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  1. Research

    Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity

    Informal care is essential for many people with dementia (PwD), but it often results in a considerable burden for the caregiver. The perseverance time instrument integrates the aspect of perceived burden with ...

    Anke Richters, René J. F. Melis, N. Job van Exel, Marcel G. M. Olde Rikkert and Marjolein A. van der Marck

    Alzheimer's Research & Therapy 2017 9:26

    Published on: 4 April 2017

  2. Research

    Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

    18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to con...

    Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier and Pedro Rosa-Neto

    Alzheimer's Research & Therapy 2017 9:25

    Published on: 31 March 2017

  3. Research

    Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer’s disease

    The incidence of Alzheimer’s disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investig...

    Frances C. Quevenco, Maria G. Preti, Jiri M. G. van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J. Schreiner, Stefanie C. Steininger, Rafael Meyer, Irene B. Meier, Adam M. Brickman, Sandra E. Leh, Anton F. Gietl, Alfred Buck, Roger M. Nitsch, Klaas P. Pruessmann…

    Alzheimer's Research & Therapy 2017 9:24

    Published on: 31 March 2017

  4. Research

    DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

    The apolipoprotein E ɛ4 (APOE4) allele is the strongest genetic risk factor identified for developing Alzheimer’s disease (AD). Among brain lipids, alteration in the ω-3 polyunsaturated fatty acid docosahexaenoic...

    Hussein N. Yassine, Etienne Croteau, Varun Rawat, Joseph R. Hibbeln, Stanley I. Rapoport, Stephen C. Cunnane and John C. Umhau

    Alzheimer's Research & Therapy 2017 9:23

    Published on: 23 March 2017

  5. Research

    Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning

    Errorless learning (EL) is a method for optimizing learning, which uses feed-forward instructions in order to prevent people from making mistakes during the learning process. The majority of previous studies o...

    Sebastian Voigt-Radloff, Maartje M. E. de Werd, Rainer Leonhart, Danielle H. E. Boelen, Marcel G. M. Olde Rikkert, Klaus Fliessbach, Stefan Klöppel, Bernhard Heimbach, Andreas Fellgiebel, Richard Dodel, Gerhard W. Eschweiler, Lucrezia Hausner, Roy P. C. Kessels and Michael Hüll

    Alzheimer's Research & Therapy 2017 9:22

    Published on: 23 March 2017

  6. Research

    Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population

    Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer’s dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT...

    Thibault Mura, Marieta Baramova, Audrey Gabelle, Sylvaine Artero, Jean-François Dartigues, Hélène Amieva and Claudine Berr

    Alzheimer's Research & Therapy 2017 9:21

    Published on: 23 March 2017

  7. Research

    Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

    Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer’s disease (AD) biomarker because blood is an easily accessible bio-fluid, which can be collected routinely, and Aβ is one of the major hallmarks ...

    Jong-Chan Park, Sun-Ho Han, Hyun Jin Cho, Min Soo Byun, Dahyun Yi, Young Min Choe, Seokjo Kang, Eun Sun Jung, Su Jin Won, Eun Hye Kim, Yu Kyeong Kim, Dong Young Lee and Inhee Mook-Jung

    Alzheimer's Research & Therapy 2017 9:20

    Published on: 22 March 2017

  8. Research

    Cognitive profile in prodromal dementia with Lewy bodies

    Cortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spa...

    Jennifer Kemp, Nathalie Philippi, Clélie Phillipps, Catherine Demuynck, Timothée Albasser, Catherine Martin-Hunyadi, Catherine Schmidt-Mutter, Benjamin Cretin and Frédéric Blanc

    Alzheimer's Research & Therapy 2017 9:19

    Published on: 16 March 2017

  9. Research

    Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

    Alzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive functi...

    Raphael Hesse, Ludwig Lausser, Pauline Gummert, Florian Schmid, Anke Wahler, Cathrin Schnack, Katja S. Kroker, Markus Otto, Hayrettin Tumani, Hans A. Kestler, Holger Rosenbrock and Christine A. F. von Arnim

    Alzheimer's Research & Therapy 2017 9:17

    Published on: 9 March 2017

  10. Review

    Role of neuroinflammation in neurodegeneration: new insights

    Previously, the contribution of peripheral infection to cognitive decline was largely overlooked however, the past 15 years have established a key role for infectious pathogens in the progression of age-relate...

    Róisín M. McManus and Michael T. Heneka

    Alzheimer's Research & Therapy 2017 9:14

    Published on: 4 March 2017

  11. Research

    Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

    The number of people living with dementia is expected to exceed 130 million by 2050, which will have serious personal, social and economic implications. Employing successful intervention and treatment strategi...

    Shea J. Andrews, Ranmalee Eramudugolla, Jorge I. Velez, Nicolas Cherbuin, Simon Easteal and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:16

    Published on: 4 March 2017

  12. Research

    Evaluation of a research diagnostic algorithm for DSM-5 neurocognitive disorders in a population-based cohort of older adults

    There is little information on the application and impact of revised criteria for diagnosing dementia and mild cognitive impairment (MCI), now termed major and mild neurocognitive disorders (NCDs) in the DSM-5...

    Ranmalee Eramudugolla, Moyra E. Mortby, Perminder Sachdev, Chantal Meslin, Rajeev Kumar and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:15

    Published on: 4 March 2017

  13. Research

    Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

    Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer’s disease (AD). In this study, we investigated the association between retinal vascular and structural changes and c...

    S.Mojtaba Golzan, Kathryn Goozee, Dana Georgevsky, Alberto Avolio, Pratishtha Chatterjee, Kaikai Shen, Vivek Gupta, Roger Chung, Greg Savage, Carolyn F. Orr, Ralph N. Martins and Stuart L. Graham

    Alzheimer's Research & Therapy 2017 9:13

    Published on: 1 March 2017

  14. Research

    Proportion of dementia in Australia explained by common modifiable risk factors

    At present, dementia has no known cure. Interventions to delay onset and reduce prevalence of the disease are therefore focused on risk factor reduction. Previous population attributable risk estimates for wes...

    Kimberly Ashby-Mitchell, Richard Burns, Jonathan Shaw and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:11

    Published on: 17 February 2017

  15. Research

    The effects of different familial Alzheimer’s disease mutations on APP processing in vivo

    Disturbed amyloid precursor protein (APP) processing is considered to be central to the pathogenesis of Alzheimer’s disease (AD). The autosomal dominant form of the disease, familial AD (FAD), may serve as a m...

    Steinunn Thordardottir, Anne Kinhult Ståhlbom, Ove Almkvist, Håkan Thonberg, Maria Eriksdotter, Henrik Zetterberg, Kaj Blennow and Caroline Graff

    Alzheimer's Research & Therapy 2017 9:9

    Published on: 16 February 2017

  16. Research

    Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

    The pathophysiology of insulin resistance-induced hypertension and hyperlipidemia might entail differences in dementia risk in cases with hypertension and hyperlipidemia without prior diabetes mellitus (DM). T...

    Yen-Chun Fan, Jung-Lung Hsu, Hong-Yi Tung, Chia-Chi Chou and Chyi-Huey Bai

    Alzheimer's Research & Therapy 2017 9:7

    Published on: 6 February 2017

  17. Research

    Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

    During adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer’s disease (AD) pathology on cognitive impairment in later life....

    Domilė Tautvydaitė, Deepti Kukreja, Jean-Philippe Antonietti, Hugues Henry, Armin von Gunten and Julius Popp

    Alzheimer's Research & Therapy 2017 9:6

    Published on: 2 February 2017

  18. Research

    Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

    Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer’s disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affec...

    Henrietta M. Nielsen, Kewei Chen, Wendy Lee, Yinghua Chen, Robert J. Bauer III, Eric Reiman, Richard Caselli and Guojun Bu

    Alzheimer's Research & Therapy 2017 9:5

    Published on: 30 January 2017

  19. Research

    A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging

    Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs...

    Juan Li, Lucas S. Broster, Gregory A. Jicha, Nancy B. Munro, Frederick A. Schmitt, Erin Abner, Richard Kryscio, Charles D. Smith and Yang Jiang

    Alzheimer's Research & Therapy 2017 9:3

    Published on: 19 January 2017

  20. Research

    Diagnostic impact of [18F]flutemetamol PET in early-onset dementia

    Early-onset dementia patients often present with atypical clinical symptoms, hampering an accurate clinical diagnosis. The purpose of the present study was to assess the diagnostic impact of the amyloid-positr...

    Marissa D. Zwan, Femke H. Bouwman, Elles Konijnenberg, Wiesje M. van der Flier, Adriaan A. Lammertsma, Frans R. J. Verhey, Pauline Aalten, Bart N. M. van Berckel and Philip Scheltens

    Alzheimer's Research & Therapy 2017 9:2

    Published on: 17 January 2017

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