Skip to main content

Articles

Page 1 of 33

  1. Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the pre...

    Authors: Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi and Gábor Csukly
    Citation: Alzheimer's Research & Therapy 2024 16:81
  2. In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discha...

    Authors: Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B. Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar and Kristian Steen Frederiksen
    Citation: Alzheimer's Research & Therapy 2024 16:80
  3. The hypothesis of decreased neural inhibition in dementia has been sparsely studied in functional magnetic resonance imaging (fMRI) data across patients with different dementia subtypes, and the role of social...

    Authors: Sebastian Moguilner, Rubén Herzog, Yonatan Sanz Perl, Vicente Medel, Josefina Cruzat, Carlos Coronel, Morten Kringelbach, Gustavo Deco, Agustín Ibáñez and Enzo Tagliazucchi
    Citation: Alzheimer's Research & Therapy 2024 16:79
  4. Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD). Numerous studies have asserted a close association between neuroinflammation ...

    Authors: Chang Liu, Alfredo Cárdenas-Rivera, Shayna Teitelbaum, Austin Birmingham, Mohammed Alfadhel and Mohammad A. Yaseen
    Citation: Alzheimer's Research & Therapy 2024 16:78
  5. Individuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A + T +), display a rapid cognitive decline and elevated disease progression risk. However, limite...

    Authors: Motonobu Fujishima, Yohei Kawasaki, Toshiharu Mitsuhashi and Hiroshi Matsuda
    Citation: Alzheimer's Research & Therapy 2024 16:77
  6. Both memory clinic professionals and patients see value in digital tools, yet these hardly find their way to clinical practice. We explored the usability of a digital tool to support the diagnostic work-up in ...

    Authors: Aniek M. van Gils, Hanneke F. M. Rhodius-Meester, Dédé Handgraaf, Heleen M. A. Hendriksen, Astrid van Strien, Niki Schoonenboom, Annemieke Schipper, Mariska Kleijer, Annemiek Griffioen, Majon Muller, Antti Tolonen, Jyrki Lötjönen, Wiesje M. van der Flier and Leonie N. C. Visser
    Citation: Alzheimer's Research & Therapy 2024 16:75
  7. Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes of intracerebral hemorrhage (ICH) and dementia in the elderly, remains unclea...

    Authors: Kanishk Kaushik, Anna M. de Kort, Rosemarie van Dort, Reinier G.J. van der Zwet, Bob Siegerink, Sabine Voigt, Erik W. van Zwet, Maaike C. van der Plas, Emma A. Koemans, Ingeborg Rasing, Roy P.C. Kessels, Huub A.M. Middelkoop, Floris H.B.M. Schreuder, Catharina J.M. Klijn, Marcel M. Verbeek, Gisela M. Terwindt…
    Citation: Alzheimer's Research & Therapy 2024 16:74
  8. Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI can support the clinical profile. Visual rating scales are a simple and reliable tool to assess b...

    Authors: Neus Falgàs, Luca Sacchi, Tiziana Carandini, Nuria Montagut, Giorgio Conte, Fabio Triulzi, Daniela Galimberti, Andrea Arighi, Raquel Sanchez-Valle and Giorgio Giulio Fumagalli
    Citation: Alzheimer's Research & Therapy 2024 16:73
  9. Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in sporadic behavioral variant frontotemporal dementia (bvFTD) remains un...

    Authors: Min Chu, Deming Jiang, Haitian Nan, Lulu Wen, Li Liu, Miao Qu and Liyong Wu
    Citation: Alzheimer's Research & Therapy 2024 16:72
  10. The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’...

    Authors: Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe and Ian F. Harrison
    Citation: Alzheimer's Research & Therapy 2024 16:71
  11. Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studi...

    Authors: Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane and Malcolm A. Leissring
    Citation: Alzheimer's Research & Therapy 2024 16:70
  12. Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the asso...

    Authors: Qingze Zeng, Yanbo Wang, Shuyue Wang, Xiao Luo, Kaicheng Li, Xiaopei Xu, Xiaocao Liu, Luwei Hong, Jixuan Li, Zheyu Li, Xinyi Zhang, Siyan Zhong, Zhirong Liu, Peiyu Huang, Yanxing Chen and Minming Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:69
  13. Mounting data suggests that herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of AD, possibly instigating amyloid-beta (Aβ) accumulation decades before the onset of clinical symptoms. However...

    Authors: Jose L. Cantero, Mercedes Atienza, Isabel Sastre and María Jesús Bullido
    Citation: Alzheimer's Research & Therapy 2024 16:68
  14. White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial h...

    Authors: Dario Bachmann, Bettina von Rickenbach, Andreas Buchmann, Martin Hüllner, Isabelle Zuber, Sandro Studer, Antje Saake, Katrin Rauen, Esmeralda Gruber, Roger M. Nitsch, Christoph Hock, Valerie Treyer and Anton Gietl
    Citation: Alzheimer's Research & Therapy 2024 16:67
  15. Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This h...

    Authors: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti…
    Citation: Alzheimer's Research & Therapy 2024 16:66
  16. It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adult...

    Authors: Shan Yin, Pei-Yang Gao, Ya-Nan Ou, Yan Fu, Ying Liu, Zuo-Teng Wang, Bao-Lin Han and Lan Tan
    Citation: Alzheimer's Research & Therapy 2024 16:65
  17. Posterior cortical atrophy (PCA) is a form of dementia that frequently displays significant visual dysfunction and relatively preserved cognitive and executive functions, thus hindering early diagnosis and tre...

    Authors: Yan Sun, Lumi Zhang, Hui Ye, Lumin Leng, Yi Chen, Yujie Su, Peifang Ren, Hong Lu and Guoping Peng
    Citation: Alzheimer's Research & Therapy 2024 16:64
  18. Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing cognitive abilities. While neuroimaging studies have revealed functional abnormalities in AD, how these relate to aberrant ...

    Authors: Parul Verma, Kamalini Ranasinghe, Janani Prasad, Chang Cai, Xihe Xie, Hannah Lerner, Danielle Mizuiri, Bruce Miller, Katherine Rankin, Keith Vossel, Steven W. Cheung, Srikantan S. Nagarajan and Ashish Raj
    Citation: Alzheimer's Research & Therapy 2024 16:62
  19. Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural...

    Authors: Ida Arvidsson, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Nicholas Cullen, Shorena Janelidze, Pontus Tideman, Anders Heyden, Karl Åström, Oskar Hansson and Niklas Mattsson-Carlgren
    Citation: Alzheimer's Research & Therapy 2024 16:61
  20. Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer’s disease (AD). However, the identification of effective FC biomarkers remains challenging....

    Authors: Ying Zhang, Le Xue, Shuoyan Zhang, Jiacheng Yang, Qi Zhang, Min Wang, Luyao Wang, Mingkai Zhang, Jiehui Jiang and Yunxia Li
    Citation: Alzheimer's Research & Therapy 2024 16:60
  21. We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians’ perception of those treatment needs, differ according t...

    Authors: Manabu Ikeda, Shunji Toya, Yuta Manabe, Hajime Yamakage and Mamoru Hashimoto
    Citation: Alzheimer's Research & Therapy 2024 16:59
  22. Cardiovascular health has been associated with dementia onset, but little is known about the variation of such association by sex and age considering dementia subtypes. We assessed the role of sex and age in t...

    Authors: Anna Ponjoan, Jordi Blanch, Ester Fages-Masmiquel, Ruth Martí-Lluch, Lia Alves-Cabratosa, María del Mar Garcia-Gil, Gina Domínguez-Armengol, Francesc Ribas-Aulinas, Lluís Zacarías-Pons and Rafel Ramos
    Citation: Alzheimer's Research & Therapy 2024 16:58
  23. In this study, the risk of dementia in patients with a history of herpes simplex virus (HSV) or varicella zoster virus (VZV) infection was evaluated.

    Authors: Eunhae Shin, Sang Ah Chi, Tae-Young Chung, Hee Jin Kim, Kyunga Kim and Dong Hui Lim
    Citation: Alzheimer's Research & Therapy 2024 16:57
  24. Although abnormal accumulation of amyloid beta (Aβ) protein is thought to be the main cause of Alzheimer’s disease (AD), emerging evidence suggests a pivotal vascular contribution to AD. Aberrant amyloid β ind...

    Authors: Siqi Chen, Daji Guo, Yuanyuan Zhu, Songhua Xiao, Jiatian Xie, Zhan Zhang, Yu Hu, Jialin Huang, Xueying Ma, Zhiyuan Ning, Lin Cao, Jinping Cheng and Yamei Tang
    Citation: Alzheimer's Research & Therapy 2024 16:56
  25. Multimer detection system-oligomeric amyloid-β (MDS-OAβ) is a measure of plasma OAβ, which is associated with Alzheimer’s disease (AD) pathology. However, the relationship between MDS-OAβ and disease severity ...

    Authors: Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Philip Scheltens and Hyun Kook Lim
    Citation: Alzheimer's Research & Therapy 2024 16:55
  26. Due to the heterogeneity among patients with Mild Cognitive Impairment (MCI), it is critical to predict their risk of converting to Alzheimer’s disease (AD) early using routinely collected real-world data such...

    Authors: Qi Zhang, Ron Coury and Wenlong Tang
    Citation: Alzheimer's Research & Therapy 2024 16:54
  27. Studies have suggested that blood circulating phytosterols, plant-derived sterols analogous to cholesterol, were associated with blood lipid levels and the risk of Alzheimer’s disease (AD) and Parkinson’s dise...

    Authors: Xingzhi Guo, Jing Yu, Rui Wang, Ning Peng and Rui Li
    Citation: Alzheimer's Research & Therapy 2024 16:53
  28. The key to the prevention and treatment of Alzheimer’s disease (AD) is to be able to predict and diagnose AD at the preclinical or early stage, but the lack of a preclinical model of AD is the critical factor ...

    Authors: Xinxin Huang, Shanshan Huang, Fangyan Fu, Junzhen Song, Yuling Zhang and Feng Yue
    Citation: Alzheimer's Research & Therapy 2024 16:52
  29. LUMIPULSE G-automated immunoassays represent a widely used method for the quantification of Alzheimer’s disease (AD) biomarkers in the cerebrospinal fluid (CSF). Less invasive blood-based markers confer a prom...

    Authors: Anuschka Silva-Spínola, Maria João Leitão, Alicia Nadal, Nathalie Le Bastard, Isabel Santana and Inês Baldeiras
    Citation: Alzheimer's Research & Therapy 2024 16:51
  30. Growing evidence suggests that not only cerebrovascular disease but also Alzheimer’s disease (AD) pathological process itself cause cerebral white matter degeneration, resulting in white matter hyperintensitie...

    Authors: Woo-Jin Cha, Dahyun Yi, Hyejin Ahn, Min Soo Byun, Yoon Young Chang, Jung-Min Choi, Kyungtae Kim, Hyeji Choi, Gijung Jung, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim and Dong Young Lee
    Citation: Alzheimer's Research & Therapy 2024 16:50
  31. Primary progressive aphasia (PPA) diagnostic criteria underestimate the complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms partially overlap, and mixed clinical presentation (...

    Authors: Gaia Chiara Santi, Francesca Conca, Valentina Esposito, Cristina Polito, Silvia Paola Caminiti, Cecilia Boccalini, Carmen Morinelli, Valentina Berti, Salvatore Mazzeo, Valentina Bessi, Alessandra Marcone, Sandro Iannaccone, Se-Kang Kim, Sandro Sorbi, Daniela Perani, Stefano F. Cappa…
    Citation: Alzheimer's Research & Therapy 2024 16:49
  32. The clinical meaningfulness of the effects of recently approved disease-modifying treatments (DMT) in Alzheimer’s disease is under debate. Available evidence is limited to short-term effects on clinical rating...

    Authors: Linus Jönsson, Milana Ivkovic, Alireza Atri, Ron Handels, Anders Gustavsson, Julie Hviid Hahn-Pedersen, Teresa León, Mathias Lilja, Jens Gundgaard and Lars Lau Raket
    Citation: Alzheimer's Research & Therapy 2024 16:48
  33. Authors: Rong Jiang, Xue-Fei Wu, Bin Wang, Rong-Xiao Guan, Lang-Man Lv, Ai-Ping Li, Lei Lei, Ye Ma, Na Li, Qi-Fa Li, Quan-Hong Ma, Jie Zhao and Shao Li
    Citation: Alzheimer's Research & Therapy 2024 16:47

    The original article was published in Alzheimer's Research & Therapy 2020 12:47

  34. Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenoty...

    Authors: Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya and Takeshi Ikeuchi
    Citation: Alzheimer's Research & Therapy 2024 16:45
  35. GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evalua...

    Authors: Mikel Tainta, Mirian Ecay-Torres, Maria de Arriba, Myriam Barandiaran, Ane Otaegui-Arrazola, Ane Iriondo, Maite Garcia-Sebastian, Ainara Estanga, Jon Saldias, Montserrat Clerigue, Alazne Gabilondo, Naia Ros, Justo Mugica, Aitziber Barandiaran, Francesca Mangialasche, Miia Kivipelto…
    Citation: Alzheimer's Research & Therapy 2024 16:44
  36. Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common pathogenesis for dementia. We hypothesize...

    Authors: Hui Hong, Luwei Hong, Xiao Luo, Qingze Zeng, Kaicheng Li, Shuyue Wang, Yeerfan Jiaerken, Ruiting Zhang, Xinfeng Yu, Yao Zhang, Cui Lei, Zhirong Liu, Yanxing Chen, Peiyu Huang and Minming Zhang
    Citation: Alzheimer's Research & Therapy 2024 16:43
  37. Optical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated the association of macular vessel density (VD) in the superficial plexus ...

    Authors: Ainhoa García-Sánchez, Oscar Sotolongo-Grau, Juan Pablo Tartari, Ángela Sanabria, Ester Esteban - De Antonio, Alba Pérez-Cordón, Montserrat Alegret, Vanesa Pytel, Joan Martínez, Núria Aguilera, Itziar de Rojas, Amanda Cano, Pablo García-González, Raquel Puerta, Clàudia Olivé, Maria Capdevila…
    Citation: Alzheimer's Research & Therapy 2024 16:42
  38. The relationship between periodontitis and Alzheimer’s disease (AD) has attracted more attention recently, whereas profiles of subgingival microbiomes and gingival crevicular fluid (GCF) metabolic signatures i...

    Authors: Che Qiu, Wei Zhou, Hui Shen, Jintao Wang, Ran Tang, Tao Wang, Xinyi Xie, Bo Hong, Rujing Ren, Gang Wang and Zhongchen Song
    Citation: Alzheimer's Research & Therapy 2024 16:41
  39. The use of structural and perfusion brain imaging in combination with behavioural information in the prediction of cognitive syndromes using a data-driven approach remains to be explored. Here, we thus examine...

    Authors: Ashwati Vipin, Bernett Teck Kwong Lee, Dilip Kumar, See Ann Soo, Yi Jin Leow, Smriti Ghildiyal, Faith Phemie Hui En Lee, Saima Hilal and Nagaendran Kandiah
    Citation: Alzheimer's Research & Therapy 2024 16:40
  40. Authors: Fernanda Schäfer Hackenhaar, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman and Sara Pudas
    Citation: Alzheimer's Research & Therapy 2024 16:39

    The original article was published in Alzheimer's Research & Therapy 2021 13:130

  41. Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer’s disease (AD). I...

    Authors: María Eugenia Sáez, Ainhoa García-Sánchez, Itziar de Rojas, Emilio Alarcón-Martín, Joan Martínez, Amanda Cano, Pablo García-González, Raquel Puerta, Clàudia Olivé, Maria Capdevila, Fernando García-Gutiérrez, Miguel Castilla-Martí, Luis Castilla-Martí, Ana Espinosa, Montserrat Alegret, Mario Ricciardi…
    Citation: Alzheimer's Research & Therapy 2024 16:38
  42. CLARITY-AD is an 18-month, double-blinded, placebo-controlled, phase 3 trial which examined the safety and efficacy of the anti-amyloid agent, lecanemab, in mild cognitive impairment and mild dementia due to A...

    Authors: Rawan Tarawneh and Vernon S. Pankratz
    Citation: Alzheimer's Research & Therapy 2024 16:37
  43. Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments...

    Authors: Pierre N. Tariot, Mercè Boada, Krista L. Lanctôt, Julie Hahn-Pedersen, Firas Dabbous, Sariya Udayachalerm, Lars Lau Raket, Yuliya Halchenko, Wojciech Michalak, Wendy Weidner and Jeffrey Cummings
    Citation: Alzheimer's Research & Therapy 2024 16:36
  44. Sleep-wake regulating circuits are affected during prodromal stages in the pathological progression of both Alzheimer’s disease (AD) and Parkinson’s disease (PD), and this disturbance can be measured passively...

    Authors: Joseph R. Winer, Renske Lok, Lara Weed, Zihuai He, Kathleen L. Poston, Elizabeth C. Mormino and Jamie M. Zeitzer
    Citation: Alzheimer's Research & Therapy 2024 16:35
  45. Lack of early molecular biomarkers in sporadic behavioral variants of frontotemporal dementia (bvFTD) and its clinical overlap with primary psychiatric disorders (PPD) hampers its diagnostic distinction. Synap...

    Authors: Shreyasee Das, Marie-Paule E. van Engelen, Julie Goossens, Dirk Jacobs, Bram Bongers, Jay L. P. Fieldhouse, Yolande A. L. Pijnenburg, Charlotte E. Teunissen, Eugeen Vanmechelen and Inge M. W. Verberk
    Citation: Alzheimer's Research & Therapy 2024 16:34
  46. Authors: Lindsey I. Sinclair, Asher Mohr, Mizuki Morisaki, Martin Edmondson, Selina Chan, A. Bone‑Connaughton, Gustavo Turecki and Seth Love
    Citation: Alzheimer's Research & Therapy 2024 16:33

    The original article was published in Alzheimer's Research & Therapy 2023 15:153

  47. The blood-based biomarkers are approaching the clinical practice of Alzheimer’s disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to ch...

    Authors: Jie Wu, Zhenxu Xiao, Mengjing Wang, Wanqing Wu, Xiaoxi Ma, Xiaoniu Liang, Li Zheng, Saineng Ding, Jianfeng Luo, Yang Cao, Zhen Hong, Jing Chen, Qianhua Zhao and Ding Ding
    Citation: Alzheimer's Research & Therapy 2024 16:32