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Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants

Alzheimer's Research & Therapy volume 13, Article number: 156 (2021) Cite this article

The Original Article was published on 17 August 2021

Correction to: Alz Res Therapy 13, 140 (2021)

https://doi.org/10.1186/s13195-021-00884-7

Following the publication of the original article [1] the authors noticed that the published Fig. 3 is incorrect. The original article [1] has been updated.

Below is the correct Fig. 3.

Fig. 3
figure 1

Modelling APOE separately, assuming the same effect of APOE-ε4 (OR ~ 3) in all age groups, and accounting for age related differences in frequency of APOE-ε4 allele (MAF = 0.18 in 55+ and MAF = 0.05 in 85+). In age group 65+ (left) the presence of APOE-ɛ4 allele increases the AD probability from 0.01 to 0.07 when PRS is the lowest and from 0.2 to 0.66 when the PRS is highest (top vs bottom lines). For 85+ age group (right), these values are 0.06 to 0.3 (low PRS) and 0.65 to 0.92 (high PRS)

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Reference

  1. Escott-Price V, Schmidt KM. Probability of Alzheimer’s disease based on common and rare genetic variants. Alz Res Therapy. 2021;13(1):140. https://doi.org/10.1186/s13195-021-00884-7.

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Authors and Affiliations

  1. Dementia Research Institute, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Hadyn Ellis Building, Maindy Rd, Cardiff, CF24 4HQ, UK

    Valentina Escott-Price

  2. School of Mathematics, Cardiff University, Senghennydd Road, Cardiff, CF24 4AG, UK

    Karl Michael Schmidt

Authors
  1. Valentina Escott-Price
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  2. Karl Michael Schmidt
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Correspondence to Valentina Escott-Price.

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Escott-Price, V., Schmidt, K.M. Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants. Alz Res Therapy 13, 156 (2021). https://doi.org/10.1186/s13195-021-00898-1

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  • DOI: https://doi.org/10.1186/s13195-021-00898-1

Alzheimer's Research & Therapy

ISSN: 1758-9193