Articles

Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain.

Authors: Si Zhang, Jiehao Zhao, Yuhu Zhang, Yun Zhang, Fang Cai, Lijuan Wang and Weihong Song

Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimo...

Authors: Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lötjönen, Esko Levälahti, Riitta Parkkola, Pauliina Pippola, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Miia Kivipelto…

Avoiding methodological bias in studies of amyloid imaging results disclosure

Authors: Carl Taswell, Cheryl Donohue, Maree T. Mastwyk, Andrea G. Louey, Jacqueline Giummarra, Joanne Robertson, David G. Darby, Colin L. Masters and Christopher C. Rowe

Response to “Avoiding Methodological Bias in Studies of Amyloid Imaging Results Disclosure”

Authors: Joshua D. Grill, Chelsea G. Cox, Kristin Harkins and Jason Karlawish

Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers

Subjective cognitive decline (SCD) is characterized by self-reported cognitive deficits without measurable cognitive impairment. It has been suggested that individuals with SCD exhibited brain structural alter...

Authors: Yu Sun, Xiaoni Wang, Yinshan Wang, Haoming Dong, Jie Lu, Tohar Scheininger, Michael Ewers, Frank Jessen, Xi-Nian Zuo and Ying Han

Electrophysiological brain signatures for the classification of subjective cognitive decline: towards an individual detection in the preclinical stages of dementia

Alzheimer’s disease (AD) prevalence is rapidly growing as worldwide populations grow older. Available treatments have failed to slow down disease progression, thus increasing research focus towards early or pr...

Authors: David López-Sanz, Ricardo Bruña, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos-Dolado, Fernando Maestú and Stefan Walter

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study

Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia and are associated with various disadvantageous clinical outcomes includin...

Authors: Willem S. Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L. van Bruchem, Jeannette A. Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer, Jan J. M. Driesen, Lilian J. H. M. Vroegindeweij, Elsbeth C. Thomeer, Susanne E. Hoogers, Anke A. Dijkstra, Sytse U. Zuidema…

The association of vascular disorders with incident dementia in different age groups

There is increasing evidence that dementia risk associated with vascular disorders is age dependent. Large population-based studies of incident dementia are necessary to further elucidate this effect. Therefor...

Authors: Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier and Pieter Jelle Visser

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer’s disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an u...

Authors: Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez and Alfredo J. Miñano-Molina

Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort

The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest re...

Authors: Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, André Aleman, Craig W. Ritchie, Philip Scheltens and Sietske A. M. Sikkes

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cereb...

Authors: Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens and Cheryl L. Wellington

Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study

Studies in older adults or those with cognitive impairment have shown associations between cognitive and olfactory performance, but there are few population-based studies especially in younger adults. We there...

Authors: Maryam Yahiaoui-Doktor, Tobias Luck, Steffi G. Riedel-Heller, Markus Loeffler, Kerstin Wirkner and Christoph Engel

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer’s disease has been widely studied, ...

Authors: Sofía Fernández de Retana, Paula Marazuela, Montse Solé, Guillem Colell, Anna Bonaterra, Jose Luis Sánchez-Quesada, Joan Montaner, Daniel Maspoch, Mary Cano-Sarabia and Mar Hernández-Guillamon

Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA

Semantic variant of primary progressive aphasia (svPPA) is a subtype of frontotemporal dementia characterized by asymmetric temporal atrophy.

Authors: Martina Bocchetta, Juan Eugenio Iglesias, Lucy L. Russell, Caroline V. Greaves, Charles R. Marshall, Marzia A. Scelsi, David M. Cash, Sebastien Ourselin, Jason D. Warren and Jonathan D. Rohrer

Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease

Oligomeric amyloid-ß is a major toxic species associated with Alzheimer’s disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased in number in recent years. The Multimer ...

Authors: Young Chul Youn, Sungmin Kang, Jeewon Suh, Young Ho Park, Min Ju Kang, Jung-Min Pyun, Seong Hye Choi, Jee Hyang Jeong, Kyung Won Park, Ho-Won Lee, Seong Soo A. An, Jacqueline C. Dominguez and SangYun Kim

Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Following publication of the original article [1], the authors reported that Fig. 6 contains a mistake. The Fig. 6F is a duplicate of Fig. 6E of Braak 5.

Authors: Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan and Qing-Rong Liu

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease

Discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in Alzheimer’s disease.

Authors: Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau and Bente Finsen

Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial

High-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose at the risk of increasing cholinergic side effects. However, the advers...

Authors: Yun Jeong Hong, Hyun Jeong Han, Young Chul Youn, Kyung Won Park, Dong Won Yang, SangYun Kim, Hwa Jung Kim, Ji Eun Kim and Jae-Hong Lee

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of...

Authors: Miranka Wirth, Claudia Schwarz, Gloria Benson, Nora Horn, Ralph Buchert, Catharina Lange, Theresa Köbe, Stefan Hetzer, Marta Maglione, Eva Michael, Stefanie Märschenz, Knut Mai, Ute Kopp, Dietmar Schmitz, Ulrike Grittner, Stephan J. Sigrist…

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Alzheimer’s disease (AD) is responsible for 60–70% of all cases of dementia. On the other hand, the tap water consumed by hundreds of millions of people has been fluoridated to prevent tooth decay. However, li...

Authors: Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Yi Li, Hui Song, Xiao-Xiao Zeng, Long-Yan Ran, Wei Hong and Zhi-Zhong Guan

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ₄₂), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau₁₈₁) have proven diagnostic accuracy for mild cognitive impairmen...

Authors: Oskar Hansson, Sylvain Lehmann, Markus Otto, Henrik Zetterberg and Piotr Lewczuk

Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project

Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage take...

Authors: Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof…

Risk of suicide and accidental deaths among elderly patients with cognitive impairment

The leading causes of death among the elderly with cognitive impairment are unknown. This study aims to estimate the suicide and accidental death rates on the basis of a clinical case registry of patients diag...

Authors: Ji Hyun An, Kyung Eun Lee, Hong Jin Jeon, Sang Joon Son, Sung Yoon Kim and Jin Pyo Hong

Risk of dementia in patients with end-stage renal disease under maintenance dialysis—a nationwide population-based study with consideration of competing risk of mortality

Dementia is prevalent in the end-stage renal disease (ESRD) population. However, it is still not clarified whether ESRD is one of the etiology of dementia or its attributable effect on the cumulative risk of d...

Authors: Yi-Ting Kuo, Chung-Yi Li, Junne-Ming Sung, Chiung-Chih Chang, Jung-Der Wang, Chien-Yao Sun, Jia-Ling Wu and Yu-Tzu Chang

Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review

The phenocopy syndrome of behavioral variant of frontotemporal dementia (phFTD) refers to patients presenting with neuropsychiatric symptoms mimicking the behavioral variant frontotemporal dementia (bvFTD), bu...

Authors: Elizabeth Sakamoto Valente, Paulo Caramelli, Leandro Boson Gambogi, Luciano Inácio Mariano, Henrique Cerqueira Guimarães, Antônio Lúcio Teixeira and Leonardo Cruz de Souza

CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

Alzheimer’s disease (AD) is the sixth leading cause of death, with an average survival estimated between 5 and 10 years after diagnosis. Despite recent advances in diagnostic criteria of AD, few studies have u...

Authors: Adla Boumenir, Emmanuel Cognat, Severine Sabia, Claire Hourregue, Matthieu Lilamand, Aline Dugravot, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Jacques Hugon, Archana Singh-Manoux, Claire Paquet and Julien Dumurgier

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1, NRXN2, and NRXN3, are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release. Neurex...

Authors: Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan and Qing-Rong Liu

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making fo...

Authors: Gemma Salvadó, José Luis Molinuevo, Anna Brugulat-Serrat, Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Javier Pavia, Aida Niñerola-Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow and Juan Domingo Gispert

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer’s disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding r...

Authors: Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye and André Strydom

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

In clinical practice, it is often difficult to predict which patients with cognitive complaints or impairment will progress or remain stable. We assessed the impact of using a clinical decision support system,...

Authors: Marie Bruun, Kristian S. Frederiksen, Hanneke F. M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Daniel Rueckert, Nadia Dyremose, Birgitte B. Andersen, Afina W. Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka…

Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study

Although previous studies have revealed many factors related to mild cognitive impairment (MCI) reversion, information about reversible factors related MCI reversion is limited, impeding the development of int...

Authors: Hiroyuki Shimada, Takehiko Doi, Sangyoon Lee and Hyuma Makizako

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings

The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator’s meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient acces...

Authors: Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly…

Concepts for brain aging: resistance, resilience, reserve, and compensation

A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling life while many others are robbed of their independen...

Authors: Thomas J. Montine, Brenna A. Cholerton, Maria M. Corrada, Steven D. Edland, Margaret E. Flanagan, Laura S. Hemmy, Claudia H. Kawas and Lon R. White

Brief cognitive screening instruments for early detection of Alzheimer’s disease: a systematic review

The objective of this systematic review was (1) to give an overview of the available short screening instruments for the early detection of Alzheimer’s disease (AD) and (2) to review the psychometric propertie...

Authors: Ellen Elisa De Roeck, Peter Paul De Deyn, Eva Dierckx and Sebastiaan Engelborghs

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

[18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes [18F]FDG-PET a valuable tool in the diagnostic workup of neurodeg...

Authors: Silvia Paola Caminiti, Arianna Sala, Leonardo Iaccarino, Luca Beretta, Andrea Pilotto, Luigi Gianolli, Sandro Iannaccone, Giuseppe Magnani, Alessandro Padovani, Luigi Ferini-Strambi and Daniela Perani

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease

To investigate how serum neurofilament light (NfL) concentration changes through the course of disease in familial Alzheimer’s disease (FAD) and to assess when NfL concentration first increases.

Authors: Philip S. J. Weston, Teresa Poole, Antoinette O’Connor, Amanda Heslegrave, Natalie S. Ryan, Yuying Liang, Ronald Druyeh, Simon Mead, Kaj Blennow, Jonathan M. Schott, Chris Frost, Henrik Zetterberg and Nick C. Fox

Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease

There are currently no approved treatments for the prodromal stage of Alzheimer’s disease (AD). Approved symptomatic treatments for mild-to-moderate AD include acetylcholinesterase inhibitors and memantine, bu...

Authors: Lutz Frölich, Glen Wunderlich, Claus Thamer, Michael Roehrle, Miguel Garcia Jr and Bruno Dubois

Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease

Autosomal dominant Alzheimer’s disease (ADAD) is distinguished from late-onset AD by early striatal amyloid-β deposition. To determine whether striatal Pittsburgh compound B (PiB)-PET measurements of amyloid-β...

Authors: Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Daniel J. Norton, Edmarie Guzman-Velez, Ana Baena, Enmanuelle Pardilla-Delgado, Aaron P. Schultz, Jennifer Gatchel, David Jin, Kewei Chen, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-...

Authors: Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde and Paul J. Whiting

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from...

Authors: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois and Harald Hampel

Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease

A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and pa...

Authors: Omar A. Halawa, Jennifer R. Gatchel, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson and Gad A. Marshall

¹⁸F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

The tau positron emission tomography (PET) ligand ¹⁸F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer’s disease (AD), but its utility in detecting tau aggregates in frontotemporal dem...

Authors: Richard M. Tsai, Alexandre Bejanin, Orit Lesman-Segev, Renaud LaJoie, Adrienne Visani, Viktoriya Bourakova, James P. O’Neil, Mustafa Janabi, Suzanne Baker, Suzee E. Lee, David C. Perry, Lynn Bajorek, Anna Karydas, Salvatore Spina, Lea T. Grinberg, William W. Seeley…

Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer’s disease (AD). This study aims to describe the patterns of WMH associated with dementia...

Authors: Gemma Salvadó, Anna Brugulat-Serrat, Carole H. Sudre, Oriol Grau-Rivera, Marc Suárez-Calvet, Carles Falcon, Karine Fauria, M. Jorge Cardoso, Frederik Barkhof, José Luis Molinuevo and Juan Domingo Gispert

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study

We developed multifactorial models for predicting incident dementia and brain pathology in the oldest old using the Vantaa 85+ cohort.

Authors: Anette Hall, Timo Pekkala, Tuomo Polvikoski, Mark van Gils, Miia Kivipelto, Jyrki Lötjönen, Jussi Mattila, Mia Kero, Liisa Myllykangas, Mira Mäkelä, Minna Oinas, Anders Paetau, Hilkka Soininen, Maarit Tanskanen and Alina Solomon

Data-driven prognostic features of cognitive trajectories in patients with amnestic mild cognitive impairments

Although amnestic mild cognitive impairment (aMCI) is generally considered to be a prodromal stage of Alzheimer’s disease, patients with aMCI show heterogeneous patterns of progression. Moreover, there are few...

Authors: Yeo Jin Kim, Seong-Kyoung Cho, Hee Jin Kim, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Jacob W. Vogel, Duk L. Na, Changsoo Kim and Sang Won Seo

Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: a randomised controlled trial

Complex visual hallucinations are common in Lewy body dementia (LBD) and can cause significant patient and caregiver distress. Current treatments are primarily pharmacological in nature and have limited effica...

Authors: Greg J. Elder, Sean J. Colloby, Michael J. Firbank, Ian G. McKeith and John-Paul Taylor

Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples

Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer’s disease (AD) dementia and as a target population for future...

Authors: Steffen Wolfsgruber, José Luis Molinuevo, Michael Wagner, Charlotte E. Teunissen, Lorena Rami, Nina Coll-Padrós, Femke H. Bouwman, Rosalinde E. R. Slot, Linda M. P. Wesselman, Oliver Peters, Katja Luther, Katharina Buerger, Josef Priller, Christoph Laske, Stefan Teipel, Annika Spottke…

Prevalence and risk of progression of preclinical Alzheimer’s disease stages: a systematic review and meta-analysis

Alzheimer’s disease (AD) pathology begins several years before the clinical onset. The long preclinical phase is composed of three stages according to the 2011National Institute on Aging and Alzheimer’s Associ...

Authors: Lucilla Parnetti, Elena Chipi, Nicola Salvadori, Katia D’Andrea and Paolo Eusebi

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

The annual incidence of traumatic brain injury (TBI) in the United States is over 2.5 million, with approximately 3–5 million people living with chronic sequelae. Compared with moderate-severe TBI, the long-te...

Authors: Wai Hang Cheng, Kris M. Martens, Asma Bashir, Honor Cheung, Sophie Stukas, Ebrima Gibbs, Dhananjay R. Namjoshi, Emily B. Button, Anna Wilkinson, Carlos J. Barron, Neil R. Cashman, Peter A. Cripton and Cheryl L. Wellington

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. De...

Authors: Alireza Nazarian, Anatoliy I. Yashin and Alexander M. Kulminski