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  1. Review

    Communicating mild cognitive impairment diagnoses with and without amyloid imaging

    Mild cognitive impairment (MCI) has an uncertain etiology and prognosis and may be challenging for clinicians to discuss with patients and families. Amyloid imaging may aid specialists in determining MCI etiol...

    Joshua D. Grill, Liana G. Apostolova, Szofia Bullain, Jeffrey M. Burns, Chelsea G. Cox, Malcolm Dick, Dean Hartley, Claudia Kawas, Sarah Kremen, Jennifer Lingler, Oscar L. Lopez, Mark Mapstone, Aimee Pierce, Gil Rabinovici, J. Scott Roberts, Seyed Ahmad Sajjadi…

    Alzheimer's Research & Therapy 2017 9:35

    Published on: 4 May 2017

  2. Research

    Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study

    Safety warnings from health authorities are currently intended to limit the use of antipsychotics (APs) in dementia-related conditions to treat neuropsychiatric symptoms, such as disturbing and/or delusional b...

    Karim Tifratene, Valeria Manera, Roxane Fabre, Auriane Gros, Susanne Thummler, Christian Pradier, Philippe Robert and Renaud David

    Alzheimer's Research & Therapy 2017 9:34

    Published on: 26 April 2017

  3. Research

    Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

    The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in diagnosing Alzheimer’s disease (AD) and predicting the cognitive evolution of p...

    Fayçal Ben Bouallègue, Denis Mariano-Goulart and Pierre Payoux

    Alzheimer's Research & Therapy 2017 9:32

    Published on: 26 April 2017

  4. Research

    Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

    Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptid...

    Doris Lambracht-Washington, Min Fu, Pat Frost and Roger N. Rosenberg

    Alzheimer's Research & Therapy 2017 9:30

    Published on: 26 April 2017

  5. Research

    Memory is preserved in older adults taking AT1 receptor blockers

    Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer’s disease, independent of stroke. Angiotensin II receptor blockers (ARBs) have been highlighte...

    Jean K. Ho and Daniel A. Nation

    Alzheimer's Research & Therapy 2017 9:33

    Published on: 26 April 2017

  6. Review

    The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

    Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influen...

    Sarah Westwood, Benjamine Liu, Alison L. Baird, Sneha Anand, Alejo J. Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R. Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso…

    Alzheimer's Research & Therapy 2017 9:31

    Published on: 26 April 2017

  7. Research

    Multireceptor fingerprints in progressive supranuclear palsy

    Progressive supranuclear palsy (PSP) with a frontal presentation, characterized by cognitive deficits and behavioral changes, has been recognized as an early clinical picture, distinct from the classical so-ca...

    Wang Zheng Chiu, Laura Donker Kaat, Agnita J. W. Boon, Wouter Kamphorst, Axel Schleicher, Karl Zilles, John C. van Swieten and Nicola Palomero-Gallagher

    Alzheimer's Research & Therapy 2017 9:28

    Published on: 17 April 2017

  8. Review

    The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

    Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at risk,...

    Alberto Costa, Thomas Bak, Paolo Caffarra, Carlo Caltagirone, Mathieu Ceccaldi, Fabienne Collette, Sebastian Crutch, Sergio Della Sala, Jean François Démonet, Bruno Dubois, Emrah Duzel, Peter Nestor, Sokratis G. Papageorgiou, Eric Salmon, Sietske Sikkes, Pietro Tiraboschi…

    Alzheimer's Research & Therapy 2017 9:27

    Published on: 17 April 2017

  9. Research

    Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity

    Informal care is essential for many people with dementia (PwD), but it often results in a considerable burden for the caregiver. The perseverance time instrument integrates the aspect of perceived burden with ...

    Anke Richters, René J. F. Melis, N. Job van Exel, Marcel G. M. Olde Rikkert and Marjolein A. van der Marck

    Alzheimer's Research & Therapy 2017 9:26

    Published on: 4 April 2017

  10. Research

    Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

    18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to con...

    Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier and Pedro Rosa-Neto

    Alzheimer's Research & Therapy 2017 9:25

    Published on: 31 March 2017

  11. Research

    Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer’s disease

    The incidence of Alzheimer’s disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investig...

    Frances C. Quevenco, Maria G. Preti, Jiri M. G. van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J. Schreiner, Stefanie C. Steininger, Rafael Meyer, Irene B. Meier, Adam M. Brickman, Sandra E. Leh, Anton F. Gietl, Alfred Buck, Roger M. Nitsch, Klaas P. Pruessmann…

    Alzheimer's Research & Therapy 2017 9:24

    Published on: 31 March 2017

  12. Research

    DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

    The apolipoprotein E ɛ4 (APOE4) allele is the strongest genetic risk factor identified for developing Alzheimer’s disease (AD). Among brain lipids, alteration in the ω-3 polyunsaturated fatty acid docosahexaenoic...

    Hussein N. Yassine, Etienne Croteau, Varun Rawat, Joseph R. Hibbeln, Stanley I. Rapoport, Stephen C. Cunnane and John C. Umhau

    Alzheimer's Research & Therapy 2017 9:23

    Published on: 23 March 2017

  13. Research

    Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning

    Errorless learning (EL) is a method for optimizing learning, which uses feed-forward instructions in order to prevent people from making mistakes during the learning process. The majority of previous studies o...

    Sebastian Voigt-Radloff, Maartje M. E. de Werd, Rainer Leonhart, Danielle H. E. Boelen, Marcel G. M. Olde Rikkert, Klaus Fliessbach, Stefan Klöppel, Bernhard Heimbach, Andreas Fellgiebel, Richard Dodel, Gerhard W. Eschweiler, Lucrezia Hausner, Roy P. C. Kessels and Michael Hüll

    Alzheimer's Research & Therapy 2017 9:22

    Published on: 23 March 2017

  14. Research

    Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population

    Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer’s dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT...

    Thibault Mura, Marieta Baramova, Audrey Gabelle, Sylvaine Artero, Jean-François Dartigues, Hélène Amieva and Claudine Berr

    Alzheimer's Research & Therapy 2017 9:21

    Published on: 23 March 2017

  15. Research

    Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

    Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer’s disease (AD) biomarker because blood is an easily accessible bio-fluid, which can be collected routinely, and Aβ is one of the major hallmarks ...

    Jong-Chan Park, Sun-Ho Han, Hyun Jin Cho, Min Soo Byun, Dahyun Yi, Young Min Choe, Seokjo Kang, Eun Sun Jung, Su Jin Won, Eun Hye Kim, Yu Kyeong Kim, Dong Young Lee and Inhee Mook-Jung

    Alzheimer's Research & Therapy 2017 9:20

    Published on: 22 March 2017

  16. Research

    Cognitive profile in prodromal dementia with Lewy bodies

    Cortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spa...

    Jennifer Kemp, Nathalie Philippi, Clélie Phillipps, Catherine Demuynck, Timothée Albasser, Catherine Martin-Hunyadi, Catherine Schmidt-Mutter, Benjamin Cretin and Frédéric Blanc

    Alzheimer's Research & Therapy 2017 9:19

    Published on: 16 March 2017

  17. Research

    Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

    Alzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive functi...

    Raphael Hesse, Ludwig Lausser, Pauline Gummert, Florian Schmid, Anke Wahler, Cathrin Schnack, Katja S. Kroker, Markus Otto, Hayrettin Tumani, Hans A. Kestler, Holger Rosenbrock and Christine A. F. von Arnim

    Alzheimer's Research & Therapy 2017 9:17

    Published on: 9 March 2017

  18. Review

    Role of neuroinflammation in neurodegeneration: new insights

    Previously, the contribution of peripheral infection to cognitive decline was largely overlooked however, the past 15 years have established a key role for infectious pathogens in the progression of age-relate...

    Róisín M. McManus and Michael T. Heneka

    Alzheimer's Research & Therapy 2017 9:14

    Published on: 4 March 2017

  19. Research

    Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

    The number of people living with dementia is expected to exceed 130 million by 2050, which will have serious personal, social and economic implications. Employing successful intervention and treatment strategi...

    Shea J. Andrews, Ranmalee Eramudugolla, Jorge I. Velez, Nicolas Cherbuin, Simon Easteal and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:16

    Published on: 4 March 2017

  20. Research

    Evaluation of a research diagnostic algorithm for DSM-5 neurocognitive disorders in a population-based cohort of older adults

    There is little information on the application and impact of revised criteria for diagnosing dementia and mild cognitive impairment (MCI), now termed major and mild neurocognitive disorders (NCDs) in the DSM-5...

    Ranmalee Eramudugolla, Moyra E. Mortby, Perminder Sachdev, Chantal Meslin, Rajeev Kumar and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:15

    Published on: 4 March 2017

  21. Research

    Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

    Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer’s disease (AD). In this study, we investigated the association between retinal vascular and structural changes and c...

    S.Mojtaba Golzan, Kathryn Goozee, Dana Georgevsky, Alberto Avolio, Pratishtha Chatterjee, Kaikai Shen, Vivek Gupta, Roger Chung, Greg Savage, Carolyn F. Orr, Ralph N. Martins and Stuart L. Graham

    Alzheimer's Research & Therapy 2017 9:13

    Published on: 1 March 2017

  22. Research

    Proportion of dementia in Australia explained by common modifiable risk factors

    At present, dementia has no known cure. Interventions to delay onset and reduce prevalence of the disease are therefore focused on risk factor reduction. Previous population attributable risk estimates for wes...

    Kimberly Ashby-Mitchell, Richard Burns, Jonathan Shaw and Kaarin J. Anstey

    Alzheimer's Research & Therapy 2017 9:11

    Published on: 17 February 2017

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