Table 2 Group comparisons of MRI-visible PVS and other MRI findings across the Alzheimer’s disease spectrum
Data available | CN | Data available | MCI | Data available | AD | p value | |
|---|---|---|---|---|---|---|---|
CSO-PVS grade | 486 | 667 | 276 | <0.001*,a,b,c | |||
No/mild (grades 0–1), n (%) | 125 (25.7) | 120 (18.0) | 32 (11.6) | ||||
Moderate (grade 2), n (%) | 239 (49.2) | 326 (48.9) | 126 (45.7) | ||||
Frequent/severe (grades 3–4), n (%) | 122 (25.1) | 221 (33.1) | 118 (42.8) | ||||
CSO-PVS number | 15.9 (7.9) | 17.5 (8.4) | 19.0 (8.3) | <0.001*,a,b,c | |||
BG-PVS grade | 486 | 667 | 276 | 0.183 | |||
No/mild (grades 0–1), n (%) | 399 (82.1) | 531 (79.6) | 221 (80.1) | ||||
Moderate (grade 2), n (%) | 78 (16.0) | 126 (18.9) | 45 (16.3) | ||||
Frequent/severe (grades 3–4), n (%) | 9 (1.9) | 10 (1.5) | 10 (3.6) | ||||
BG-PVS number | 7.2 (4.1) | 7.4 (4.1) | 7.7 (4.8) | 0.326 | |||
HP-PVS grade | 486 | 667 | 276 | 0.432 | |||
No/mild (0–1 PVS), n (%) | 137 (28.2) | 200 (30.0) | 93 (33.7) | ||||
Moderate (2–4 PVS), n (%) | 217 (44.7) | 290 (43.5) | 122 (44.2) | ||||
Frequent/severe (>4 PVS), n (%) | 132 (27.2) | 177 (26.5) | 61 (22.1) | ||||
HP-PVS number | 3.2 (2.5) | 3.0 (2.5) | 2.8 (2.3) | 0.182 | |||
WMH volume (cm3) | 486 | 1.25 (0.25, 3.91) | 666 | 0.79 (0.20, 3.28) | 275 | 1.14 (0.24, 3.93) | 0.057 |
HP volume (cm3) | 483 | 7.33 (0.94) | 653 | 6.57 (1.15) | 262 | 5.60 (1.03) | <0.001*,a,b,c |
Intracranial volume, cm3 | 486 | 1415 (138) | 665 | 1442 (145) | 276 | 1420 (157) | 0.005*,a |