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Table 3 Association of vitreous NfL levels vs. vitreous levels of inflammatory cytokines and vascular proteins

From: Neurofilament light chain in the vitreous humor of the eye

Protein Beta SE p value (n = 77) p value (adjusting for DM)
Pro-inflammatory cytokines
 IL1α − 1.43 0.64 0.029 0.044
 IL1β 0.59 2.14 0.783 0.846
 IL6 0.23 0.11 0.045 0.057
 *IL15 1.21 0.33 0.000525 0.00108
 *IL16 0.86 0.22 0.00022 0.00044
 IL17α 1.01 0.45 0.027 0.027
 TNF-α 0.20 0.61 0.748 0.645
 IFN-γ 0.32 0.30 0.291 0.289
Anti-inflammatory cytokines
 IL4 0.83 0.60 0.17 0.20
 IL10 1.22 0.67 0.07 0.053
 IL13 0.73 0.55 0.19 0.29
 TNFβ 0.99 1.84 0.59 0.778
Chemokines and inflammatory proteins
 *MCP-1 0.63 0.17 0.000414 0.000337
 3MIP1α 0.19 0.14 0.155 0.153
Vascular proteins
 *VEGFR1 0.90 0.17 0.00000285 0.00000292
 VEGF-human 0.23 0.10 0.027 0.046
 *Vegf-C 0.33 0.07 0.0000086 0.0000139
 Vegf-D 0.19 0.08 0.018 0.034
 *VCAM-1 0.40 0.11 0.0005 0.0007
 *Tie2 0.25 0.07 0.00063 0.0012
 *ICAM-1 0.59 0.15 0.00016 0.00028
 CRP 0.23 0.10 0.0265 0.0435
 SAA 0.14 0.06 0.017 0.0289
 bFGF 0.05 0.11 0.616 0.462
  1. Association of NfL with inflammatory cytokines, chemokines, and vascular proteins associated with neurodegenerative disease. The proteins marked with an asterisk (*) maintain statistical significance with NfL after conducting the Bonferroni test for multiple comparisons (0.05/41 analytes with a new p = 0.0012). As diabetic patients are at higher risk for the development of AD as well as retinal damage, we sought to determine vitreous associations independent of the presence of diabetes