Aims and scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports.

Although the primary focus is Alzheimer's disease, the scope encompasses translational research into other neurodegenerative diseases.

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Featured research article: Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease

Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies. In this study, Blanc and colleagues compare grey matter volume and atrophy patterns in prodromal Lewy body dementia and prodromal Alzheimer's disease. They find that atrophy in the anterior insula is associated with the early stages of Lewy body dementia, and suggest using this as a biomarker. Read more

The authors of this article have also written an entry on the BioMed Central blog, On Medicine:
The insula as a biomarker of dementia with Lewy bodies

Featured review: Lung disease as a determinant of cognitive decline and dementia

This review, from Dodd, summarises the evidence of an association between cognition, impaired lung function and obstructive lung disease. It goes on to examine the contribution of neuro-imaging to our understanding of the underlying pathophysiology. While the mechanisms of brain pathology and cognitive impairment are likely to be complex and multi-factorial, there is evidence to suggest a key role for occult cerebrovascular damage independent of traditional vascular risk factors, including smoking.

Alzheimer's Research & Therapy 2015 7:32


Alzheimer's Research & Therapy is edited by Philip Scheltens, Todd Golde and Doug Galasko. Find the full Editorial Board here.


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Alzheimer's Disease International news

The 8th Iberoamerican Congress on Alzheimer's Disease will take place on 15-17 October 2016. Brazil is among the countries with the fastest growing population above 60 years of age, and faces major challenges when it comes to providing care, integration, mobility and services to this group of people. The conference will focus on 'Reinventing the long road: aging and longevity'.

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Featured collection: Lewy Body Dementia

Edited by Ian McKeith and James Galvin, this special series takes a translational view of Lewy body dementia from bedside to bench and back. Visit our collections page to find our full list of special series, including thematic series on Innate immunity and Traumatic brain injury.



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Alzheimer's Research & Therapy is affiliated with Alzheimer's Disease International (ADI), London, United Kingdom.