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Table 1 Cross-sectional associations between PiB-assessed β-amyloid burden and cognition in AD and MCI

From: Amyloid imaging and memory change for prediction of cognitive impairment

Study Year Samplea Number of
Mean age (SD) Method Associations between PiB retention and cognitive function
Furst et al. [40] 2010 AD 39 68.3 (10.5) DVR No association with MMSE or CDR-SOB
Forsberg et al. [37] 2010 AD 37 67.5 (9.2) SUVR Higher PiB in bilateral frontal cortices and posterior cingulate gyrus weakly associated with lower verbal memory (RAVLT) in AD alone
Grimmer et al. [54] 2009 AD with AD-typical FDG scan 32 66.9 (8.5) SUVR Higher PiB in bilateral frontal and anterior cingulate cortex, and lentiform nucleus (P ≤ 0.05) associated with higher CDR-SOB
Rowe et al. [28] 2007 AD 17 74.0 (11.3) DVR No significant association with long delay verbal recall (CVLT) or MMSE
Pike et al. [35] 2007 AD 31 74.8 (10.2) SUVR No association with composite score of episodic memory
Rowe et al. [7] 2010 MCI 57 75.5 (7.5) SUVR Higher PiB shows trend with lower long delay verbal recall (CVLT; r = -0.24, P = 0.07)
Wolk et al. [25] 2009 MCI 26 70.2 (8.8) DVR PiB-positive aMCI have lower verbal delayed recall than PiB-negative aMCI (P < 0.01) but PiB-positive were also substantially older
Lowe et al. [29] 2009 MCI 23 82 (aMCI-), 73 (aMCI+) SUVR No significant memory difference between aMCI-negative and aMCI-positive (but aMCI-negative substantially older)
Mormino et al. [41] 2009 PiB+ MCI 39 75.0 (7.9) DVR Higher PiB associated with lower verbal delayed recall (RAVLT; P = 0.05)
Forsberg et al. [23] 2008 MCI 21 63.3 (7.8) SUVR Higher PiB in posterior cingulate, frontal, and temporal cortex (P ≤ 0.05) associated with lower composite score of episodic memory
Pike et al. [35] 2007 MCI 33 70.7(9.6) SUVR Higher PiB associated with lower composite score of episodic memory (r = -0.6, P < 0.001) and remains significant when limited to aMCI
  1. aIn some cases a study subsample. AD, Alzheimer's disease; aMCI, amnestic MCI; CDR-SOB, Clinical Dementia Rating scale Sum of Boxes; CVLT, California Verbal Learning Test; DVR, distribution volume ratio; FDG, fluorodeoxyglucose; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; PiB, [11C]Pittsburgh Compound-B; RAVLT, Rey Auditory Verbal Learning Test; SD, standard deviation; SUVR, standard uptake value ratio.