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  1. The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their ...

    Authors: Amber Yaqub, Dina Vojinovic, Meike W. Vernooij, P. Eline Slagboom, Mohsen Ghanbari, Marian Beekman, Jeroen van der Grond, Thomas Hankemeier, Cornelia M. van Duijn, M. Arfan Ikram and Shahzad Ahmad
    Citation: Alzheimer's Research & Therapy 2024 16:113
  2. Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tau tangles, and neurodegeneration in the brain parenchyma. Here, we aimed to (i) assess differences in ...

    Authors: Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J. Ashton, Thomas K. Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne and Anniina Snellman
    Citation: Alzheimer's Research & Therapy 2024 16:112
  3. Cognitive impairment is common after stroke, and a large proportion of stroke patients will develop dementia. However, there have been few large prospective studies which have assessed cognition both prior to ...

    Authors: Swarna Vishwanath, Ingrid Hopper, Geoffrey C. Cloud, Trevor T-J Chong, Raj C. Shah, Geoffrey A. Donnan, Jeff D. Williamson, Charles B. Eaton, Rory Wolfe, Christopher M. Reid, Andrew M. Tonkin, Suzanne G. Orchard, Sharyn Fitzgerald, Anne M. Murray, Robyn L. Woods, Mark R. Nelson…
    Citation: Alzheimer's Research & Therapy 2024 16:111
  4. Plasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited for secondary prevention programs in self-sufficient persons at-risk of dementia. Plasma bio...

    Authors: Augusto J. Mendes, Federica Ribaldi, Aurelien Lathuiliere, Nicholas J. Ashton, Henrik Zetterberg, Marc Abramowicz, Max Scheffler, Frédéric Assal, Valentina Garibotto, Kaj Blennow and Giovanni B. Frisoni
    Citation: Alzheimer's Research & Therapy 2024 16:110
  5. As one major symptom of Alzheimer’s disease (AD), anterograde amnesia describes patients with an inability in new memory formation. The crucial role of the entorhinal cortex in forming new memories has been we...

    Authors: Nan Zhang, Yixuan Sui, Peter Jendrichovsky, Hemin Feng, Heng Shi, Xu Zhang, Shenghui Xu, Wenjian Sun, Huatang Zhang, Xi Chen, Micky D. Tortorella and Jufang He
    Citation: Alzheimer's Research & Therapy 2024 16:109
  6. Sporadic cerebral amyloid angiopathy (sCAA) is a disease characterised by the progressive deposition of the amyloid beta (Aβ) in the cerebral vasculature, capable of causing a variety of symptoms, from (mild) ...

    Authors: Marc Vervuurt, H. Bea Kuiperij, Anna M. de Kort, Iris Kersten, Catharina J. M. Klijn, Floris H. B. M. Schreuder and Marcel M. Verbeek
    Citation: Alzheimer's Research & Therapy 2024 16:108
  7. The recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the future of diagnosis and management of Alzheimer’s disease (AD) and other neurodegenerat...

    Authors: Daniele Altomare, Ilenia Libri, Antonella Alberici, Jasmine Rivolta, Alessandro Padovani, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow and Barbara Borroni
    Citation: Alzheimer's Research & Therapy 2024 16:107
  8. Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urat...

    Authors: Tingjing Zhang, Yu An, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu and Yang Xia
    Citation: Alzheimer's Research & Therapy 2024 16:106
  9. Alzheimer disease (AD) is a major health problem of aging, with tremendous burden on healthcare systems, patients, and families globally. Lecanemab, an FDA-approved amyloid beta (Aβ)-directed antibody indicate...

    Authors: Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry and Lynn Kramer
    Citation: Alzheimer's Research & Therapy 2024 16:105
  10. Optimal blood pressure (BP) levels to reduce the long-term risk of cognitive decline remains controversial. We aimed to investigate the association between BP and anti-hypertensive treatment status with cognit...

    Authors: Haibin Li, Man Wang, Frank Qian, Zhiyuan Wu, Weida Liu, Anxin Wang and Xiuhua Guo
    Citation: Alzheimer's Research & Therapy 2024 16:104
  11. The role of α-synuclein in dementia has been recognized, yet its exact influence on cognitive decline in non-demented older adults is still not fully understood.

    Authors: Wenying Liu, Wenwen Li, Zhaojun Liu, Yan Li, Xuechu Wang, Mengmeng Guo, Shiyuan Wang, Shuheng Wang, Yan Li and Jianping Jia
    Citation: Alzheimer's Research & Therapy 2024 16:103
  12. Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment...

    Authors: Kitty K. Lui, Abhishek Dave, Kate E. Sprecher, Miranda G. Chappel-Farley, Brady A. Riedner, Margo B. Heston, Chase E. Taylor, Cynthia M. Carlsson, Ozioma C. Okonkwo, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin, Bryce A. Mander and Ruth M. Benca
    Citation: Alzheimer's Research & Therapy 2024 16:102
  13. In Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the pathogenesis of the disease. Identifying approaches to specifically target...

    Authors: Caden M. Henningfield, Neelakshi Soni, Ryan W. Lee, Rishi Sharma, Jeffrey L. Cleland and Kim N. Green
    Citation: Alzheimer's Research & Therapy 2024 16:101
  14. Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...

    Authors: Marco Egle, Jennifer A. Deal, Keenan A. Walker, Dean F. Wong, A. Richey Sharrett and Rebecca F. Gottesman
    Citation: Alzheimer's Research & Therapy 2024 16:100
  15. Patients with sporadic cerebral amyloid angiopathy (sCAA) frequently report cognitive or neuropsychiatric symptoms. The aim of this study is to investigate whether in patients with sCAA, cognitive impairment a...

    Authors: Anna M. De Kort, Kanishk Kaushik, H. Bea Kuiperij, Lieke Jäkel, Hao Li, Anil M. Tuladhar, Gisela M. Terwindt, Marieke J. H. Wermer, Jurgen A. H. R. Claassen, Catharina J. M. Klijn, Marcel M. Verbeek, Roy P. C. Kessels and Floris H. B. M. Schreuder
    Citation: Alzheimer's Research & Therapy 2024 16:99
  16. The identification and staging of Alzheimer’s Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts w...

    Authors: Francesca Conca, Valentina Esposito, Eleonora Catricalà, Rosa Manenti, Federica L’Abbate, Davide Quaranta, Guido Maria Giuffrè, Federica Rossetto, Federica Solca, Beatrice Orso, Emanuela Inguscio, Valeria Crepaldi, Maddalena De Matteis, Emanuela Rotondo, Marina Manera, Giulia Caruso…
    Citation: Alzheimer's Research & Therapy 2024 16:98
  17. The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages of Alzheimer’s disease (AD). Little is known about LC and NBM alteration in limbic-predominant age-related TDP-43 e...

    Authors: Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Camille Noiray, Stéphane Lehericy, Romain Valabrègue, Fabien Caillé, Philippe Gervais, Martin Moussion, Michel Bottlaender and Marie Sarazin
    Citation: Alzheimer's Research & Therapy 2024 16:97
  18. Irregular word reading has been used to estimate premorbid intelligence in Alzheimer’s disease (AD) dementia. However, reading models highlight the core influence of semantic abilities on irregular word readin...

    Authors: Anna Marier, Mahsa Dadar, Florence Bouhali and Maxime Montembeault
    Citation: Alzheimer's Research & Therapy 2024 16:96
  19. Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD). The natural psychedelic N, N-...

    Authors: Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang and Zhang-Jin Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:95
  20. Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future b...

    Authors: Heather E. Dark, Yang An, Michael R. Duggan, Cassandra Joynes, Christos Davatzikos, Guray Erus, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick and Keenan A. Walker
    Citation: Alzheimer's Research & Therapy 2024 16:94
  21. Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biological endpoints. Fluid-based biomarkers may present a solution to measure biologically relevan...

    Authors: Marlies Oosthoek, Lisa Vermunt, Arno de Wilde, Bram Bongers, Daniel Antwi-Berko, Philip Scheltens, Pieter van Bokhoven, Everard G. B. Vijverberg and Charlotte E. Teunissen
    Citation: Alzheimer's Research & Therapy 2024 16:93
  22. Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ 65) exhibit distinct features. Understanding the risk factors for dementia development and mortality in EOD and LOD respecti...

    Authors: Min Young Chun, Wonjeong Chae, Sang Won Seo, Hyemin Jang, Jihwan Yun, Duk L. Na, Dongwoo Kang, Jungkuk Lee, Dustin B. Hammers, Liana G. Apostolova, Sung-In Jang and Hee Jin Kim
    Citation: Alzheimer's Research & Therapy 2024 16:92
  23. Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cognitive function and dementia generates significant concern. This study aimed to investigate...

    Authors: Yujin Park, Su Hwan Kim, Jiwon Ryu and Hyung-Jin Yoon
    Citation: Alzheimer's Research & Therapy 2024 16:91
  24. Plasma neurofilament light chain (NfL) is a promising biomarker of neurodegeneration with potential clinical utility in monitoring the progression of neurodegenerative diseases. However, the cross-sectional as...

    Authors: Rongxiang Tang, Erik Buchholz, Anders M. Dale, Robert A. Rissman, Christine Fennema-Notestine, Nathan A. Gillespie, Donald J Hagler Jr, Michael J. Lyons, Michael C. Neale, Matthew S. Panizzon, Olivia K. Puckett, Chandra A. Reynolds, Carol E. Franz, William S. Kremen and Jeremy A. Elman
    Citation: Alzheimer's Research & Therapy 2024 16:90
  25. Alzheimer’s disease is characterized by large-scale structural changes in a specific pattern. Recent studies developed morphological similarity networks constructed by brain regions similar in structural featu...

    Authors: Ting-Yu Chen, Jun-Ding Zhu, Shih-Jen Tsai and Albert C. Yang
    Citation: Alzheimer's Research & Therapy 2024 16:88
  26. While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR’s stability ...

    Authors: Hao Chen, Jin Hu, Shiqi Gui, Qiushuo Li, Jing Wang, Xing Yang and Jingyuan Yang
    Citation: Alzheimer's Research & Therapy 2024 16:87
  27. Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studie...

    Authors: Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Anna M. de Kort, Thijs W. van Harten, Ellis S. van Etten, Erik W. van Zwet, Erik Stoops, Cindy Francois, Bea H. Kuiperij, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Louise van der Weerd, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Marcel M. Verbeek…
    Citation: Alzheimer's Research & Therapy 2024 16:86
  28. Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damage to the insula has been associated with disorders reflecting impairments of the most f...

    Authors: Alice Tisserand, Frédéric Blanc, Mary Mondino, Candice Muller, Hélène Durand, Catherine Demuynck, Paulo Loureiro de Sousa, Alix Ravier, Léa Sanna, Anne Botzung and Nathalie Philippi
    Citation: Alzheimer's Research & Therapy 2024 16:85
  29. The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge of Alzheimer’s disease (AD). However, the characteristics and prevalence of AD in th...

    Authors: Zhen Liu, Dai Shi, Yue Cai, Anqi Li, Guoyu Lan, Pan Sun, Lin Liu, Yalin Zhu, Jie Yang, Yajing Zhou, Lizhi Guo, Laihong Zhang, Shuqing Deng, Shuda Chen, Xianfeng Yu, Xuhui Chen…
    Citation: Alzheimer's Research & Therapy 2024 16:84
  30. The worldwide trend of demographic aging highlights the progress made in healthcare, albeit with health challenges like Alzheimer’s Disease (AD), prevalent in individuals aged 65 and above. Its early detection...

    Authors: Joel Eyamu, Wuon-Shik Kim, Kahye Kim, Kun Ho Lee and Jaeuk U. Kim
    Citation: Alzheimer's Research & Therapy 2024 16:83
  31. Previous studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which relied on the discovery of early diagnostic biomarkers. In this study,...

    Authors: Xiaoling Wang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Qian Zhang, Yingzhen Zhang, Yujian Fan, Jianping Jia and Peichang Wang
    Citation: Alzheimer's Research & Therapy 2024 16:82
  32. Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the pre...

    Authors: Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi and Gábor Csukly
    Citation: Alzheimer's Research & Therapy 2024 16:81
  33. In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discha...

    Authors: Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B. Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar and Kristian Steen Frederiksen
    Citation: Alzheimer's Research & Therapy 2024 16:80
  34. The hypothesis of decreased neural inhibition in dementia has been sparsely studied in functional magnetic resonance imaging (fMRI) data across patients with different dementia subtypes, and the role of social...

    Authors: Sebastian Moguilner, Rubén Herzog, Yonatan Sanz Perl, Vicente Medel, Josefina Cruzat, Carlos Coronel, Morten Kringelbach, Gustavo Deco, Agustín Ibáñez and Enzo Tagliazucchi
    Citation: Alzheimer's Research & Therapy 2024 16:79
  35. Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD). Numerous studies have asserted a close association between neuroinflammation ...

    Authors: Chang Liu, Alfredo Cárdenas-Rivera, Shayna Teitelbaum, Austin Birmingham, Mohammed Alfadhel and Mohammad A. Yaseen
    Citation: Alzheimer's Research & Therapy 2024 16:78
  36. Individuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A + T +), display a rapid cognitive decline and elevated disease progression risk. However, limite...

    Authors: Motonobu Fujishima, Yohei Kawasaki, Toshiharu Mitsuhashi and Hiroshi Matsuda
    Citation: Alzheimer's Research & Therapy 2024 16:77
  37. Both memory clinic professionals and patients see value in digital tools, yet these hardly find their way to clinical practice. We explored the usability of a digital tool to support the diagnostic work-up in ...

    Authors: Aniek M. van Gils, Hanneke F. M. Rhodius-Meester, Dédé Handgraaf, Heleen M. A. Hendriksen, Astrid van Strien, Niki Schoonenboom, Annemieke Schipper, Mariska Kleijer, Annemiek Griffioen, Majon Muller, Antti Tolonen, Jyrki Lötjönen, Wiesje M. van der Flier and Leonie N. C. Visser
    Citation: Alzheimer's Research & Therapy 2024 16:75
  38. Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes of intracerebral hemorrhage (ICH) and dementia in the elderly, remains unclea...

    Authors: Kanishk Kaushik, Anna M. de Kort, Rosemarie van Dort, Reinier G.J. van der Zwet, Bob Siegerink, Sabine Voigt, Erik W. van Zwet, Maaike C. van der Plas, Emma A. Koemans, Ingeborg Rasing, Roy P.C. Kessels, Huub A.M. Middelkoop, Floris H.B.M. Schreuder, Catharina J.M. Klijn, Marcel M. Verbeek, Gisela M. Terwindt…
    Citation: Alzheimer's Research & Therapy 2024 16:74
  39. Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI can support the clinical profile. Visual rating scales are a simple and reliable tool to assess b...

    Authors: Neus Falgàs, Luca Sacchi, Tiziana Carandini, Nuria Montagut, Giorgio Conte, Fabio Triulzi, Daniela Galimberti, Andrea Arighi, Raquel Sanchez-Valle and Giorgio Giulio Fumagalli
    Citation: Alzheimer's Research & Therapy 2024 16:73
  40. Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in sporadic behavioral variant frontotemporal dementia (bvFTD) remains un...

    Authors: Min Chu, Deming Jiang, Haitian Nan, Lulu Wen, Li Liu, Miao Qu and Liyong Wu
    Citation: Alzheimer's Research & Therapy 2024 16:72
  41. The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’...

    Authors: Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe and Ian F. Harrison
    Citation: Alzheimer's Research & Therapy 2024 16:71
  42. Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studi...

    Authors: Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane and Malcolm A. Leissring
    Citation: Alzheimer's Research & Therapy 2024 16:70
  43. Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the asso...

    Authors: Qingze Zeng, Yanbo Wang, Shuyue Wang, Xiao Luo, Kaicheng Li, Xiaopei Xu, Xiaocao Liu, Luwei Hong, Jixuan Li, Zheyu Li, Xinyi Zhang, Siyan Zhong, Zhirong Liu, Peiyu Huang, Yanxing Chen and Minming Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:69
  44. Mounting data suggests that herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of AD, possibly instigating amyloid-beta (Aβ) accumulation decades before the onset of clinical symptoms. However...

    Authors: Jose L. Cantero, Mercedes Atienza, Isabel Sastre and María Jesús Bullido
    Citation: Alzheimer's Research & Therapy 2024 16:68
  45. White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial h...

    Authors: Dario Bachmann, Bettina von Rickenbach, Andreas Buchmann, Martin Hüllner, Isabelle Zuber, Sandro Studer, Antje Saake, Katrin Rauen, Esmeralda Gruber, Roger M. Nitsch, Christoph Hock, Valerie Treyer and Anton Gietl
    Citation: Alzheimer's Research & Therapy 2024 16:67
  46. Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This h...

    Authors: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti…
    Citation: Alzheimer's Research & Therapy 2024 16:66
  47. It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adult...

    Authors: Shan Yin, Pei-Yang Gao, Ya-Nan Ou, Yan Fu, Ying Liu, Zuo-Teng Wang, Bao-Lin Han and Lan Tan
    Citation: Alzheimer's Research & Therapy 2024 16:65
  48. Posterior cortical atrophy (PCA) is a form of dementia that frequently displays significant visual dysfunction and relatively preserved cognitive and executive functions, thus hindering early diagnosis and tre...

    Authors: Yan Sun, Lumi Zhang, Hui Ye, Lumin Leng, Yi Chen, Yujie Su, Peifang Ren, Hong Lu and Guoping Peng
    Citation: Alzheimer's Research & Therapy 2024 16:64