Neurofilament light chain in the vitreous humor of the eye

Table 3 Association of vitreous NfL levels vs. vitreous levels of inflammatory cytokines and vascular proteins

*Protein*	*Beta*	SE	*p value* (n = 77)	*p value* (adjusting for DM)
*Pro-inflammatory cytokines*
IL1α	− 1.43	0.64	0.029	0.044
IL1β	0.59	2.14	0.783	0.846
IL6	0.23	0.11	0.045	0.057
*IL15	1.21	0.33	0.000525	0.00108
*IL16	0.86	0.22	0.00022	0.00044
IL17α	1.01	0.45	0.027	0.027
TNF-α	0.20	0.61	0.748	0.645
IFN-γ	0.32	0.30	0.291	0.289
*Anti-inflammatory cytokines*
IL4	0.83	0.60	0.17	0.20
IL10	1.22	0.67	0.07	0.053
IL13	0.73	0.55	0.19	0.29
TNFβ	0.99	1.84	0.59	0.778
*Chemokines and inflammatory proteins*
*MCP-1	0.63	0.17	0.000414	0.000337
3MIP1α	0.19	0.14	0.155	0.153
*Vascular proteins*
*VEGFR1	0.90	0.17	0.00000285	0.00000292
VEGF-human	0.23	0.10	0.027	0.046
*Vegf-C	0.33	0.07	0.0000086	0.0000139
Vegf-D	0.19	0.08	0.018	0.034
*VCAM-1	0.40	0.11	0.0005	0.0007
*Tie2	0.25	0.07	0.00063	0.0012
*ICAM-1	0.59	0.15	0.00016	0.00028
CRP	0.23	0.10	0.0265	0.0435
SAA	0.14	0.06	0.017	0.0289
bFGF	0.05	0.11	0.616	0.462

Association of NfL with inflammatory cytokines, chemokines, and vascular proteins associated with neurodegenerative disease. The proteins marked with an asterisk (*) maintain statistical significance with NfL after conducting the Bonferroni test for multiple comparisons (0.05/41 analytes with a new p = 0.0012). As diabetic patients are at higher risk for the development of AD as well as retinal damage, we sought to determine vitreous associations independent of the presence of diabetes

ISSN: 1758-9193