McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor J-P, Weintraub D, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88–100.
Article
PubMed
PubMed Central
Google Scholar
Rongve A, Brønnick K, Ballard C, Aarsland D. Core and suggestive symptoms of dementia with Lewy bodies cluster in persons with mild dementia. Dement Geriatr Cogn Disord. 2010;29(4):317–24.
Article
PubMed
Google Scholar
Morenas-Rodríguez E, Sala I, Subirana A, Pascual-Goñi E, Sánchez-Saudinós MB, Alcolea D, et al. Clinical subtypes of dementia with Lewy bodies based on the initial clinical presentation. J Alzheimer’s Dis. 2018;64(2):505–13.
Article
Google Scholar
Jellinger KA, Wenning GK, Seppi K. Predictors of survival in dementia with Lewy bodies and Parkinson dementia. Neurodegener Dis. 2007;4(6):428–30.
Article
PubMed
Google Scholar
Halliday GM, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol. 2011;122(2):187–204.
Article
CAS
PubMed
Google Scholar
Van Steenoven I, Aarsland D, Weintraub D, Londos E, Blanc F, Van Der Flier WM, et al. Cerebrospinal fluid Alzheimer’s disease biomarkers across the spectrum of Lewy body diseases: results from a large multicenter cohort on behalf of the European DLB consortium. J Alzheimers Dis. 2016;54(1):287–95.
Article
PubMed
PubMed Central
Google Scholar
van der Zande JJ, Steenwijk MD, ten Kate M, Wattjes MP, Scheltens P, Lemstra AW. Gray matter atrophy in dementia with Lewy bodies with and without concomitant Alzheimer’s disease pathology. Neurobiol Aging. 2018;71:171–8.
Article
PubMed
Google Scholar
Ferreira D, Przybelski SA, Lesnick TG, Lemstra AW, Londos E, Blanc F, et al. β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies. Neurology. 2020;95(24):e3257–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lemstra AW, De Beer MH, Teunissen CE, Schreuder C, Scheltens P, Van Der Flier WM, et al. Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2017;88(2):113–8.
Article
CAS
PubMed
Google Scholar
Oppedal K, Ferreira D, Cavallin L, Lemstra A, ten Kate M, Padovani A, et al. A signature pattern of cortical atrophy in dementia with Lewy bodies: a study on 333 patients from The European DLB Consortium. Alzheimer’s Dement. 2019;15(3):400–9.
Article
Google Scholar
Ferreira D, Nordberg A, Westman E. Biological subtypes of Alzheimer disease. Neurology. 2020;94(10):436–48.
Article
PubMed
PubMed Central
Google Scholar
Oppedal K, Borda MG, Ferreira D, Westman E, Aarsland D. European DLB consortium: diagnostic and prognostic biomarkers in dementia with Lewy bodies, a multicenter international initiative. Neurodegener Dis Manag. 2019;9(5):247–50.
Article
PubMed
Google Scholar
Kramberger MG, Auestad B, Garcia-Ptacek S, Abdelnour C, Olmo JG, Walker Z, et al. Long-term cognitive decline in dementia with Lewy bodies in a large multicenter, international cohort. J Alzheimer’s Dis. 2017;57(3):787–95.
Article
Google Scholar
McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology. 2005;65(12):1863–72.
Article
CAS
PubMed
Google Scholar
McKeith I, Boeve B, Dickson D, Halliday G, Taylor J, Weintraub D, et al. Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88–100.
Article
PubMed
PubMed Central
Google Scholar
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.
Article
CAS
PubMed
Google Scholar
Ferreira D, Verhagen C, Hernández-Cabrera JA, Cavallin L, Guo CJ, Ekman U, et al. Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications. Sci Rep. 2017;7:46263.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ph Scheltens D, Leys FB, Huglo D, Weinstein HC, Vermersch P, Kuiper M, et al. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55:967–72.
Article
Google Scholar
Koedam ELGE, Lehmann M, Van Der Flier WM, Scheltens P, Pijnenburg YAL, Fox N, et al. Visual assessment of posterior atrophy development of a MRI rating scale. Eur Radiol. 2011;21(12):2618–25.
Article
PubMed
PubMed Central
Google Scholar
Ferreira D, Cavallin L, Granberg T, Lindberg O, Aguilar C, Mecocci P, et al. Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4. CSF biomarkers and cognition. Eur Radiol. 2016;26(8):2597–610.
PubMed
Google Scholar
Fazekas F, Chawluk JB, Alavi A. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. Am J Neuroradiol. 1987;8(3):421–6.
PubMed Central
Google Scholar
Cedres N, Ferreira D, Machado A, Shams S, Sacuiu S, Waern M, Wahlund L-O, Zettergren A, Kern S, Ingmar Skoog EW. Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities. Aging (Albany NY). 2020;12(1):894–901.
Bos I, Verhey FR, Ramakers IHGB, Jacobs HIL, Soininen H, Freund-Levi Y, et al. Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer’s Res Ther. 2017;9(1):101.
Article
Google Scholar
Abdelnour C, van Steenoven I, Londos E, Blanc F, Auestad B, Kramberger MG, et al. Alzheimer’s disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia. Mov Disord. 2016;31(8):1203–8.
Article
CAS
PubMed
Google Scholar
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Budd Haeberlein S, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535–62.
Article
PubMed
PubMed Central
Google Scholar
Kantarci K, Lowe VJ, Boeve BF, Senjem ML, Tosakulwong N, Lesnick TG, et al. AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies. Ann Neurol. 2017;81(1):58–67.
Article
CAS
PubMed
Google Scholar
Smith R, Schöll M, Londos E, Ohlsson T, Hansson O. F-AV-1451 in Parkinson’s disease with and without dementia and in dementia with Lewy bodies. Sci Rep. 2018;8(1):4717.
Article
PubMed
PubMed Central
Google Scholar
Gomperts S, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, et al. Tau PET imaging in the Lewy body diseases. J AMA Neurol. 2016;73(11):1334–41.
Google Scholar
Lê S, Josse J, Husson F. FactoMineR: an R package for multivariate analysis. J Stat Softw. 2008;25(1):1–18.
Article
Google Scholar
Ward JH. Hierarchical grouping to optimize an objective function. J Am Stat Assoc. 1963;58(301):236–44.
Article
Google Scholar
Calinski T, Harabasz J. A dendrite method foe cluster analysis. Commun Stat. 1974;3(1):1–27.
Google Scholar
Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med. 1990;9(7):811–8.
Article
CAS
PubMed
Google Scholar
Mouton A, Blanc F, Gros A, Manera V, Fabre R, Sauleau E, et al. Sex ratio in dementia with Lewy bodies balanced between Alzheimer’s disease and Parkinson’s disease dementia: a cross-sectional study. Alzheimer’s Res Ther. 2018;10(1):92.
Article
CAS
Google Scholar
Ferman TJ, Aoki N, Crook JE, Murray ME, Graff-Radford NR, van Gerpen JA, et al. The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies. Alzheimer’s Dement. 2018;14(3):330–9.
Article
Google Scholar
Barnes LL, Lamar M, Schneider JA. Sex differences in mixed neuropathologies in community-dwelling older adults. Brain Res. 2019;1719:11–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, et al. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol. 2010;257(11):1875–81.
Article
PubMed
PubMed Central
Google Scholar
O’Dowd S, Schumacher J, Burn DJ, Bonanni L, Onofrj M, Thomas A, et al. Fluctuating cognition in the Lewy body dementias. Brain. 2019;142(11):3338–50.
Article
PubMed
Google Scholar
Nedelska Z, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Murray ME, et al. Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2015;36(1):452–61.
Article
PubMed
Google Scholar
Harper L, Bouwman F, Burton EJ, Barkhof F, Scheltens P, O’brien JT, et al. Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis. J Neurol Neurosurg Psychiatry. 2017;88:908–16.
Article
PubMed
Google Scholar
Whitwell JL, Weigand SD, Shiung MM, Boeve BF, Ferman TJ, Smith GE, et al. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer’s disease. Brain. 2007;130(3):708–19.
Article
PubMed
Google Scholar
Ferreira D, Nedelska Z, Graff-Radford J, Przybelski SA, Lesnick TG, Schwarz CG, et al. Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies. Neurobiol Aging. 2021;105:252–61.
Article
CAS
PubMed
Google Scholar
Abdelnour C, Ferreira D, Oppedal K, Cavallin L, Bousiges O, Wahlund LO, et al. The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies. NeuroImage Clin. 2020;27:102333.
Article
PubMed
PubMed Central
Google Scholar
Mak E, Donaghy PC, McKiernan E, Firbank MJ, Lloyd J, Petrides GS, et al. Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies. Neurobiol Aging. 2019;73:74–81.
Article
CAS
PubMed
Google Scholar
Sarro L, Senjem ML, Lundt ES, Przybelski SA, Lesnick TG, Graff-Radford J, et al. Amyloid-b deposition and regional grey matter atrophy rates in dementia with Lewy bodies. Brain. 2016;139:2740–50.
Article
PubMed
PubMed Central
Google Scholar
Joki H, Higashiyama Y, Nakae Y, Kugimoto C, Doi H, Kimura K, et al. White matter hyperintensities on MRI in dementia with Lewy bodies, Parkinson’s disease with dementia, and Alzheimer’s disease. J Neurol Sci. 2018;385:99–104.
Article
PubMed
Google Scholar
Jellinger KA, Attems J. Cerebral amyloid angiopathy in Lewy body disease. J Neural Transm. 2008;115(3):473–82.
Article
CAS
PubMed
Google Scholar
Smith R, Schöll M, Londos E, Ohlsson T, Hansson O. 18F-AV-1451 in Parkinson’s disease with and without dementia and in dementia with Lewy bodies. Sci Rep. 2018;8(1):4717.
Article
PubMed
PubMed Central
Google Scholar
Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, et al. Tau positron emission tomographic imaging in the Lewy body diseases. JAMA Neurol. 2016;73(11):1334–41.
Article
PubMed
PubMed Central
Google Scholar
Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol. 2017;16(1):55.
Article
PubMed
PubMed Central
Google Scholar
Poulakis K, Ferreira D, Pereira JB, Smedby Ö, Vemuri P, Westman E. Fully Bayesian longitudinal unsupervised learning for the assessment and visualization of AD heterogeneity and progression. Aging (Albany NY). 2020;12(13):12622–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tiraboschi P, Attems J, Thomas A, Brown Evelyn Jaros A, Lett DJ, Maria Ossola B, et al. Clinicians’ ability to diagnose dementia with Lewy bodies is not affected by β-amyloid load. Neurology. 2015;84(5):496–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Censo R, Abdelnour C, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, et al. CSF tau proteins correlate with an atypical clinical presentation in dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2020;91(1):109–10.
Article
PubMed
Google Scholar
Del Ser T, Hachinski V, Merskey H, Munoz DG. Clinical and pathologic features of two groups of patients with dementia with Lewy bodies: effect of coexisting Alzheimer-type lesion load. Alzheimer Dis Assoc Disord. 2001;15(1):31–44.
Article
PubMed
Google Scholar
Weisman D, Cho M, Taylor C, Adame A, Thal LJ, Hansen LA. In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology. 2007;69(4):356–9.
Article
CAS
PubMed
Google Scholar
Murray ME, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Liesinger AM, et al. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology. 2013;81(19):1681–9.
Article
PubMed
PubMed Central
Google Scholar
Ferman TJ, Aoki N, Boeve BF, Aakre JA, Kantarci K, Graff-Radford J, et al. Subtypes of dementia with Lewy bodies are associated with α-synuclein and tau distribution. Neurology. 2020;95(2):E155–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pilotto A, Romagnolo A, Tuazon JA, Vizcarra JA, Marsili L, Zibetti M, et al. Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in α-synucleinopathies. J Neurol Neurosurg Psychiatry. 2019;90(11):1257–63.
Article
PubMed
Google Scholar
La JR, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, et al. Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET. Sci Transl Med. 2020;12(524):5732.
Article
Google Scholar
Cho H, Choi JY, Hwang MS, Kim YJ, Lee HM, Lee HS, et al. In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. Ann Neurol. 2016;80(2):247–58.
Article
CAS
PubMed
Google Scholar
Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, et al. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease. Brain. 2017;140(12):3286–300.
Article
PubMed
PubMed Central
Google Scholar
Petrova T, Orellana C, Jelic V, Oeksengaard AR, Snaedal J, Høgh P, et al. Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases. Psychiatry Res Neuroimaging. 2020;302:111099.
Article
PubMed
Google Scholar
Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, et al. Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Ann Clin Transl Neurol. 2016;3(10):812–8.
Article
CAS
PubMed
PubMed Central
Google Scholar