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Table 4 Correlations between the plasma IgA levels and neuropathology as well as hippocampal IgA area fraction and IgA-positive cell number in cohort II

From: Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Variables All groups NC AD APOEε4 +APOEε4
Aβ (score) ns ns ns 0.741** ns
LB (score) ns ns ns 0.702* ns
NFT (score) ns ns ns 0.840*** ns
IgA+ cells (no.) 0.560** ns ns 0.893*** ns
IgA area fraction (%) 0.688*** ns 0.564* 0.918*** 0.618*
  1. Data were analysed using Spearman’s correlation test
  2. amyloid beta, AD Alzheimer’s disease, APOE4 apolipoprotein 4, −APOEε4 APOEε4 non-carrier, +APOEε4 APOEε4 carrier, IgA immunoglobulin A, IgA+ immunoglobulin A-positive, LB Lewy body, NC non-demented control, NFT neurofibrillary tangle, no. number, ns not significant
  3. *Significant correlation at p ≤ 0.05 level
  4. **Significant correlation at p ≤ 0.01 level
  5. ***Significant correlation at p ≤ 0.001 level