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Table 3 Correlations between the plasma IgA levels and cognition, CRP, and CSF AD biomarkers in cohort I

From: Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Variables All groups NC AD APOEε4 +APOEε4
MMSE (score) ns ns ns − 0.499** ns
AQT (score) ns ns ns 0.438* ns
CRP (mg/l) ns ns ns 0.534** ns
CSF Aβ40 (pg/ml) − 0.246* ns ns − 0.390* ns
CSF Aβ42 (pg/ml) − 0.349** − 0.393* ns − 0.582*** ns
CSF Aβ42/40 − 0.268* ns ns − 0.472** ns
  1. Data were analysed using Spearman’s correlation test
  2. amyloid beta, AD Alzheimer’s disease, APOE4 apolipoprotein 4, −APOEε4 APOEε4 non-carrier, +APOEε4 APOEε4 carrier, AQT A Quick Test, CRP C-reactive protein, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination, NC non-demented control, ns not significant
  3. *Significant correlation at p ≤ 0.05 level
  4. **Significant correlation at p ≤ 0.01 level
  5. ***Significant correlation at p ≤ 0.001 level