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Table 2 Associations between β-amyloid burden and cognition in cognitively normal individuals

From: Amyloid imaging and memory change for prediction of cognitive impairment

Study Year Radiotracer Samplea Number of subjectsa Mean age (SD) Method Associations between amyloid imaging and cognitive function
Cross-sectional measures of concurrent β-amyloid load and cognition
Rowe et al. [7] 2010 PiB CN 177 71.6 (7.4) SUVR No association with long delay verbal recall (CVLT) No difference in long delay verbal recall between those with high versus low PiB binding
Rentz et al. [33] 2010 PiB CN 66 73.9 (8.1) DVR No main effect of precuneus PiB on cognitive function Higher precuneus PiB associated with lower cued (but not free recall) and canonical variate score in CN individuals with low but not high cognitive reserve measured by AMNART
Storandt et al. [42] 2009 PiB CN 135 PiB- 74.3 (6.2) Pib+ 75.4 (6.3) BP No association with global, verbal, spatial, or working memory composites or individual cognitive measures
Braskie et al. [39] 2010 [18F]FDDNP CN 10 73 (10.4) DVR Higher [18F]FDDNP in right frontal and some parietal areas associated with lower composite cognitive score
Mormino et al. [41] 2009 PiB CNb 20 72.3 (6.0) SUVR, DVR Higher PiB associated with lower episodic memory composite score (P < 0.01)
Mormino et al. [41] 2009 PiB CNc 17 78.5 (5.4) SUVR, DVR No associations with episodic memory composite score
Rowe et al. [28] 2007 PiB CN 27 72.6 (6.9) DVR No difference in cognitive performance between PiB-positive and PiB-negative
Pike et al. [35] 2007 PiB CN 32 71.7 (6.6) SUVR Higher PiB associated with lower episodic memory composite score (r = -0.38, P < 0.05) PiB-positive compared with PiB-negative had lower episodic memory composite score (P < 0.05)
Cross-sectional measures of β-amyloid load and longitudinal measures of cognition
Resnick et al. [6] 2010 PiB CN 57 (6 CDR = 0.5) 78.8 (6.2) DVR Higher PiB associated with greater decline in immediate and delayed verbal recall and MMSE (all P ≤ 0.01) but not visual memory Associations most pronounced for frontal and lateral temporal cortex, as well as putamen
Storandt et al. [42] 2009 PiB CN 135 PiB- 74.3 (6.2) Pib+ 75.4 (6.3) BP Higher PiB associated with greater decline in working memory and visuospatial ability
Villemagne et al. [43] 2008 PiB Stable (S), declining (D) 24 S, 10 D S 71.7 (6.7) D 75.5 (4.4) SUVR Higher PiB associated with greater decline in word-list recall (r = -0.78) in decliners only
  1. aIn some cases a study subsample. bBerkeley Aging Study. cAlzheimer's Disease Neuroimaging Initiative (ADNI) cohort. AMNART, American National Adult Reading Test; BP, binding potential; CDR, Clinical Dementia Rating scale; CN, cognitively normal; CVLT, California Verbal Learning Test; DVR, distribution volume ratio; MMSE, Mini-Mental State Examination; PiB, [11C]Pittsburgh Compound-B; RAVLT, Rey Auditory Verbal Learning Test; SD, standard deviation; SUVR, standard uptake value ratio.