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Table 5 Association of single or combined medications with the development of dementia with possible AD after TBI occurrence

From: Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer’s disease after traumatic brain injury

Medicationp valueHazard ratio95%CI
Age<.00011.111.101.13
Sex0.950.990.591.63
Black0.510.880.611.28
Hispanic<.00011.951.442.64
Other0.870.940.442.00
ACEI0.010.590.400.89
Beta blocker<.00010.390.250.60
Metformin0.210.740.461.19
Statins0.080.730.511.04
ACEI + beta0.080.590.331.07
ACEI + statin0.0050.410.230.76
ACEI + metformin0.020.180.040.75
Beta blocker + statin0.020.540.320.91
Beta blocker + metformin0.140.410.121.33
Statin + metformin0.911.040.532.02
Medication duration0.131.001.001.00
Sleep0.860.970.651.43
Thyroid0.600.890.581.37
Cardiac dysrhythmia0.041.421.021.97
Cancer0.070.690.461.04
Congestive heart failure0.030.540.300.95
Coronary artery disease0.991.000.741.36
Diabetes0.471.120.831.50
Hyperlipidemia0.111.240.961.61
Hypertension0.321.150.871.51
Kidney0.050.470.221.01
Liver0.351.390.702.78
Lung0.470.900.691.19
Peripheral artery disease0.450.860.571.28
Stroke0.850.970.681.37
Alcohol0.861.030.731.45
Anxiety0.091.290.961.72
Bipolar0.881.030.691.55
PTSD0.380.860.621.20
Schizophrenia0.711.100.661.85
Depression0.031.331.021.73
Drug substance0.230.750.461.20
Number of TBI occurrence0.00021.041.021.06
  1. Note: Duration is the summation of total day supply of single or both medications