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  1. Research

    The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial

    Synaptic dysfunction contributes to cognitive impairment in Alzheimer’s disease and may be countered by increased intake of nutrients that target brain phospholipid metabolism. In this study, we explored wheth...

    Anne Rijpma, Marinette van der Graaf, Marieke M. Lansbergen, Olga Meulenbroek, Aysun Cetinyurek-Yavuz, John W. Sijben, Arend Heerschap and Marcel G. M. Olde Rikkert

    Alzheimer's Research & Therapy 2017 9:51

    Published on: 26 July 2017

  2. Research

    No added diagnostic value of non-phosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis

    The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel)...

    Joery Goossens, Maria Bjerke, Hanne Struyfs, Ellis Niemantsverdriet, Charisse Somers, Tobi Van den Bossche, Sara Van Mossevelde, Bart De Vil, Anne Sieben, Jean-Jacques Martin, Patrick Cras, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee and Sebastiaan Engelborghs

    Alzheimer's Research & Therapy 2017 9:49

    Published on: 14 July 2017

  3. Research

    A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

    CAD-31 is an Alzheimer’s disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/...

    Daniel Daugherty, Joshua Goldberg, Wolfgang Fischer, Richard Dargusch, Pamela Maher and David Schubert

    Alzheimer's Research & Therapy 2017 9:50

    Published on: 14 July 2017

  4. Research

    Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults

    This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) and cerebrovascular injury across the life spa...

    Ge Li, Jane B. Shofer, Eric C. Petrie, Chang-En Yu, Charles W. Wilkinson, Dianne P. Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J. Montine, Murray A. Raskind, Joseph F. Quinn, Douglas R. Galasko and Elaine R. Peskind

    Alzheimer's Research & Therapy 2017 9:48

    Published on: 3 July 2017

  5. Research

    Long-term cognitive outcome of Alzheimer’s disease and dementia with Lewy bodies: dual disease is worse

    Longitudinal studies of dementia with Lewy bodies (DLB) are rare. Clinically, DLB is usually considered to worsen into Alzheimer’s disease (AD). The aim of our study was to compare the rate of the cognitive de...

    Frédéric Blanc, Rachid Mahmoudi, Thérèse Jonveaux, Jean Galmiche, Gilles Chopard, Benjamin Cretin, Catherine Demuynck, Catherine Martin-Hunyadi, Nathalie Philippi, François Sellal, Jean-Marc Michel, Gregory Tio, Melanie Stackfleth, Pierre Vandel, Eloi Magnin, Jean-Luc Novella…

    Alzheimer's Research & Therapy 2017 9:47

    Published on: 27 June 2017

  6. Research

    Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments

    The original paper Self-Administered Gerocognitive Examination (SAGE) is a valid and reliable cognitive assessment tool used to identify individuals with mild cognitive impairment (MCI) or early dementia. We e...

    Douglas W. Scharre, Shu ing Chang, Haikady N. Nagaraja, Nicole E. Vrettos and Robert A. Bornstein

    Alzheimer's Research & Therapy 2017 9:44

    Published on: 27 June 2017

  7. Research

    Oligomeric tau-targeted immunotherapy in Tg4510 mice

    Finding ways to reverse or prevent the consequences of pathogenic tau in the brain is of considerable importance for treatment of Alzheimer’s disease and other tauopathies. Immunotherapy against tau has shown ...

    Sulana Schroeder, Aurelie Joly-Amado, Ahlam Soliman, Urmi Sengupta, Rakiz Kayed, Marcia N. Gordon and David Morgan

    Alzheimer's Research & Therapy 2017 9:46

    Published on: 27 June 2017

  8. Research

    One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

    Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway. The in...

    Loïc Dayon, Seu Ping Guiraud, John Corthésy, Laeticia Da Silva, Eugenia Migliavacca, Domilė Tautvydaitė, Aikaterini Oikonomidi, Barbara Moullet, Hugues Henry, Sylviane Métairon, Julien Marquis, Patrick Descombes, Sebastiano Collino, François-Pierre J. Martin, Ivan Montoliu, Martin Kussmann…

    Alzheimer's Research & Therapy 2017 9:43

    Published on: 17 June 2017

  9. Review

    Stem cell models of Alzheimer’s disease: progress and challenges

    A major challenge to our understanding of the molecular mechanisms of Alzheimer’s disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cel...

    Charles Arber, Christopher Lovejoy and Selina Wray

    Alzheimer's Research & Therapy 2017 9:42

    Published on: 13 June 2017

  10. Research article

    A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

    β-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s disease (AD) development, and Aβ monomers have normal physiological function. The antibodies or vaccines against Aβ monomers have...

    Shao-wei Wang, Dong-qun Liu, Ling-xiao Zhang, Mei Ji, Yang-xin Zhang, Quan-xiu Dong, Shu-ying Liu, Xi-xiu Xie and Rui-tian Liu

    Alzheimer's Research & Therapy 2017 9:41

    Published on: 7 June 2017

  11. Research

    Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial

    Spaced retrieval training (SRT) is a nonpharmacological intervention for mild cognitive impairment (MCI) and dementia that trains the learning and retention of target information by recalling it over increasin...

    Ji Won Han, Kyung Lak Son, Hye Jin Byun, Ji Won Ko, Kayoung Kim, Jong Woo Hong, Tae Hyun Kim and Ki Woong Kim

    Alzheimer's Research & Therapy 2017 9:39

    Published on: 6 June 2017

  12. Research

    Recommendations for cerebrospinal fluid collection for the analysis by ELISA of neurogranin trunc P75, α-synuclein, and total tau in combination with Aβ(1–42)/Aβ(1–40)

    The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain patholog...

    Hugo Vanderstichele, Leentje Demeyer, Shorena Janelidze, Els Coart, Erik Stoops, Kimberley Mauroo, Victor Herbst, Cindy François and Oskar Hansson

    Alzheimer's Research & Therapy 2017 9:40

    Published on: 6 June 2017

  13. Research

    Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

    Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo...

    Claire Bridel, Torsten Hoffmann, Antje Meyer, Sisi Durieux, Marleen A. Koel-Simmelink, Matthias Orth, Philip Scheltens, Inge Lues and Charlotte E. Teunissen

    Alzheimer's Research & Therapy 2017 9:38

    Published on: 6 June 2017

  14. Research

    Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

    A lot of attention has been paid to the relationship of blood pressure and dementia because epidemiological research has reported conflicting evidence. Observational data has shown that midlife hypertension is...

    Jessica Mira Gabin, Kristian Tambs, Ingvild Saltvedt, Erik Sund and Jostein Holmen

    Alzheimer's Research & Therapy 2017 9:37

    Published on: 31 May 2017

  15. Research

    Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden

    The complexity of medication therapy in older adults with multiple comorbidities often leads to inappropriate prescribing. Drugs with anticholinergic properties are of particular interest because many are not ...

    Daniela C. Moga, Erin L. Abner, Dorinda N. Rigsby, Lynne Eckmann, Mark Huffmyer, Richard R. Murphy, Beth B. Coy and Gregory A. Jicha

    Alzheimer's Research & Therapy 2017 9:36

    Published on: 23 May 2017

  16. Review

    Communicating mild cognitive impairment diagnoses with and without amyloid imaging

    Mild cognitive impairment (MCI) has an uncertain etiology and prognosis and may be challenging for clinicians to discuss with patients and families. Amyloid imaging may aid specialists in determining MCI etiol...

    Joshua D. Grill, Liana G. Apostolova, Szofia Bullain, Jeffrey M. Burns, Chelsea G. Cox, Malcolm Dick, Dean Hartley, Claudia Kawas, Sarah Kremen, Jennifer Lingler, Oscar L. Lopez, Mark Mapstone, Aimee Pierce, Gil Rabinovici, J. Scott Roberts, Seyed Ahmad Sajjadi…

    Alzheimer's Research & Therapy 2017 9:35

    Published on: 4 May 2017

  17. Research

    Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study

    Safety warnings from health authorities are currently intended to limit the use of antipsychotics (APs) in dementia-related conditions to treat neuropsychiatric symptoms, such as disturbing and/or delusional b...

    Karim Tifratene, Valeria Manera, Roxane Fabre, Auriane Gros, Susanne Thummler, Christian Pradier, Philippe Robert and Renaud David

    Alzheimer's Research & Therapy 2017 9:34

    Published on: 26 April 2017

  18. Research

    Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

    The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in diagnosing Alzheimer’s disease (AD) and predicting the cognitive evolution of p...

    Fayçal Ben Bouallègue, Denis Mariano-Goulart and Pierre Payoux

    Alzheimer's Research & Therapy 2017 9:32

    Published on: 26 April 2017

  19. Research

    Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

    Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptid...

    Doris Lambracht-Washington, Min Fu, Pat Frost and Roger N. Rosenberg

    Alzheimer's Research & Therapy 2017 9:30

    Published on: 26 April 2017

  20. Research

    Memory is preserved in older adults taking AT1 receptor blockers

    Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer’s disease, independent of stroke. Angiotensin II receptor blockers (ARBs) have been highlighte...

    Jean K. Ho and Daniel A. Nation

    Alzheimer's Research & Therapy 2017 9:33

    Published on: 26 April 2017

  21. Review

    The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

    Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influen...

    Sarah Westwood, Benjamine Liu, Alison L. Baird, Sneha Anand, Alejo J. Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R. Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso…

    Alzheimer's Research & Therapy 2017 9:31

    Published on: 26 April 2017

  22. Research

    Multireceptor fingerprints in progressive supranuclear palsy

    Progressive supranuclear palsy (PSP) with a frontal presentation, characterized by cognitive deficits and behavioral changes, has been recognized as an early clinical picture, distinct from the classical so-ca...

    Wang Zheng Chiu, Laura Donker Kaat, Agnita J. W. Boon, Wouter Kamphorst, Axel Schleicher, Karl Zilles, John C. van Swieten and Nicola Palomero-Gallagher

    Alzheimer's Research & Therapy 2017 9:28

    Published on: 17 April 2017

  23. Review

    The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

    Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at risk,...

    Alberto Costa, Thomas Bak, Paolo Caffarra, Carlo Caltagirone, Mathieu Ceccaldi, Fabienne Collette, Sebastian Crutch, Sergio Della Sala, Jean François Démonet, Bruno Dubois, Emrah Duzel, Peter Nestor, Sokratis G. Papageorgiou, Eric Salmon, Sietske Sikkes, Pietro Tiraboschi…

    Alzheimer's Research & Therapy 2017 9:27

    Published on: 17 April 2017

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