Articles
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Citation: Alzheimer's Research & Therapy 2024 16:168
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Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease
Sex differences in neuroinflammation could contribute to women’s increased risk of Alzheimer’s disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine...
Citation: Alzheimer's Research & Therapy 2024 16:167 -
Identification of profiles associated with conversions between the Alzheimer’s disease stages, using a machine learning approach
The identification of factors involved in the conversion across the different Alzheimer’s disease (AD) stages is crucial to prevent or slow the disease progression. We aimed to assess the factors and their com...
Citation: Alzheimer's Research & Therapy 2024 16:166 -
Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression
Neuropsychiatric symptoms (NPS) are common in older people, may occur early in the development of dementia disorders, and have been associated with faster cognitive decline. Here, our objectives were to invest...
Citation: Alzheimer's Research & Therapy 2024 16:165 -
Moderation of thyroid hormones for the relationship between amyloid and tau pathology
Altered thyroid hormone levels have been associated with increased risk of Alzheimer's disease (AD) dementia and related cognitive decline. However, the neuropathological substrates underlying the link between...
Citation: Alzheimer's Research & Therapy 2024 16:164 -
Impact of cumulative exposure to anticholinergic and sedative drugs on cognition in older adults: a memory clinic cohort study
Long-term exposure to anticholinergic and sedative drugs could be a modifiable risk factor for cognitive decline. The objective of this study was to measure the association between previous cumulative antichol...
Citation: Alzheimer's Research & Therapy 2024 16:163 -
Hormone therapy is associated with lower Alzheimer’s disease tau biomarkers in post-menopausal females -evidence from two independent cohorts
Females represent approximately 70% of the Alzheimer’s disease (AD) cases and the literature has proposed a connection between the decreased estrogen levels during menopause and an increased AD risk. Previous ...
Citation: Alzheimer's Research & Therapy 2024 16:162 -
High cognitive reserve attenuates the risk of dementia associated with cardiometabolic diseases
Cardiometabolic diseases (CMDs) including type 2 diabetes, heart disease, and stroke have been linked to a higher risk of dementia. We examined whether high levels of cognitive reserve (CR) can attenuate the i...
Citation: Alzheimer's Research & Therapy 2024 16:161 -
Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP
Alpha-lipoic acid (ALA) has a neuroprotective effect on neurodegenerative diseases. In the clinic, ALA can improve cognitive impairments in patients with Alzheimer’s disease (AD) and other dementias. Animal st...
Citation: Alzheimer's Research & Therapy 2024 16:160 -
Correction: Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease
Citation: Alzheimer's Research & Therapy 2024 16:159 -
Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
Citation: Alzheimer's Research & Therapy 2024 16:158 -
Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer’s disease pathology in the population?
White matter hyperintensities (WMH) are considered hallmark features of cerebral small vessel disease and have recently been linked to Alzheimer’s disease (AD) pathology. Their distinct spatial distributions, ...
Citation: Alzheimer's Research & Therapy 2024 16:157 -
Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer’s disease
Quantitative transport mapping (QTM) of blood velocity, based on the transport equation has been demonstrated higher accuracy and sensitivity of perfusion quantification than the traditional Kety’s method-base...
Citation: Alzheimer's Research & Therapy 2024 16:156 -
Correction: Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid angiopathy
Citation: Alzheimer's Research & Therapy 2024 16:155 -
Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease
With the approval of disease-modifying treatments (DMTs) for early Alzheimer’s disease (AD), there is an increased need for efficient and non-invasive detection methods for cerebral amyloid-β (Aβ) pathology. C...
Citation: Alzheimer's Research & Therapy 2024 16:154 -
Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder where pathophysiological changes begin decades before the onset of clinical symptoms. Analysis of brain atrophy patterns using structural MR...
Citation: Alzheimer's Research & Therapy 2024 16:153 -
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer’s disease patients: a pilot study
Alzheimer’s Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pi...
Citation: Alzheimer's Research & Therapy 2024 16:152 -
A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease
Amyloid beta protein (Aβ) is a treatment target in Alzheimer’s Disease (AD). Lowering production of its parent protein, APP, has benefits in preclinical models. Posiphen, an orally administered small molecule,...
Citation: Alzheimer's Research & Therapy 2024 16:151 -
Prescription medication use in the 10 years prior to diagnosis of young onset Alzheimer’s disease: a nationwide nested case-control study
Patients with young onset Alzheimer’s disease (YOAD) face long diagnostic delays. Prescription medication use may provide insights into early signs and symptoms, which may help facilitate timely diagnosis.
Citation: Alzheimer's Research & Therapy 2024 16:150 -
Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive performance. However, its clinical diagnostic and predictive value, and ...
Citation: Alzheimer's Research & Therapy 2024 16:149 -
Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
Leveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class mixtur...
Citation: Alzheimer's Research & Therapy 2024 16:148 -
Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
Multimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is known about the effect of lifestyle interventions in patients with pr...
Citation: Alzheimer's Research & Therapy 2024 16:147 -
Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis...
Citation: Alzheimer's Research & Therapy 2024 16:146 -
Heat-related illness and dementia: a study integrating epidemiological and experimental evidence
Heat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We conducted a population-based cohort study and an animal experiment to ...
Citation: Alzheimer's Research & Therapy 2024 16:145 -
APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets
The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β (Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent of amyloid plaques in Alzhe...
Citation: Alzheimer's Research & Therapy 2024 16:144 -
Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer’s disease and related dementias (ADRD). Overlapping...
Citation: Alzheimer's Research & Therapy 2024 16:143 -
The criteria used to rule out mild cognitive impairment impact dementia incidence rates in subjective cognitive decline
The research criteria for subjective cognitive decline (SCD) exclude mild cognitive impairment (MCI), but do not stipulate the use of specific MCI criteria. This study compared different approaches to defining...
Citation: Alzheimer's Research & Therapy 2024 16:142 -
Comparison of plasma soluble and extracellular vesicles-associated biomarkers in Alzheimer’s disease patients and cognitively normal individuals
Amyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD), also present in blood as soluble biomarkers or encapsulated in extracellular vesicles (EVs). Our goal was to assess how soluble plasma bi...
Citation: Alzheimer's Research & Therapy 2024 16:141 -
The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
Non-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cognitive function in patients with Alzheimer’s disease (AD) and mild cognitive impairment...
Citation: Alzheimer's Research & Therapy 2024 16:140 -
Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease
Recently developed blood markers for Alzheimer's disease (AD) detection have high accuracy but usually require ultra-sensitive analytic tools not commonly available in clinical laboratories, and their performa...
Citation: Alzheimer's Research & Therapy 2024 16:139 -
The longitudinal trajectory of CSF sTREM2: the alzheimer’s disease neuroimaging initiative
The soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) is considered a biomarker of microglia activity. The objective of this study was to investigate the trajectory...
Citation: Alzheimer's Research & Therapy 2024 16:138 -
Association between depression and young-onset dementia in middle-aged women
Dementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when diagnosed before the age of 65 years. We aimed to conduct a retrospective co...
Citation: Alzheimer's Research & Therapy 2024 16:137 -
Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study
Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), met...
Citation: Alzheimer's Research & Therapy 2024 16:136 -
Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The a...
Citation: Alzheimer's Research & Therapy 2024 16:135 -
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Aging and sex are major risk factors for developing late-onset Alzheimer’s disease. Compared to men, women experience worse neuropathological burden and cognitive decline despite living longer with the disease...
Citation: Alzheimer's Research & Therapy 2024 16:134 -
Adherence to a lifestyle intervention – just a question of self-efficacy? Analysis of the AgeWell.de-intervention against cognitive decline
Aim of this study was to detect predictors of better adherence to the AgeWell.de-intervention, a two-year randomized multi-domain lifestyle intervention against cognitive decline.
Citation: Alzheimer's Research & Therapy 2024 16:133 -
Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling of large volumes of CSF with indwelling intrathecal catheters used in m...
Citation: Alzheimer's Research & Therapy 2024 16:132 -
Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis
Computer gaming has recently been suggested to be associated with benefits for cognition, but its impact on incident dementia remains uncertain. We aimed to investigate the observational associations of playin...
Citation: Alzheimer's Research & Therapy 2024 16:131 -
Amyloid-PET imaging predicts functional decline in clinically normal individuals
There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associated with cognitive decline in clinically normal (CN) individuals. However, it is less well established wh...
Citation: Alzheimer's Research & Therapy 2024 16:130 -
Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study
Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer’s disease (AD) ha...
Citation: Alzheimer's Research & Therapy 2024 16:129 -
Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study
This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable variable representing the condition of our brain. Among many clinical use cases, brain ag...
Citation: Alzheimer's Research & Therapy 2024 16:128 -
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations
Our study aims to evaluate the genetic and phenotypic spectrum of Frontotemporal dementia (FTD) gene variant carriers in Chinese populations, investigate mutation frequencies, and assess the functional propert...
Citation: Alzheimer's Research & Therapy 2024 16:127 -
A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial
Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded in the World-Wide FINGERS initiative, FINGER-NL aims to inv...
Citation: Alzheimer's Research & Therapy 2024 16:126 -
Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia
Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer’s disease. There has been increasing awareness of the relationship between long-term blood pr...
Citation: Alzheimer's Research & Therapy 2024 16:125 -
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults
Higher order regulation of autonomic function is maintained by the coordinated activity of specific cortical and subcortical brain regions, collectively referred to as the central autonomic network (CAN). Auto...
Citation: Alzheimer's Research & Therapy 2024 16:124 -
Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the development of associated pathologies after surgeries with contaminated i...
Citation: Alzheimer's Research & Therapy 2024 16:123 -
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of ...
Citation: Alzheimer's Research & Therapy 2024 16:122 -
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease
Beta-amyloid (Aβ) deposition in the brain parenchyma is a crucial initiating step in the amyloid cascade hypothesis of Alzheimer’s disease (AD) pathology. Furthermore, dysfunction of plaque-associated microgli...
Citation: Alzheimer's Research & Therapy 2024 16:121 -
Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia
Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes referenc...
Citation: Alzheimer's Research & Therapy 2024 16:120 -
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontop...
Citation: Alzheimer's Research & Therapy 2024 16:119
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- ISSN: 1758-9193 (electronic)