Table 1 Cross-sectional associations between PiB-assessed β-amyloid burden and cognition in AD and MCI

Furst et al. [40]

No association with MMSE or CDR-SOB

Forsberg et al. [37]

Higher PiB in bilateral frontal cortices and posterior cingulate gyrus weakly associated with lower verbal memory (RAVLT) in AD alone

Grimmer et al. [54]

Higher PiB in bilateral frontal and anterior cingulate cortex, and lentiform nucleus (P ≤ 0.05) associated with higher CDR-SOB

Rowe et al. [28]

No significant association with long delay verbal recall (CVLT) or MMSE

Pike et al. [35]

No association with composite score of episodic memory

Rowe et al. [7]

Higher PiB shows trend with lower long delay verbal recall (CVLT; r = -0.24, P = 0.07)

Wolk et al. [25]

PiB-positive aMCI have lower verbal delayed recall than PiB-negative aMCI (P < 0.01) but PiB-positive were also substantially older

Lowe et al. [29]

No significant memory difference between aMCI-negative and aMCI-positive (but aMCI-negative substantially older)

Mormino et al. [41]

Higher PiB associated with lower verbal delayed recall (RAVLT; P = 0.05)

Forsberg et al. [23]

Higher PiB in posterior cingulate, frontal, and temporal cortex (P ≤ 0.05) associated with lower composite score of episodic memory

Pike et al. [35]

Higher PiB associated with lower composite score of episodic memory (r = -0.6, P < 0.001) and remains significant when limited to aMCI