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Research
Informal care is essential for many people with dementia (PwD), but it often results in a considerable burden for the caregiver. The perseverance time instrument integrates the aspect of perceived burden with ...
Alzheimer's Research & Therapy 2017 9:26
Published on: 4 April 2017
Research
18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to con...
Alzheimer's Research & Therapy 2017 9:25
Published on: 31 March 2017
Research
The incidence of Alzheimer’s disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investig...
Alzheimer's Research & Therapy 2017 9:24
Published on: 31 March 2017
Research
The apolipoprotein E ɛ4 (APOE4) allele is the strongest genetic risk factor identified for developing Alzheimer’s disease (AD). Among brain lipids, alteration in the ω-3 polyunsaturated fatty acid docosahexaenoic...
Alzheimer's Research & Therapy 2017 9:23
Published on: 23 March 2017
Research
Errorless learning (EL) is a method for optimizing learning, which uses feed-forward instructions in order to prevent people from making mistakes during the learning process. The majority of previous studies o...
Alzheimer's Research & Therapy 2017 9:22
Published on: 23 March 2017
Research
Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer’s dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT...
Alzheimer's Research & Therapy 2017 9:21
Published on: 23 March 2017
Research
Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer’s disease (AD) biomarker because blood is an easily accessible bio-fluid, which can be collected routinely, and Aβ is one of the major hallmarks ...
Alzheimer's Research & Therapy 2017 9:20
Published on: 22 March 2017
Research
Accurate and timely diagnosis of Alzheimer’s disease (AD) is important for prompt initiation of treatment in patients with AD and to avoid inappropriate treatment of patients with false-positive diagnoses.
Alzheimer's Research & Therapy 2017 9:18
Published on: 16 March 2017
Research
Cortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spa...
Alzheimer's Research & Therapy 2017 9:19
Published on: 16 March 2017
Research
Alzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive functi...
Alzheimer's Research & Therapy 2017 9:17
Published on: 9 March 2017
Review
Previously, the contribution of peripheral infection to cognitive decline was largely overlooked however, the past 15 years have established a key role for infectious pathogens in the progression of age-relate...
Alzheimer's Research & Therapy 2017 9:14
Published on: 4 March 2017
Research
The number of people living with dementia is expected to exceed 130 million by 2050, which will have serious personal, social and economic implications. Employing successful intervention and treatment strategi...
Alzheimer's Research & Therapy 2017 9:16
Published on: 4 March 2017
Research
There is little information on the application and impact of revised criteria for diagnosing dementia and mild cognitive impairment (MCI), now termed major and mild neurocognitive disorders (NCDs) in the DSM-5...
Alzheimer's Research & Therapy 2017 9:15
Published on: 4 March 2017
Research
Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer’s disease (AD). In this study, we investigated the association between retinal vascular and structural changes and c...
Alzheimer's Research & Therapy 2017 9:13
Published on: 1 March 2017
Erratum
Alzheimer's Research & Therapy 2017 9:12
Published on: 27 February 2017
The original article was published in Alzheimer's Research & Therapy 2016 8:59
Research
At present, dementia has no known cure. Interventions to delay onset and reduce prevalence of the disease are therefore focused on risk factor reduction. Previous population attributable risk estimates for wes...
Alzheimer's Research & Therapy 2017 9:11
Published on: 17 February 2017
Research
Despite substantial research and development investment in Alzheimer’s disease (AD), effective therapeutics remain elusive. Significant emerging evidence has linked cholesterol, β-amyloid and AD, and several s...
Alzheimer's Research & Therapy 2017 9:10
Published on: 17 February 2017
Research
Disturbed amyloid precursor protein (APP) processing is considered to be central to the pathogenesis of Alzheimer’s disease (AD). The autosomal dominant form of the disease, familial AD (FAD), may serve as a m...
Alzheimer's Research & Therapy 2017 9:9
Published on: 16 February 2017
Research
We sought to define a cutoff for β-amyloid 1–42 in cerebrospinal fluid (CSF), a key marker for Alzheimer’s disease (AD), with data-driven Gaussian mixture modeling in a memory clinic population.
Alzheimer's Research & Therapy 2017 9:8
Published on: 14 February 2017
Research
The pathophysiology of insulin resistance-induced hypertension and hyperlipidemia might entail differences in dementia risk in cases with hypertension and hyperlipidemia without prior diabetes mellitus (DM). T...
Alzheimer's Research & Therapy 2017 9:7
Published on: 6 February 2017
Research
During adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer’s disease (AD) pathology on cognitive impairment in later life....
Alzheimer's Research & Therapy 2017 9:6
Published on: 2 February 2017
Research
Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer’s disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affec...
Alzheimer's Research & Therapy 2017 9:5
Published on: 30 January 2017
Research
Amyloid precursor protein (APP) is cleaved by β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) to produce β-amyloid (Aβ), a critical pathogenic peptide in Alzheimer’s disease (AD). Aβ generation can ...
Alzheimer's Research & Therapy 2017 9:4
Published on: 21 January 2017
Research
Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs...
Alzheimer's Research & Therapy 2017 9:3
Published on: 19 January 2017
Research
Early-onset dementia patients often present with atypical clinical symptoms, hampering an accurate clinical diagnosis. The purpose of the present study was to assess the diagnostic impact of the amyloid-positr...
Alzheimer's Research & Therapy 2017 9:2
Published on: 17 January 2017
