Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, et al. Alzheimer’s disease. Lancet. 2021;397(10284):1577–90.
Article
CAS
Google Scholar
Zhang F, Zhong RJ, Cheng C, Li S, Le WD. New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease. Acta Pharmacol Sin. 2021;42(9):1382–9.
Article
CAS
Google Scholar
Plog BA, Nedergaard M. The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol. 2018;13:379–94.
Article
CAS
Google Scholar
Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020;16(3):137–53.
Article
Google Scholar
Kwee RM, Kwee TC. Virchow-Robin spaces at MR imaging. Radiographics. 2007;27(4):1071–86.
Article
Google Scholar
Doubal FN, MacLullich AM, Ferguson KJ, Dennis MS, Wardlaw JM. Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease. Stroke. 2010;41(3):450–4.
Article
Google Scholar
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4(147):147ra11.
Article
Google Scholar
Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016–24.
Article
CAS
Google Scholar
Venkat P, Chopp M, Zacharek A, Cui C, Zhang L, Li Q, et al. White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies. Neurobiol Aging. 2017;50:96–106.
Shen T, Yue Y, Zhao S, Xie J, Chen Y, Tian J, et al. The role of brain perivascular space burden in early-stage Parkinson’s disease. NPJ Parkinsons Dis. 2021;7(1):12.
Article
CAS
Google Scholar
Li Y, Zhu Z, Chen J, Zhang M, Yang Y, Huang P. Dilated perivascular space in the midbrain may reflect dopamine neuronal degeneration in Parkinson’s disease. Front Aging Neurosci. 2020;12:161.
Article
Google Scholar
Donahue EK, Murdos A, Jakowec MW, Sheikh-Bahaei N, Toga AW, Petzinger GM, et al. Global and regional changes in perivascular space in idiopathic and familial Parkinson’s disease. Mov Disord. 2021;36(5):1126–36.
Article
CAS
Google Scholar
Chan ST, Mercaldo ND, Ravina B, Hersch SM, Rosas HD. Association of dilated perivascular spaces and disease severity in patients with Huntington disease. Neurology. 2021;96(6):e890–e4.
CAS
Google Scholar
Wang ML, Sun Z, Li WB, Zou QQ, Li PY, Wu X, et al. Enlarged perivascular spaces and white matter hyperintensities in patients with frontotemporal lobar degeneration syndromes. Front Aging Neurosci. 2022;14:923193.
Article
CAS
Google Scholar
Lyndon D, Davagnanam I, Wilson D, Jichi F, Merwick A, Bolsover F, et al. MRI-visible perivascular spaces as an imaging biomarker in Fabry disease. J Neurol. 2021;268(3):872–8.
Article
CAS
Google Scholar
Wang M-L, Yu M-M, Wei X-E, Li W-B, Li Y-H. Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population. Neurobiol Aging. 2021;100:32–8.
Article
CAS
Google Scholar
Wang ML, Yang DX, Sun Z, Li WB, Zou QQ, Li PY, et al. MRI-visible perivascular spaces associated with cognitive impairment in military veterans with traumatic brain injury mediated by CSF P-tau. Front Psychiatry. 2022;13:921203.
Article
Google Scholar
Chen W, Song X, Zhang Y. Assessment of the Virchow-Robin spaces in Alzheimer disease, mild cognitive impairment, and normal aging, using high-field MR imaging. AJNR Am J Neuroradiol. 2011;32(8):1490–5.
Article
CAS
Google Scholar
Ramirez J, Berezuk C, McNeely AA, Scott CJ, Gao F, Black SE. Visible Virchow-Robin spaces on magnetic resonance imaging of Alzheimer’s disease patients and normal elderly from the Sunnybrook Dementia Study. J Alzheimers Dis. 2015;43(2):415–24.
Article
Google Scholar
Banerjee G, Kim HJ, Fox Z, Jäger HR, Wilson D, Charidimou A, et al. MRI-visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden. Brain. 2017;140(4):1107–16.
Article
Google Scholar
Gertje EC, van Westen D, Panizo C, Mattsson-Carlgren N, Hansson O. Association of enlarged perivascular spaces and measures of small vessel and Alzheimer disease. Neurology. 2021;96(2):e193–202.
Article
CAS
Google Scholar
Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, et al. Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology. 2010;74(3):201–9.
Article
Google Scholar
Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, et al. Development and assessment of a composite score for memory in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Brain Imaging Behav. 2012;6(4):502–16.
Article
Google Scholar
Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, et al. A composite score for executive functioning, validated in Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav. 2012;6(4):517–27.
Article
Google Scholar
Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12(8):822–38.
Article
Google Scholar
Maclullich AM, Wardlaw JM, Ferguson KJ, Starr JM, Seckl JR, Deary IJ. Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry. 2004;75(11):1519–23.
Article
CAS
Google Scholar
Potter GM, Chappell FM, Morris Z, Wardlaw JM. Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability. Cerebrovasc Dis (Basel, Switzerland). 2015;39(3-4):224–31.
Article
Google Scholar
Bown CW, Carare RO, Schrag MS, Jefferson AL. Physiology and clinical relevance of enlarged perivascular spaces in the aging brain. Neurology. 2022;98(3):107–17.
Article
Google Scholar
Riba-Llena I, Jiménez-Balado J, Castañé X, Girona A, López-Rueda A, Mundet X, et al. Arterial stiffness is associated with basal ganglia enlarged perivascular spaces and cerebral small vessel disease load. Stroke. 2018;49(5):1279–81.
Article
Google Scholar
Potter GM, Doubal FN, Jackson CA, Chappell FM, Sudlow CL, Dennis MS, et al. Enlarged perivascular spaces and cerebral small vessel disease. Int J Stroke. 2015;10(3):376–81.
Article
Google Scholar
Choi EY, Park YW, Lee M, Kim M, Lee CS, Ahn SS, et al. Magnetic resonance imaging-visible perivascular spaces in the basal ganglia are associated with the diabetic retinopathy stage and cognitive decline in patients with type 2 diabetes. Front Aging Neurosci. 2021;13:666495.
Article
Google Scholar
Yao M, Zhu YC, Soumaré A, Dufouil C, Mazoyer B, Tzourio C, et al. Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition. Neurobiol Aging. 2014;35(9):2118–25.
Article
Google Scholar
Wang S, Huang P, Zhang R, Hong H, Jiaerken Y, Lian C, et al. Quantity and morphology of perivascular spaces: associations with vascular risk factors and cerebral small vessel disease. J Magn Reson Imaging. 2021;54(4):1326–36.
Article
Google Scholar
Perosa V, Oltmer J, Munting LP, Freeze WM, Auger CA, Scherlek AA, et al. Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex. Acta Neuropathol. 2022;143(3):331–48.
Article
CAS
Google Scholar
Sepehrband F, Barisano G, Sheikh-Bahaei N, Choupan J, Cabeen RP, Lynch KM, et al. Volumetric distribution of perivascular space in relation to mild cognitive impairment. Neurobiol Aging. 2021;99:28–43.
Article
CAS
Google Scholar
van Veluw SJ, Biessels GJ, Bouvy WH, Spliet WG, Zwanenburg JJ, Luijten PR, et al. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab. 2016;36(3):576–80.
Article
Google Scholar
Charidimou A, Boulouis G, Pasi M, Auriel E, van Etten ES, Haley K, et al. MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy. Neurology. 2017;88(12):1157–64.
Article
CAS
Google Scholar
Boespflug EL, Simon MJ, Leonard E, Grafe M, Woltjer R, Silbert LC, et al. Targeted assessment of enlargement of the perivascular space in Alzheimer’s disease and vascular dementia subtypes implicates astroglial involvement specific to Alzheimer’s disease. J Alzheimers Dis. 2018;66(4):1587–97.
Article
Google Scholar
Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife. 2018:7:e40070.
Yakushiji Y, Charidimou A, Hara M, Noguchi T, Nishihara M, Eriguchi M, et al. Topography and associations of perivascular spaces in healthy adults: the Kashima scan study. Neurology. 2014;83(23):2116–23.
Article
Google Scholar
Charidimou A, Meegahage R, Fox Z, Peeters A, Vandermeeren Y, Laloux P, et al. Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study. J Neurol Neurosurg Psychiatry. 2013;84(6):624–9.
Article
Google Scholar
Shams S, Martola J, Charidimou A, Larvie M, Granberg T, Shams M, et al. Topography and determinants of magnetic resonance imaging (MRI)-visible perivascular spaces in a large memory clinic cohort. J Am Heart Assoc. 2017;6(9):e006279.
Zhang C, Chen Q, Wang Y, Zhao X, Wang C, Liu L, et al. Risk factors of dilated Virchow-Robin spaces are different in various brain regions. PLoS One. 2014;9(8):e105505.
Article
Google Scholar
Jiménez-Balado J, Riba-Llena I, Garde E, Valor M, Gutiérrez B, Pujadas F, et al. Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function. J Neurol Neurosurg Psychiatry. 2018;89(6):651–6.
Article
Google Scholar
Hilal S, Tan CS, Adams HHH, Habes M, Mok V, Venketasubramanian N, et al. Enlarged perivascular spaces and cognition: a meta-analysis of 5 population-based studies. Neurology. 2018;91(9):e832–e42.
Article
Google Scholar
Francis F, Ballerini L, Wardlaw JM. Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis. Int J Stroke. 2019;14(4):359–71.
Article
Google Scholar
Paradise M, Crawford JD, Lam BCP, Wen W, Kochan NA, Makkar S, et al. Association of dilated perivascular spaces with cognitive decline and incident dementia. Neurology. 2021;96(11):e1501–e11.
Article
CAS
Google Scholar
Young JJ, Jensen RK, Hartvigsen J, Roos EM, Ammendolia C, Juhl CB. Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2022;23(1):177.
Article
Google Scholar
Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, et al. Using the Alzheimer’s Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer’s disease. Alzheimers Dementia. 2022;18(4):824–57.
Article
Google Scholar
Barisano G, Lynch KM, Sibilia F, Lan H, Shih NC, Sepehrband F, et al. Imaging perivascular space structure and function using brain MRI. Neuroimage. 2022;257:119329.
Article
Google Scholar