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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

Fig. 5

CLR01 treatment reduces hyperphosphorylated tau in the hippocampus of P301S-tau mice. Brain sections from P301S-tau mice were stained with monoclonal antibody AT8 and visualized by immunofluorescence. a The typical crescent shape of the hippocampus was delineated by an operator blinded to treatment. bd Representative images of the hippocampus area of mice treated with 0 (a), 0.3 (b), or 1.0 (c) mg/kg per day CLR01. d The data were quantified as the percentage of AT8-positive area within the hippocampus area, as defined in panel a. The data are presented as mean ± SD. P values were calculated using a one-way ANOVA with post hoc Tukey test

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