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  1. Crenezumab, a fully humanized anti-beta-amyloid (Aβ) immunoglobulin G4 (IgG4) monoclonal antibody, binds to both monomeric and aggregated forms of Aβ. We assessed the pharmacokinetics (PK)/pharmacodynamics (PD...

    Authors: Kenta Yoshida, Anita Moein, Tobias Bittner, Susanne Ostrowitzki, Helen Lin, Lee Honigberg, Jin Y. Jin and Angelica Quartino

    Citation: Alzheimer's Research & Therapy 2020 12:16

    Content type: Research

    Published on:

  2. Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid...

    Authors: Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter and Christopher H. van Dyck

    Citation: Alzheimer's Research & Therapy 2020 12:15

    Content type: Research

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  3. Although structural and functional changes of the striatum and hippocampus are present in familial Alzheimer’s disease, little is known about the effects of specific gene mutation or disease progression on the...

    Authors: Meina Quan, Tan Zhao, Yi Tang, Ping Luo, Wei Wang, Qi Qin, Tingting Li, Qigeng Wang, Jiliang Fang and Jianping Jia

    Citation: Alzheimer's Research & Therapy 2020 12:14

    Content type: Research

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  4. Mounting evidence points to a crucial role of amyloid-β (Aβ) in the pathophysiology of Alzheimer’s disease (AD), a disorder in which brain glucose hypometabolism, downregulation of central elements of phosphor...

    Authors: Krystal Sotolongo, Jorge Ghiso and Agueda Rostagno

    Citation: Alzheimer's Research & Therapy 2020 12:13

    Content type: Research

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    The Correction to this article has been published in Alzheimer's Research & Therapy 2020 12:32

  5. Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make ...

    Authors: Helen Crehan, Bin Liu, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Kevin X. Le, Barbara J. Caldarone, Jeffrey L. Frost, Thore Hettmann, Birgit Hutter-Paier, Brian O’Nuallain, Mi-Ae Park, Marcelo F. DiCarli, Inge Lues, Stephan Schilling and Cynthia A. Lemere

    Citation: Alzheimer's Research & Therapy 2020 12:12

    Content type: Research

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  6. Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Othe...

    Authors: Víctor Costumero, Lidon Marin-Marin, Marco Calabria, Vicente Belloch, Joaquín Escudero, Miguel Baquero, Mireia Hernandez, Juan Ruiz de Miras, Albert Costa, Maria-Antònia Parcet and César Ávila

    Citation: Alzheimer's Research & Therapy 2020 12:11

    Content type: Research

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  7. To date, no symptomatic treatment is available for patients with vascular cognitive impairment (VCI). In the proof-of-principle study Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI), we inv...

    Authors: Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier and Niels D. Prins

    Citation: Alzheimer's Research & Therapy 2020 12:10

    Content type: Research

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  8. Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to character...

    Authors: Oriol Grau-Rivera, Grégory Operto, Carles Falcón, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Anna Brugulat-Serrat, Nina Gramunt, Gemma Salvadó, Marc Suárez-Calvet, Carolina Minguillon, Álex Iranzo, Juan Domingo Gispert and José Luis Molinuevo

    Citation: Alzheimer's Research & Therapy 2020 12:4

    Content type: Research

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  9. Fluctuations are one of the core clinical features characterizing dementia with Lewy bodies (DLB). They represent a determining factor for its diagnosis and strongly impact the quality of life of patients and ...

    Authors: Eléna Chabran, Vincent Noblet, Paulo Loureiro de Sousa, Catherine Demuynck, Nathalie Philippi, Catherine Mutter, Pierre Anthony, Catherine Martin-Hunyadi, Benjamin Cretin and Frédéric Blanc

    Citation: Alzheimer's Research & Therapy 2020 12:9

    Content type: Research

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  10. Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD pathology...

    Authors: Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins…

    Citation: Alzheimer's Research & Therapy 2020 12:8

    Content type: Research

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  11. Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional co...

    Authors: Chemin Lin, Maria Ly, Helmet T. Karim, Wenjing Wei, Beth E. Snitz, William E. Klunk and Howard J. Aizenstein

    Citation: Alzheimer's Research & Therapy 2020 12:7

    Content type: Research

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  12. Although amyloid PET of typical Alzheimer’s disease (AD) shows diffuse ß-amyloid (Aß) deposition, some patients show focal deposition. The clinical significance of this focal Aß is not well understood. We exam...

    Authors: Si Eun Kim, Byungju Lee, Seongbeom Park, Soo Hyun Cho, Seung Joo Kim, Yeshin Kim, Hyemin Jang, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Na Yeon Jung, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Jihye Hwang…

    Citation: Alzheimer's Research & Therapy 2020 12:6

    Content type: Research

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  13. Alzheimer's disease (AD) is frequently accompanied by sleep impairment, which can induce AD-related neurodegeneration. We herein investigated the sleep architecture, cognition, and cerebrospinal fluid (CSF) bi...

    Authors: Claudio Liguori, Fabio Placidi, Francesca Izzi, Matteo Spanetta, Nicola Biagio Mercuri and Alessandra Di Pucchio

    Citation: Alzheimer's Research & Therapy 2020 12:5

    Content type: Research

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    The Correction to this article has been published in Alzheimer's Research & Therapy 2020 12:53

  14. Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker of axonal degeneration, have previously been reported to be raised in patients with clinically diagnosed Alzheimer’s disease (AD). A...

    Authors: Peter Parbo, Lasse Stensvig Madsen, Rola Ismail, Henrik Zetterberg, Kaj Blennow, Simon F. Eskildsen, Thomas Vorup-Jensen and David J. Brooks

    Citation: Alzheimer's Research & Therapy 2020 12:3

    Content type: Research

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  15. In neurodegenerative dementias (NDs) such as prion disease, Alzheimer’s disease (AD), and frontotemporal lobar degeneration (FTLD), protein misfolding leads to the tissue deposition of protein aggregates which...

    Authors: Samir Abu-Rumeileh, Petra Steinacker, Barbara Polischi, Angela Mammana, Anna Bartoletti-Stella, Patrick Oeckl, Simone Baiardi, Corrado Zenesini, André Huss, Pietro Cortelli, Sabina Capellari, Markus Otto and Piero Parchi

    Citation: Alzheimer's Research & Therapy 2019 12:2

    Content type: Research

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  16. Insulin impairment and inflammation are two features common to type 2 diabetes and Alzheimer’s disease; however, the molecular and signaling interactions underlying this relationship are not well understood. M...

    Authors: Maria Elizabeth De Sousa Rodrigues, Madelyn C. Houser, Douglas I. Walker, Dean P. Jones, Jianjun Chang, Christopher J. Barnum and Malú G. Tansey

    Citation: Alzheimer's Research & Therapy 2019 12:1

    Content type: Research

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  17. The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer’s disease (AD) brain. The results so far hav...

    Authors: Iliya Lefterov, Cody M. Wolfe, Nicholas F. Fitz, Kyong Nyon Nam, Florent Letronne, Richard J. Biedrzycki, Julia Kofler, Xianlin Han, Jianing Wang, Jonathan Schug and Radosveta Koldamova

    Citation: Alzheimer's Research & Therapy 2019 11:113

    Content type: Research

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  18. Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several ...

    Authors: A. C. van Loenhoud, C. de Boer, K. Wols, Y. A. Pijnenburg, A. W. Lemstra, F. H. Bouwman, N. D. Prins, P. Scheltens, R. Ossenkoppele and W. M. van der Flier

    Citation: Alzheimer's Research & Therapy 2019 11:112

    Content type: Research

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  19. Due to the high cost and high failure rate of ascertaining amyloid positron emission tomography positivity (PET+) in patients with earlier stage Alzheimer’s disease (AD), an effective pre-screening tool for am...

    Authors: Szu-Ying Lin, Kun-Ju Lin, Po-Chen Lin, Chin-Chang Huang, Chiung-Chih Chang, Yi-Chung Lee, Ing-Tsung Hsiao, Tzu-Chen Yen, Wen-Sheng Huang, Bang-Hung Yang and Pei-Ning Wang

    Citation: Alzheimer's Research & Therapy 2019 11:111

    Content type: Research

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  20. The persistence of adult hippocampal neurogenesis (AHN) is sharply decreased in Alzheimer’s disease (AD). The neuropathologies of AD include the presence of amyloid-β deposition in plaques, tau hyperphosphoryl...

    Authors: Jaewoo Shin, Chanho Kong, Jihyeon Lee, Bo Young Choi, Jiyeon Sim, Chin Su Koh, Minkyung Park, Young Cheol Na, Sang Won Suh, Won Seok Chang and Jin Woo Chang

    Citation: Alzheimer's Research & Therapy 2019 11:110

    Content type: Research

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  21. We examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes.

    Authors: Jessica Z. K. Caldwell, Jeffrey L. Cummings, Sarah J. Banks, Sebastian Palmqvist and Oskar Hansson

    Citation: Alzheimer's Research & Therapy 2019 11:109

    Content type: Research

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  22. Cortical and subcortical cognitive impairments are usually found in dementia with Lewy bodies (DLB). Roughly, they comprise visuo-constructive/executive function and attention/processing speed impairments, whe...

    Authors: Anne Botzung, Nathalie Philippi, Vincent Noblet, Paulo Loureiro de Sousa and Frédéric Blanc

    Citation: Alzheimer's Research & Therapy 2019 11:108

    Content type: Research

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  23. Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive ...

    Authors: Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A. Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones and Anahit Ghochikyan

    Citation: Alzheimer's Research & Therapy 2019 11:107

    Content type: Research

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  24. Brain amyloid deposition is one of the main pathological characteristics of Alzheimer’s disease (AD). Soluble oligomers formed during the process that causes β-amyloid (Aβ) to aggregate into plaques are consid...

    Authors: Jian-Xiang Zhang, Yi-Hui Lai, Pan-Ying Mi, Xue-Ling Dai, Ran Zhang, Zhan-Jun Zhang, Shu-Juan Zhang, Xi-Wen Zhang, Xi-Yan Zhang, Bing-Yu Yang, Dong-Mei Cui, Chen Zhang, Chang-Qi Zhao and Fei Dou

    Citation: Alzheimer's Research & Therapy 2019 11:106

    Content type: Research

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  25. Increased CSF levels of a number of synaptic markers have been reported in Alzheimer’s disease (AD), but little is known about their concentrations in frontotemporal dementia (FTD). We investigated this in thr...

    Authors: Mica T. M. Clarke, Ann Brinkmalm, Martha S. Foiani, Ione O. C. Woollacott, Carolin Heller, Amanda Heslegrave, Ashvini Keshavan, Nick C. Fox, Jonathan M. Schott, Jason D. Warren, Kaj Blennow, Henrik Zetterberg and Jonathan D. Rohrer

    Citation: Alzheimer's Research & Therapy 2019 11:105

    Content type: Research

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  26. The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-be...

    Authors: Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli and Roberta Rizzo

    Citation: Alzheimer's Research & Therapy 2019 11:104

    Content type: Research

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  27. Since both APOE and ABCA7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we ...

    Authors: Ya-Ting Chang, Shih-Wei Hsu, Shu-Hua Huang, Chi-Wei Huang, Wen-Neng Chang, Chia-Yi Lien, Jun-Jun Lee, Chen-Chang Lee and Chiung-Chih Chang

    Citation: Alzheimer's Research & Therapy 2019 11:103

    Content type: Research

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  28. EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfun...

    Authors: Lindsay Poppe, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Zsuzsanna Callaerts-Vegh, Gilles Courtand, Antina de Boer, Silke Smolders, Philip Van Damme, Ludo Van Den Bosch, Rudi D’Hooge, Bart De Strooper, Wim Robberecht and Robin Lemmens

    Citation: Alzheimer's Research & Therapy 2019 11:102

    Content type: Research

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  29. We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor-mediated phagocytosis, in the SCarlet RoAD (SR...

    Authors: Gregory Klein, Paul Delmar, Nicola Voyle, Sunita Rehal, Carsten Hofmann, Danielle Abi-Saab, Mirjana Andjelkovic, Smiljana Ristic, Guoqiao Wang, Randall Bateman, Geoffrey A. Kerchner, Monika Baudler, Paulo Fontoura and Rachelle Doody

    Citation: Alzheimer's Research & Therapy 2019 11:101

    Content type: Research

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  30. Amyloid-β PET and CSF Aβ42 yield discordant results in 10–20% of memory clinic patients, possibly providing unique information. Although the predictive power of demographic, clinical, genetic, and imaging feature...

    Authors: Juhan Reimand, Arno de Wilde, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Frederik Barkhof, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Rik Ossenkoppele and Femke Bouwman

    Citation: Alzheimer's Research & Therapy 2019 11:100

    Content type: Research

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  31. Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer’s disease (AD) relies on dichotomous biomarker cut-off values. Individuals with mild cognitive impairment (MCI) and Aβ within t...

    Authors: Anna Rosenberg, Alina Solomon, Vesna Jelic, Göran Hagman, Nenad Bogdanovic and Miia Kivipelto

    Citation: Alzheimer's Research & Therapy 2019 11:99

    Content type: Research

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  32. Dementia has been presenting an imminent public health challenge worldwide. Studies have shown a combination of cognitive and physical trainings may have synergistic value for improving cognitive functions. Da...

    Authors: Lawla L. F. Law, Vincent C. T. Mok and Matthew M. K. Yau

    Citation: Alzheimer's Research & Therapy 2019 11:98

    Content type: Research

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  33. Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglob...

    Authors: William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji and Jasvinder K. Atwal

    Citation: Alzheimer's Research & Therapy 2019 11:97

    Content type: Research

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  34. To facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer’s disease, supportive biomarker information is necessary. This study was aimed to investigate the association...

    Authors: Virginia Pérez-Grijalba, Javier Arbizu, Judith Romero, Elena Prieto, Pedro Pesini, Leticia Sarasa, Fernando Guillen, Inmaculada Monleón, Itziar San-José, Pablo Martínez-Lage, Josep Munuera, Isabel Hernández, Mar Buendía, Oscar Sotolongo-Grau, Montserrat Alegret, Agustín Ruiz…

    Citation: Alzheimer's Research & Therapy 2019 11:96

    Content type: Research

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  35. The development of diagnostic tools capable of accurately identifying the pathophysiology of mild cognitive impairment (MCI) has become a crucial target considering the claim that disease-modifying treatments ...

    Authors: Alessandro Padovani, Alberto Benussi, Maria Sofia Cotelli, Clarissa Ferrari, Valentina Cantoni, Valentina Dell’Era, Rosanna Turrone, Barbara Paghera and Barbara Borroni

    Citation: Alzheimer's Research & Therapy 2019 11:95

    Content type: Research

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  36. Results from recent clinical studies suggest that cerebrospinal fluid (CSF) biomarkers that are indicative of Alzheimer’s disease (AD) can be replicated in blood, e.g. amyloid-beta peptides (Aβ42 and Aβ40) and ne...

    Authors: Nicholas J. Ashton, Marc Suárez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L. Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K. Hodges and Henrik Zetterberg

    Citation: Alzheimer's Research & Therapy 2019 11:94

    Content type: Research

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  37. Metabolic alterations, related to cerebral glucose metabolism, brain insulin resistance, and age-induced mitochondrial dysfunction, play an important role in Alzheimer’s disease (AD) on both the systemic and c...

    Authors: Vera van der Velpen, Tony Teav, Héctor Gallart-Ayala, Florence Mehl, Ioana Konz, Christopher Clark, Aikaterini Oikonomidi, Gwendoline Peyratout, Hugues Henry, Mauro Delorenzi, Julijana Ivanisevic and Julius Popp

    Citation: Alzheimer's Research & Therapy 2019 11:93

    Content type: Research

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  38. Alzheimer’s disease (AD) clinical trials require enrollment of a participant and a study partner, whose role includes assessing participant cognitive and functional performance. AD trials now investigate early...

    Authors: Michelle M. Nuño, Daniel L. Gillen and Joshua D. Grill

    Citation: Alzheimer's Research & Therapy 2019 11:92

    Content type: Research

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  39. Ongoing efforts within the Alzheimer’s disease (AD) field have focused on improving the intra- and inter-laboratory variability for cerebrospinal fluid (CSF) biomarkers. Fully automated assays offer the possib...

    Authors: Maria João Leitão, Anuschka Silva-Spínola, Isabel Santana, Veronica Olmedo, Alicia Nadal, Nathalie Le Bastard and Inês Baldeiras

    Citation: Alzheimer's Research & Therapy 2019 11:91

    Content type: Research

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  40. It has been claimed that the retina can be used as a window to study brain disorders. However, concerning Alzheimer’s disease (AD), it still remains controversial whether changes occurring in the brain and ret...

    Authors: Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco and António Francisco Ambrósio

    Citation: Alzheimer's Research & Therapy 2019 11:90

    Content type: Research

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  41. The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) bet...

    Authors: Xue Meng, Tao Li, Xiao Wang, Xiaozhen Lv, Zhiyu Sun, Jichun Zhang, Feng Su, Sungmin Kang, SangYun Kim, Seong Soo A. An, Xin Yu, Chen Zhang and Huali Wang

    Citation: Alzheimer's Research & Therapy 2019 11:89

    Content type: Research

    Published on:

  42. Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and...

    Authors: Dávid Nagy, Lauren Herl Martens, Liza Leventhal, Angela Chen, Craig Kelley, Milan Stoiljkovic and Mihály Hajós

    Citation: Alzheimer's Research & Therapy 2019 11:88

    Content type: Research

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  43. Physical activity might reduce the risk of developing dementia. However, it is still unclear whether the protective effect differs depending on the subtype of dementia. We aimed to investigate if midlife physi...

    Authors: Oskar Hansson, Martina Svensson, Anna-Märta Gustavsson, Emelie Andersson, Yiyi Yang, Katarina Nägga, Ulf Hållmarker, Stefan James and Tomas Deierborg

    Citation: Alzheimer's Research & Therapy 2019 11:87

    Content type: Research

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  44. Repeated failure of drug candidates targeting Alzheimer’s disease (AD) in clinical trials likely stems from a lack of understanding of the molecular mechanisms underlying AD pathogenesis. Recent research has h...

    Authors: Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M. Seidler, Kevin A. Murray, Gal Bitan and Lin Jiang

    Citation: Alzheimer's Research & Therapy 2019 11:86

    Content type: Research

    Published on:

    The Correction to this article has been published in Alzheimer's Research & Therapy 2021 13:83

  45. Preclinical Alzheimer’s disease (AD) clinical trials require participants to enroll with a study partner, a person who can attend visits and report changes in the participant’s cognitive ability. Whether study...

    Authors: Mary M. Ryan, Joshua D. Grill and Daniel L. Gillen

    Citation: Alzheimer's Research & Therapy 2019 11:85

    Content type: Research

    Published on:

  46. According to the 2018 NIA-AA research framework, Alzheimer’s disease (AD) is not defined by the clinical consequences of the disease, but by its underlying pathology, measured by biomarkers. Evidence of both a...

    Authors: Tiziana Carandini, Andrea Arighi, Luca Sacchi, Giorgio G. Fumagalli, Anna M. Pietroboni, Laura Ghezzi, Annalisa Colombi, Marta Scarioni, Chiara Fenoglio, Milena A. De Riz, Giorgio Marotta, Elio Scarpini and Daniela Galimberti

    Citation: Alzheimer's Research & Therapy 2019 11:84

    Content type: Research

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  47. One of the major challenges in diagnosing dementia with Lewy bodies (DLB) is the common co-morbid presence of amyloid pathology. To understand the putative role of altered amyloid-β (Aβ) metabolism in dementia...

    Authors: Inger van Steenoven, Wiesje M. van der Flier, Philip Scheltens, Charlotte E. Teunissen and Afina W. Lemstra

    Citation: Alzheimer's Research & Therapy 2019 11:83

    Content type: Research

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  48. Increasing evidence implicates dysfunctional proteostasis and the involvement of the autophagic and endo-lysosomal system and the ubiquitin-proteasome system in neurodegenerative diseases. In Alzheimer’s disea...

    Authors: Simon Sjödin, Gunnar Brinkmalm, Annika Öhrfelt, Lucilla Parnetti, Silvia Paciotti, Oskar Hansson, John Hardy, Kaj Blennow, Henrik Zetterberg and Ann Brinkmalm

    Citation: Alzheimer's Research & Therapy 2019 11:82

    Content type: Research

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  49. We aimed to assess the relationship between levels of a cerebrospinal fluid (CSF) marker of pericyte damage, soluble platelet-derived growth factor receptor β (sPDGFRβ) and CSF markers of blood-brain barrier (...

    Authors: J. S. Miners, P. G. Kehoe, S. Love, H. Zetterberg and K. Blennow

    Citation: Alzheimer's Research & Therapy 2019 11:81

    Content type: Research

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  50. In vivo, high cerebral amyloid-β load has been associated with (i) reduced concentrations of Aβ42 in cerebrospinal fluid and (ii) increased retention using amyloid-β positron emission tomography. Although these t...

    Authors: Arno de Wilde, Juhan Reimand, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Femke Bouwman and Rik Ossenkoppele

    Citation: Alzheimer's Research & Therapy 2019 11:78

    Content type: Research

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  • ISSN: 1758-9193 (electronic)

Alzheimer's Research & Therapy

ISSN: 1758-9193

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