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  1. Research

    Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42

    A reliable blood-based assay is required to properly diagnose and monitor Alzheimer’s disease (AD). Many attempts have been made to develop such a diagnostic tool by measuring amyloid-β oligomers (AβOs) in the...

    Seong Soo A. An, Byoung-sub Lee, Ji Sun Yu, Kuntaek Lim, Gwang Je Kim, Ryan Lee, Shinwon Kim, Sungmin Kang, Young Ho Park, Min Jeong Wang, Young Soon Yang, Young Chul Youn and SangYun Kim

    Alzheimer's Research & Therapy 2017 9:86

    Published on: 17 October 2017

  2. Research

    Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

    The progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid (CSF) markers. Since most biomarkers reveal compleme...

    Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff…

    Alzheimer's Research & Therapy 2017 9:84

    Published on: 10 October 2017

  3. Review

    PKR involvement in Alzheimer’s disease

    Brain lesions in Alzheimer’s disease (AD) are characterized by Aβ accumulation, neurofibrillary tangles, and synaptic and neuronal vanishing. According to the amyloid cascade hypothesis, Aβ1-42 oligomers could...

    Jacques Hugon, François Mouton-Liger, Julien Dumurgier and Claire Paquet

    Alzheimer's Research & Therapy 2017 9:83

    Published on: 5 October 2017

  4. Review

    Gene suppression approaches to neurodegeneration

    Gene suppression approaches have emerged over the last 20 years as a novel therapeutic approach for the treatment of neurodegenerative diseases. These include RNA interference and anti-sense oligonucleotides, ...

    Rhia Ghosh and Sarah J. Tabrizi

    Alzheimer's Research & Therapy 2017 9:82

    Published on: 5 October 2017

  5. Research

    Attitudes toward clinical trials across the Alzheimer’s disease spectrum

    Research has revealed that manifest Alzheimer’s disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology is accumulating but function remains intact. This understanding and ...

    Michelle M. Nuño, Daniel L. Gillen, Kulwant K. Dosanjh, Jenny Brook, David Elashoff, John M. Ringman and Joshua D. Grill

    Alzheimer's Research & Therapy 2017 9:81

    Published on: 4 October 2017

  6. Research

    N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

    The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the pres...

    Oliver Wirths, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer and Sascha Weggen

    Alzheimer's Research & Therapy 2017 9:80

    Published on: 4 October 2017

  7. Research

    Metabolic status of CSF distinguishes rats with tauopathy from controls

    Tauopathies represent heterogeneous groups of neurodegenerative diseases that are characterised by abnormal deposition of the microtubule-associated protein tau. Alzheimer’s disease is the most prevalent tauop...

    Radana Karlíková, Kateřina Mičová, Lukáš Najdekr, Alžběta Gardlo, Tomáš Adam, Petra Majerová, David Friedecký and Andrej Kováč

    Alzheimer's Research & Therapy 2017 9:78

    Published on: 21 September 2017

  8. Research

    Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

    The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation of novel therapeutics, yet true alignment of research is challenging...

    Thomas Blackmore, Soraya Meftah, Tracey Karen Murray, Peter James Craig, Anthony Blockeel, Keith Phillips, Brian Eastwood, Michael J. O’Neill, Hugh Marston, Zeshan Ahmed, Gary Gilmour and Francois Gastambide

    Alzheimer's Research & Therapy 2017 9:77

    Published on: 20 September 2017

  9. Research

    Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice

    Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer’s disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD an...

    Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch and Bente Finsen

    Alzheimer's Research & Therapy 2017 9:74

    Published on: 12 September 2017

  10. Research

    Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

    Alzheimer’s disease (AD) impacts men and women differently, but the effect of sex on predementia stages is unclear. The objective of this study was to examine whether sex moderates the impact of florbetapir po...

    Jessica Z. K. Caldwell, Jody-Lynn Berg, Jeffrey L. Cummings and Sarah J. Banks

    Alzheimer's Research & Therapy 2017 9:72

    Published on: 12 September 2017

  11. Review

    Alzheimer’s disease prevention: from risk factors to early intervention

    Due to the progressive aging of the population, Alzheimer’s disease (AD) is becoming a healthcare burden of epidemic proportions for which there is currently no cure. Disappointing results from clinical trials...

    Marta Crous-Bou, Carolina Minguillón, Nina Gramunt and José Luis Molinuevo

    Alzheimer's Research & Therapy 2017 9:71

    Published on: 12 September 2017

  12. Research

    Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

    Amyloid pathology in subjects with mild cognitive impairment (MCI) is an important risk factor for progression to dementia due to Alzheimer’s disease. Predicting the onset of dementia is challenging even in th...

    Mara ten Kate, Frederik Barkhof, Pieter Jelle Visser, Charlotte E. Teunissen, Philip Scheltens, Wiesje M. van der Flier and Betty M. Tijms

    Alzheimer's Research & Therapy 2017 9:73

    Published on: 12 September 2017

  13. Research

    Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

    Polyunsaturated fatty acids play a crucial role in neuronal function, and the modification of these compounds in the brain could have an impact on neurodegenerative diseases such as Alzheimer’s disease. Despit...

    Mélanie H. Thomas, Cédric Paris, Mylène Magnien, Julie Colin, Sandra Pelleïeux, Florence Coste, Marie-Christine Escanyé, Thierry Pillot and Jean-Luc Olivier

    Alzheimer's Research & Therapy 2017 9:69

    Published on: 29 August 2017

  14. Research

    Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

    The natural history and disease mechanisms of Alzheimer’s disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use...

    Carole Dufouil, Bruno Dubois, Bruno Vellas, Florence Pasquier, Frédéric Blanc, Jacques Hugon, Olivier Hanon, Jean-François Dartigues, Sandrine Harston, Audrey Gabelle, Mathieu Ceccaldi, Olivier Beauchet, Pierre Krolak-Salmon, Renaud David, Olivier Rouaud, Olivier Godefroy…

    Alzheimer's Research & Therapy 2017 9:67

    Published on: 29 August 2017

  15. Research

    Cost of diagnosing dementia in a German memory clinic

    Little is known about diagnostic work-ups or the costs of diagnosing dementia in specialized care. Here, we analyzed the costs of diagnosing dementia according to specific dementia disorders.

    Bernhard Michalowsky, Steffen Flessa, Johannes Hertel, Olav Goetz, Wolfgang Hoffmann, Stefan Teipel and Ingo Kilimann

    Alzheimer's Research & Therapy 2017 9:65

    Published on: 22 August 2017

  16. Research

    A coiled conformation of amyloid-β recognized by antibody C706

    β-Amyloid (Aβ) peptide is believed to play a pivotal role in the development of Alzheimer’s disease. Passive immunization with anti-Aβ monoclonal antibodies may facilitate the clearance of Aβ in the brain and ...

    Alexey Teplyakov, Galina Obmolova and Gary L. Gilliland

    Alzheimer's Research & Therapy 2017 9:66

    Published on: 22 August 2017

  17. Review

    Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

    The specific amyloid-beta (Aβ) species or other amyloid-precursor protein cleavage products that are most directly related to human neurodegeneration and clinical dementia of the Alzheimer’s type have not yet ...

    David L. Brody, Hao Jiang, Norelle Wildburger and Thomas J. Esparza

    Alzheimer's Research & Therapy 2017 9:62

    Published on: 17 August 2017

  18. Research

    Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

    Mixed vascular and neurodegenerative dementia, such as Alzheimer’s disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment. The brain white m...

    Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen and Juan Zhou

    Alzheimer's Research & Therapy 2017 9:63

    Published on: 17 August 2017

  19. Research

    Associations of thyroid hormone serum levels with in-vivo Alzheimer’s disease pathologies

    The present study investigated the relationships between thyroid hormone serum levels or thyroid-stimulating hormone (TSH) and two Alzheimer’s disease (AD)-specific biomarkers, cerebral amyloid beta (Aβ) burde...

    Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Jun Ho Lee, Jun-Young Lee, Yu Kyung Kim and Dong Young Lee

    Alzheimer's Research & Therapy 2017 9:64

    Published on: 17 August 2017

  20. Research

    Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

    Neuropsychological testing is considered crucial for differential diagnosis of Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD). In-depth neuropsychological assessment revealed ...

    Sophia Reul, Hubertus Lohmann, Heinz Wiendl, Thomas Duning and Andreas Johnen

    Alzheimer's Research & Therapy 2017 9:61

    Published on: 9 August 2017

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