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Table 3 Amyloid imaging and prediction of conversion to Alzheimer's disease

From: Amyloid imaging and memory change for prediction of cognitive impairment

Study Year Radiotracer Samplea Number of subjectsa Mean age (SD) Method Findings
Okello et al. [24] 2009 PiB MCI 31 69.4 (7.9) SUVR 82% PiB-positive MCI convert to AD compared to 7% of PiB-negative MCI 47% PiB-positive MCI who convert to AD within 1 year have higher PiB in anterior cingulate and frontal cortex (P < 0.05), APOE ε4 is associated with faster conversion rates in PiB-positive MCI (P < 0.05)
Wolk et al. [25] 2009 PiB MCI 26 (23 with follow-up) 70.2 (8.8) DVR 38% PiB-positive MCI but no PiB- convert to AD over 22 months
Morris et al. [45] 2009 PiB CN 159 71.5 (8.6) BP Higher PiB retention predicts progression from CDR 0 to MCI (hazard ratio = 2.74) and AD (hazard ratio = 4.85) over mean 2.4 years
Koivunen et al. [44] 2008 PiB aMCI 15 71.1 (7.2) SUVR, DVR Elevated PiB in six converters in posterior cingulate and frontal cortex as well as elevated neocortical score
Forsberg et al. [23] 2008 PiB MCI 21 63.3 (7.8) SUVR Higher PiB retention in frontal, parietal, and temporal cortices (P < 0.01) in MCI converters than CN individuals Higher PiB retention in posterior cingulate gyrus in MCI converters than MCI nonconverters (P < 0.01) No difference in PiB retention between MCI converters and AD
Small et al. [20] 2006 [18F]FDDNP AD, MCI, CN 4 MCI, 8 CN NA for this subset DVR Three disease progressors had increases in [18F]FDDNP between 5.5% to 11.2% compared to ≤3% in nine non-progressors
  1. aIn some cases a study subsample. AD, Alzheimer's disease; aMCI, amnestic MCI; APOE, Apolipoprotein E; BP, binding potential; CN, cognitively normal; DVR, distribution volume ratio; MCI, mild cognitive impairment; NA, not available; PiB, [11C]Pittsburgh Compound-B; SD, standard deviation; SUVR, standard uptake value ratio.