O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, Rudow G, Iacono D, Riudavets MA, Driscoll I, Price DL, Martin LJ, Troncoso JC: Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). J Alzheimers Dis. 2009, 18: 665-675.
PubMed Central
PubMed
Google Scholar
Price JL, McKeel DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC: Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009, 30: 1026-1036. 10.1016/j.neurobiolaging.2009.04.002.
Article
PubMed Central
PubMed
Google Scholar
Aizenstein HJ, Nebes RD, Saxton JA, Price JC, Mathis CA, Tsopelas ND, Ziolko SK, James JA, Snitz BE, Houck PR, Bi W, Cohen AD, Lopresti BJ, DeKosky ST, Halligan EM, Klunk WE: Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008, 65: 1509-1517. 10.1001/archneur.65.11.1509.
Article
PubMed Central
PubMed
Google Scholar
Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA, Price JC, Reiman EM, Skovronsky D, Koeppe RA: The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core. Alzheimers Dement. 2010, 6: 221-229. 10.1016/j.jalz.2010.03.003.
Article
PubMed Central
PubMed
Google Scholar
Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC: [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006, 67: 446-452. 10.1212/01.wnl.0000228230.26044.a4.
Article
CAS
PubMed
Google Scholar
Resnick SM, Sojkova J, Zhou Y, An Y, Ye W, Holt DP, Dannals RF, Mathis CA, Klunk WE, Ferrucci L, Kraut MA, Wong DF: Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology. 2010, 74: 807-815. 10.1212/WNL.0b013e3181d3e3e9.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rowe CC, Ellis KA, Rimajova M, Bourgeat P, Pike KE, Jones G, Fripp J, Tochon-Danguy H, Morandeau L, O'Keefe G, Price R, Raniga P, Robins P, Acosta O, Lenzo N, Szoeke C, Salvado O, Head R, Martins R, Masters CL, Ames D, Villemagne VL: Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiol Aging. 2010, 31: 1275-1283. 10.1016/j.neurobiolaging.2010.04.007.
Article
PubMed
Google Scholar
Hyman BT: The neuropathological diagnosis of Alzheimer's disease: clinical-pathological studies. Neurobiol Aging. 1997, 18 (4 Suppl): S27-32. 10.1016/S0197-4580(97)00066-3.
Article
CAS
PubMed
Google Scholar
Morris JC, Storandt M, McKeel DW, Rubin EH, Price JL, Grant EA, Berg L: Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology. 1996, 46: 707-719.
Article
CAS
PubMed
Google Scholar
Morris JC: Mild cognitive impairment and preclinical Alzheimer's disease. Geriatrics. 2005, 9-14. Suppl
Driscoll I, Resnick SM, Troncoso JC, An Y, O'Brien R, Zonderman AB: Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. Ann Neurol. 2006, 60: 688-695. 10.1002/ana.21031.
Article
PubMed
Google Scholar
Galvin JE, Powlishta KK, Wilkins K, McKeel DW, Xiong C, Grant E, Storandt M, Morris JC: Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Arch Neurol. 2005, 62: 758-765. 10.1001/archneur.62.5.758.
Article
PubMed
Google Scholar
Petersen RC, Morris JC: Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol. 2005, 62: 1160-1163. 10.1001/archneur.62.7.1160. discussion 1167
Article
PubMed
Google Scholar
Sojkova J, Resnick SM: In vivo human amyloid imaging. Curr Alzheimer Res. 2011,
Google Scholar
Klunk WE, Mathis CA: Amyloid imaging and (what is normal?) aging. Imaging the Aging Brain. Edited by: Jagust WDE. 2009, Oxford, USA: Oxford University Press
Google Scholar
Jack CR, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, Shiung MM, Gunter JL, Boeve BF, Kemp BJ, Weiner M, Petersen RC, Alzheimer's Disease Neuroimaging Initiative: Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 2009, 132: 1355-1365. 10.1093/brain/awp062.
Article
PubMed Central
PubMed
Google Scholar
Vandenberghe R, Van Laere K, Ivanoiu A, Salmon E, Bastin C, Triau E, Hasselbalch S, Law I, Andersen A, Korner A, Minthon L, Garraux G, Nelissen N, Bormans G, Buckley C, Owenius R, Thurfjell L, Farrar G, Brooks DJ: (18) F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial. Ann Neurol. 2010, 68: 319-329. 10.1002/ana.22068.
Article
PubMed
Google Scholar
Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med. 2010, 51: 913-920. 10.2967/jnumed.109.069088.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rowe CC, Ackerman U, Browne W, Mulligan R, Pike KL, O'Keefe G, Tochon-Danguy H, Chan G, Berlangieri SU, Jones G, Dickinson-Rowe KL, Kung HP, Zhang W, Kung MP, Skovronsky D, Dyrks T, Holl G, Krause S, Friebe M, Lehman L, Lindemann S, Dinkelborg LM, Masters CL, Villemagne VL: Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol. 2008, 7: 129-135. 10.1016/S1474-4422(08)70001-2.
Article
CAS
PubMed
Google Scholar
Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR: PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006, 355: 2652-2663. 10.1056/NEJMoa054625.
Article
CAS
PubMed
Google Scholar
Tolboom N, Yaqub M, van der Flier WM, Boellaard R, Luurtsema G, Windhorst AD, Barkhof F, Scheltens P, Lammertsma AA, van Berckel BN: Detection of Alzheimer pathology In vivo using both 11C-PIB and 18F-FDDNP PET. J Nucl Med. 2009, 50: 191-197. 10.2967/jnumed.108.056499.
Article
PubMed
Google Scholar
Shin J, Lee SY, Kim SJ, Kim SH, Cho SJ, Kim YB: Voxel-based analysis of Alzheimer's disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG. Neuroimage. 2010, 52: 488-496. 10.1016/j.neuroimage.2010.04.013.
Article
PubMed
Google Scholar
Forsberg A, Engler H, Almkvist O, Blomquist G, Hagman G, Wall A, Ringheim A, Langstrom B, Nordberg A: PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging. 2008, 29: 1456-1465. 10.1016/j.neurobiolaging.2007.03.029.
Article
CAS
PubMed
Google Scholar
Okello A, Koivunen J, Edison P, Archer HA, Turkheimer FE, Någren K, Bullock R, Walker Z, Kennedy A, Fox NC, Rossor MN, Rinne JO, Brooks DJ: Conversion of amyloid positive and negative MCI to AD over 3 years. An 11C-PIB PET study. Neurology. 2009, 73: 754-760. 10.1212/WNL.0b013e3181b23564.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wolk DA, Price JC, Saxton JA, Snitz BE, James JA, Lopez OL, Aizenstein HJ, Cohen AD, Weissfeld LA, Mathis CA, Klunk WE, De-Kosky ST: Amyloid imaging in mild cognitive impairment subtypes. Ann Neurol. 2009, 65: 557-568. 10.1002/ana.21598.
Article
PubMed Central
PubMed
Google Scholar
Li Y, Rinne JO, Mosconi L, Pirraglia E, Rusinek H, DeSanti S, Kemppainen N, Någren K, Kim BC, Tsui W, de Leon MJ: Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2008, 35: 2169-2181. 10.1007/s00259-008-0833-y.
Article
PubMed Central
PubMed
Google Scholar
Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA: Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab. 2005, 25: 1528-1547. 10.1038/sj.jcbfm.9600146.
Article
CAS
PubMed
Google Scholar
Rowe CC, Ng S, Ackermann U, Gong SJ, Pike K, Savage G, Cowie TF, Dickinson KL, Maruff P, Darby D, Smith C, Woodward M, Merory J, Tochon-Danguy H, O'Keefe G, Klunk WE, Mathis CA, Price JC, Masters CL, Villemagne VL: Imaging beta-amyloid burden in aging and dementia. Neurology. 2007, 68: 1718-1725. 10.1212/01.wnl.0000261919.22630.ea.
Article
CAS
PubMed
Google Scholar
Lowe VJ, Kemp BJ, Jack CR, Senjem M, Weigand S, Shiung M, Smith G, Knopman D, Boeve B, Mullan B, Petersen RC: Comparison of 18F-FDG and PiB PET in cognitive impairment. J Nucl Med. 2009, 50: 878-886. 10.2967/jnumed.108.058529.
Article
PubMed Central
PubMed
Google Scholar
Rosen RF, Ciliax BJ, Wingo TS, Gearing M, Dooyema J, Lah JJ, Ghiso JA, Levine H, Walker LC: Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol. 2010, 119: 221-233. 10.1007/s00401-009-0583-3.
Article
PubMed Central
CAS
PubMed
Google Scholar
Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA: APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol. 2010, 67: 122-131. 10.1002/ana.21843.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stern Y: What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc. 2002, 8: 448-460. 10.1017/S1355617702813248.
Article
PubMed
Google Scholar
Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA: Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol. 2010, 67: 353-364. 10.1001/archneurol.2010.19.
PubMed Central
PubMed
Google Scholar
Chételat G, Villemagne VL, Pike KE, Baron JC, Bourgeat P, Jones G, Faux NG, Ellis KA, Salvado O, Szoeke C, Martins RN, Ames D, Masters CL, Rowe CC, Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group: Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain. 2010, 133: 3349-3358.
Article
PubMed
Google Scholar
Pike KE, Savage G, Villemagne VL, Ng S, Moss SA, Maruff P, Mathis CA, Klunk WE, Masters CL, Rowe CC: Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 2007, 130: 2837-2844. 10.1093/brain/awm238.
Article
PubMed
Google Scholar
Tolboom N, van der Flier WM, Yaqub M, Koene T, Boellaard R, Windhorst AD, Scheltens P, Lammertsma AA, van Berckel BN: Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment. Neurology. 2009, 73: 2079-2085. 10.1212/WNL.0b013e3181c679cc.
Article
CAS
PubMed
Google Scholar
Forsberg A, Almkvist O, Engler H, Wall A, Langstrom B, Nordberg A: High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters. Curr Alzheimer Res. 2010, 7: 56-66. 10.2174/156720510790274446.
Article
CAS
PubMed
Google Scholar
Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant EA, Morris JC: Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. Arch Neurol. 2008, 65: 1467-1471. 10.1001/archneur.65.11.1467.
Article
PubMed Central
PubMed
Google Scholar
Braskie MN, Klunder AD, Hayashi KM, Protas H, Kepe V, Miller KJ, Huang SC, Barrio JR, Ercoli LM, Siddarth P, Satyamurthy N, Liu J, Toga AW, Bookheimer SY, Small GW, Thompson PM: Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging. 2010, 31: 1669-1678. 10.1016/j.neurobiolaging.2008.09.012.
Article
PubMed Central
PubMed
Google Scholar
Furst AJ, Rabinovici GD, Rostomian AH, Steed T, Alkalay A, Racine C, Miller BL, Jagust WJ: Cognition, glucose metabolism and amyloid burden in Alzheimer's disease. Neurobiol Aging. 2010,
Google Scholar
Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ: Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009, 132: 1310-1323. 10.1093/brain/awn320.
Article
PubMed Central
CAS
PubMed
Google Scholar
Storandt M, Mintun MA, Head D, Morris JC: Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol. 2009, 66: 1476-1481. 10.1001/archneurol.2009.272.
Article
PubMed Central
PubMed
Google Scholar
Villemagne VL, Pike KE, Darby D, Maruff P, Savage G, Ng S, Ackermann U, Cowie TF, Currie J, Chan SG, Jones G, Tochon-Danguy H, O'Keefe G, Masters CL, Rowe CC: Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia. 2008, 46: 1688-1697. 10.1016/j.neuropsychologia.2008.02.008.
Article
CAS
PubMed
Google Scholar
Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka SK, Jauhianen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H: PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment. Dement Geriatr Cogn Disord. 2008, 26: 378-383. 10.1159/000163927.
Article
CAS
PubMed
Google Scholar
Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA: Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch Neurol. 2009, 66: 1469-1475. 10.1001/archneurol.2009.269.
Article
PubMed Central
PubMed
Google Scholar
Johnson KA, Gregas M, Becker JA, Kinnecom C, Salat DH, Moran EK, Smith EE, Rosand J, Rentz DM, Klunk WE, Mathis CA, Price JC, Dekosky ST, Fischman AJ, Greenberg SM: Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol. 2007, 62: 229-234. 10.1002/ana.21164.
Article
PubMed
Google Scholar
Davatzikos C, Xu F, An Y, Fan Y, Resnick SM: Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain. 2009, 132: 2026-2035. 10.1093/brain/awp091.
Article
PubMed Central
PubMed
Google Scholar
Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA, Blennow K, Barakos J, Okello AA, Rodriguez Martinez de Liano S, Liu E, Koller M, Gregg KM, Schenk D, Black R, Grundman M: 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol. 2010, 9: 363-372. 10.1016/S1474-4422(10)70043-0.
Article
CAS
PubMed
Google Scholar
Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010, 9: 119-128. 10.1016/S1474-4422(09)70299-6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Iacono D, O'Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, An Y, West MJ, Crain B, Troncoso JC: Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol. 2008, 67: 578-589. 10.1097/NEN.0b013e3181772794.
Article
PubMed Central
PubMed
Google Scholar
Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC: Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiol Aging. 2007, 28: 1484-1492. 10.1016/j.neurobiolaging.2007.05.005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Aisen PS: Predictors of progression in the ADNI-MCI cohort. Alzheimers Dementia. 2010, 6: S63-10.1016/j.jalz.2010.05.180.
Article
Google Scholar
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM: Inverse relation between In vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006, 59: 512-519. 10.1002/ana.20730.
Article
CAS
PubMed
Google Scholar
Grimmer T, Henriksen G, Wester HJ, Forstl H, Klunk WE, Mathis CA, Kurz A, Drzezga A: Clinical severity of Alzheimer's disease is associated with PIB uptake in PET. Neurobiol Aging. 2009, 30: 1902-1909. 10.1016/j.neurobiolaging.2008.01.016.
Article
CAS
PubMed
Google Scholar