ulf Andreasson, Christian Schultheis, Jana Podhorna, Philipp Spitzer, Juan Manuel Maler, Johannes Kornhuber, Kaj Blennow and Henrik Zetterberg

    Citation: Alzheimer's Research & Therapy 2018 10:71

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  37. Content type: Review

    Disclosure of amyloid positron emission tomography (PET) results to individuals without dementia has become standard practice in secondary prevention trials and also increasingly occurs in clinical practice. H...

    Authors: Arno de Wilde, Marieke M. van Buchem, René H. J. Otten, Femke Bouwman, Andrew Stephens, Frederik Barkhof, Philip Scheltens and Wiesje M. van der Flier

    Citation: Alzheimer's Research & Therapy 2018 10:72

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  38. Content type: Research

    Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP

    Authors: Celeste M. Karch, Damián Hernández, Jen-Chyong Wang, Jacob Marsh, Alex W. Hewitt, Simon Hsu, Joanne Norton, Denise Levitch, Tamara Donahue, Wendy Sigurdson, Bernardino Ghetti, Martin Farlow, Jasmeer Chhatwal, Sarah Berman, Carlos Cruchaga, John C. Morris…

    Citation: Alzheimer's Research & Therapy 2018 10:69

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  39. Content type: Research

    Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plas...

    Authors: Chris J. D. Hardy, Charles R. Marshall, Rebecca L. Bond, Lucy L. Russell, Katrina Dick, Cono Ariti, David L. Thomas, Sonya J. Ross, Jennifer L. Agustus, Sebastian J. Crutch, Jonathan D. Rohrer, Doris-Eva Bamiou and Jason D. Warren

    Citation: Alzheimer's Research & Therapy 2018 10:70

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  40. Content type: Research

    A subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a ‘mixed variant’ phenotype. This phenotype is rare and...

    Authors: Jolien Schaeverbeke, Silvy Gabel, Karen Meersmans, Rose Bruffaerts, Antonietta Gabriella Liuzzi, Charlotte Evenepoel, Eva Dries, Karen Van Bouwel, Anne Sieben, Yolande Pijnenburg, Ronald Peeters, Guy Bormans, Koen Van Laere, Michel Koole, Patrick Dupont and Rik Vandenberghe

    Citation: Alzheimer's Research & Therapy 2018 10:68

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  41. Content type: Research

    A need exists for easily administered assessment tools to detect mild cognitive changes that are more comprehensive than screening tests but shorter than a neuropsychological battery and that can be administer...

    Authors: Morris Freedman, Larry Leach, M. Carmela Tartaglia, Kathryn A. Stokes, Yael Goldberg, Robyn Spring, Nima Nourhaghighi, Tom Gee, Stephen C. Strother, Mohammad O. Alhaj, Michael Borrie, Sultan Darvesh, Alita Fernandez, Corinne E. Fischer, Jennifer Fogarty, Barry D. Greenberg…

    Citation: Alzheimer's Research & Therapy 2018 10:65

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  42. Content type: Research

    Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and ta...

    Authors: Loïc Dayon, Antonio Núñez Galindo, Jérôme Wojcik, Ornella Cominetti, John Corthésy, Aikaterini Oikonomidi, Hugues Henry, Martin Kussmann, Eugenia Migliavacca, India Severin, Gene L. Bowman and Julius Popp

    Citation: Alzheimer's Research & Therapy 2018 10:66

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  43. Content type: Research

    Alzheimer’s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (P...

    Authors: Simon Hsu, Brian A. Gordon, Russ Hornbeck, Joanne B. Norton, Denise Levitch, Adia Louden, Ellen Ziegemeier, Robert Laforce Jr., Jasmeer Chhatwal, Gregory S. Day, Eric McDade, John C. Morris, Anne M. Fagan, Tammie L. S. Benzinger, Alison M. Goate, Carlos Cruchaga…

    Citation: Alzheimer's Research & Therapy 2018 10:67

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  44. Content type: Research

    There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer’s disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the European Medical Informatio...

    Authors: Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Philip Scheltens, Sebastiaan Engelborghs, Giovanni Frisoni, José Luis Molinuevo, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Alison Baird, Richard Dobson, Cristina Legido-Quigley, Kristel Sleegers, Christine Van Broeckhoven…

    Citation: Alzheimer's Research & Therapy 2018 10:64

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  45. Content type: Research

    Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the opportunity for intervention. We studied whether a multi-domai...

    Authors: Tessa van Middelaar, Marieke P. Hoevenaar-Blom, Willem A. van Gool, Eric P. Moll van Charante, Jan-Willem van Dalen, Kay Deckers, Sebastian Köhler and Edo Richard

    Citation: Alzheimer's Research & Therapy 2018 10:62

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  46. Content type: Research

    Plasma amyloid-β (Aβ) levels are increasingly studied as a potential accessible marker of cognitive impairment and dementia. However, it remains underexplored whether plasma Aβ levels including the novel Aβ pe...

    Authors: Saima Hilal, Frank J. Wolters, Marcel M. Verbeek, Hugo Vanderstichele, M. Kamran Ikram, Erik Stoops, M. Arfan Ikram and Meike W. Vernooij

    Citation: Alzheimer's Research & Therapy 2018 10:63

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  48. Content type: Research

    Alzheimer’s disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains ...

    Authors: D. M. Vargas, M. A. De Bastiani, E. R. Zimmer and F. Klamt

    Citation: Alzheimer's Research & Therapy 2018 10:59

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  49. Content type: Research

    Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer’s disease (AD). Vascular endothelial growth factor (VEGF) is one of the key players involved in ...

    Authors: Ananya Chakraborty, Madhurima Chatterjee, Harry Twaalfhoven, Marta Del Campo Milan, Charlotte E. Teunissen, Philip Scheltens, Ruud D. Fontijn, Wiesje M. van Der Flier and Helga E. de Vries

    Citation: Alzheimer's Research & Therapy 2018 10:58

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  50. Content type: Viewpoint

    The performance of [18F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25...

    Authors: Milos D. Ikonomovic, Enrico R. Fantoni, Gill Farrar and Stephen Salloway

    Citation: Alzheimer's Research & Therapy 2018 10:60

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Alzheimer's Research & Therapy

ISSN: 1758-9193