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Table 3 Correlations between the plasma IgA levels and cognition, CRP, and CSF AD biomarkers in cohort I

From: Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Variables

All groups

NC

AD

−APOEε4

+APOEε4

MMSE (score)

ns

ns

ns

− 0.499**

ns

AQT (score)

ns

ns

ns

0.438*

ns

CRP (mg/l)

ns

ns

ns

0.534**

ns

CSF Aβ40 (pg/ml)

− 0.246*

ns

ns

− 0.390*

ns

CSF Aβ42 (pg/ml)

− 0.349**

− 0.393*

ns

− 0.582***

ns

CSF Aβ42/40

− 0.268*

ns

ns

− 0.472**

ns

  1. Data were analysed using Spearman’s correlation test
  2. Aβ amyloid beta, AD Alzheimer’s disease, APOE4 apolipoprotein 4, −APOEε4 APOEε4 non-carrier, +APOEε4 APOEε4 carrier, AQT A Quick Test, CRP C-reactive protein, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination, NC non-demented control, ns not significant
  3. *Significant correlation at p ≤ 0.05 level
  4. **Significant correlation at p ≤ 0.01 level
  5. ***Significant correlation at p ≤ 0.001 level
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Alzheimer's Research & Therapy

ISSN: 1758-9193