Table 1 Principal sociodemographic and clinical characteristics of studied subjects: Alzheimer’s disease (AD), behavioural variant frontotemporal dementia (bvFTD), mild cognitive impairment (MCI), psychiatric disorders (Psy), and controls (Con). Values are expressed as mean ± SEM

Number

48

22

20

13

21

Age (years)

69.8 ± 1.1

70.5 ± 1.5

67.3 ± 1.9

62.8 ± 2.3

70.1 ± 1.1

Gender (M:F)

22:26

10:12

10:10

8:5

15:6

Education (years ± SEM)

10.0 ± 0.6

9.9 ± 1.0

10.1 ± 0.8

13.0 ± 1.2

10.4 ± 0.9

Disease duration (years ± SEM)

3.1 ± 0.3

2.3 ± 0.3

2.7 ± 0.4

5.7 ± 2.7

4.0 ± 0.9

MMSE ± SEM

21.2 ± 0.9

23.1 ± 1.2

25.9 ± 0.5

27.2 ± 0.7

27.4 ± 1.0

Beta-amyloid (pg/ml ± SEM)

397.6 ± 20.9

586.3 ± 47.6

760.7 ± 69.6

844.9 ± 124.2

805.2 ± 72.8

Total tau (pg/ml ± SEM)

909.8 ± 72.8

552.2 ± 83.7

306.8 ± 29.1

253.0 ± 31.8

312.1 ± 25.7

P-Tau (pg/ml ± SEM)

149.6 ± 11.3

76.2 ± 13.8

42.3 ± 4.4

36.3 ± 5.8

48.3 ± 5.0

AQP4 (pg/ml ± SEM)

350.4 ± 32.7

310.5 ± 34.6

266.2 ± 25.0

261.6 ± 32.1

209.6 ± 23.4