Articles

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

Amyloid is deposited in the walls of arteries and capillaries as cerebral amyloid angiopathy (CAA) in the brains of older individuals and of those with Alzheimer disease (AD). CAA in AD reflects an age-related...

Authors: Roy O Weller, Stephen D Preston, Malavika Subash and Roxana O Carare

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND)

Identifying the causes of dementia is important in the search for effective preventative and treatment strategies. The concept of mild cognitive impairment (MCI), as prodromal dementia, has been useful but rem...

Authors: Blossom CM Stephan, Fiona E Matthews, Kay-Tee Khaw, Carole Dufouil and Carol Brayne

Angiotensins and Alzheimer's disease: a bench to bedside overview

The pathology of Alzheimer's disease (AD) features amyloid β peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk f...

Authors: Patrick G Kehoe

Alzheimer's disease therapeutic research: the path forward

The field of Alzheimer's disease therapeutic research seems poised to bring to clinic the next generation of treatments, moving beyond symptomatic benefits to modification of the underlying neurobiology of the...

Authors: Paul S Aisen

Welcome to Alzheimer's Research & Therapy

Authors: Ann Donnelly, Doug Galasko, Todd Golde, Frances Mulvany and Gordon Wilcock