Aims and scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports.

Although the primary focus is Alzheimer's dementia, the scope encompasses translational research into other neurodegenerative diseases.

Featured research article: Mild versus moderate stages of Alzheimer's disease in routine clinical practice of ChEI therapy

In this study, Carina Wattmo and colleagues aim to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy using a 3-year, prospective, observational, multicentre study. The study highlights the clinical importance of instrumental ADL evaluations in patients at a mild stage of AD, and the importance of optimizing the ChEI dose even for individuals with moderate AD.

Carina Wattmo, Lennart Minthon and Åsa K. Wallin
Alzheimer's Research & Therapy 2016 8:7

Featured review: Lung disease as a determinant of cognitive decline and dementia

This review, from Dodd, summarises the evidence of an association between cognition, impaired lung function and obstructive lung disease. It goes on to examine the contribution of neuro-imaging to our understanding of the underlying pathophysiology. While the mechanisms of brain pathology and cognitive impairment are likely to be complex and multi-factorial, there is evidence to suggest a key role for occult cerebrovascular damage independent of traditional vascular risk factors, including smoking.

Alzheimer's Research & Therapy 2015 7:32


Alzheimer's Research & Therapy is edited by Philip Scheltens and Todd Golde. Find the full Editorial Board here.


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Featured collection: Lewy Body Dementia

Edited by Ian McKeith and James Galvin, this special series takes a translational view of Lewy body dementia from bedside to bench and back. Visit our collections page to find our full list of special series, including thematic series on Innate immunity and Traumatic brain injury.



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Alzheimer's Research & Therapy is affiliated to Alzheimer's Disease International (ADI), London, United Kingdom.