Table 1 Characteristics of the whole cohort and DLB clusters

Age

68 (± 8.7)

70 (± 7.2)^b,d

64 (± 7.7)^a,c

71 (± 10)^a,d

64 (± 6.9)^a,c

0.001

Sex, n men (%)

77 (72.0%)

28 (71.8%)

21 (84.0%)^d

21 (87.5%)^d

7 (36.8%)^b,c

0.001

Education, years mean (SD)

11 (± 3.8)

11 (± 2.8)^b,d

8.2 (± 2.4)^a,c,d

12 (± 3.5)^a,d

15 (± 3.3)^a,b,c

<0.001

Disease duration, years mean (SD)

4.3 (± 3.8)

4.2 (± 4.9)^d

3.7 (± 2.7)^d

3.5 (± 2.3)^d

6.3 (± 3.8)^a,b,c

0.013

MMSE score, mean (SD)

25 (± 4.0)

24 (± 3.9)^d

22 (± 3.9)^d

25 (± 3.8)^d

28 (± 2.0)^a,b,c

<0.001

 Parkinsonism, n present (%)

87 (81 %)

33 (85 %)^c

25 (100%)^c

11 (46 %)^a,b,d

18 (95 %)^c

<0.001

 Visual hallucinations, n present (%)

68 (64 %)

29 (74 %)^b

8 (32 %)^a

17 (71 %)

14 (74 %)

0.003

 Cognitive fluctuations, n present (%)

90 (84 %)

39 (100 %)^b

12 (48 %)^a,d

20 (83 %)

19 (100 %)^b

<0.001

 Probable RBD, n present (%)

68 (64 %)

23 (59 %)

20 (80 %)

15 (62 %)

10 (53 %)

0.234

 Aβ42, n abnormal (%)

31 (29 %)

16 (41 %)

6 (24 %)

8 (33 %)

1 (5 %)

0.037*

 Total tau, n abnormal (%)

23 (21 %)

4 (10 %)^c

0 (0 %)^c

19 (79 %)^a,b,d

0 (0 %)^c

<0.001

 p-tau, n abnormal (%)

38 (36 %)

11 (28 %)^c

4 (16 %)^c

23 (96 %)^a,b,d

0 (0 %)^c

<0.001

 AD CSF profile, n abnormal (%)

<0.001

  AD pathology

12 (11 %)

3 (8 %)

1 (4 %)

8 (33 %)

0 (0 %)

  AD pathological change

19 (18 %)

13 (33 %)

5 (20%)

0 (0 %)

1 (5%)

  Amyloid independent tau-pathology

26 (24 %)

8 (21 %)

3 (12 %)

15 (63 %)

0 (0 %)

  Normal

50 (47 %)

15 (38 %)

16 (64 %)

1 (4 %)

18 (95 %)

 MTA, n abnormal (%)

35 (33 %)

23 (59 %)^b,c

5 (20 %)^a

3 (12 %)^a

4 (21 %)

<0.001

 GCA-F, n abnormal (%)

42 (39 %)

20 (51 %)^d

11 (44 %)^d

11 (46 %)^d

0 (0 %)^a,b,c

0.002

 PA, n abnormal (%)

61 (57 %)

19 (49 %)

19 (76 %)^d

19 (79 %)^d

4 (21 %)^b,c

<0.001

 Fazekas, n high WMH burden (%)

29/92 (32%)§

15/32 (47%)^d

6/24 (25%)

7/18 (39%)

1/17 (6%)^a

0.018