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Table 1 Demographic and clinical data of genotypic groups

From: ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease

  G-allele-carriers P value TT-carriers P value
ε4+ carriers ε4 non-carriers ε4+ carriers ε4 non-carriers
Sample size (n) 61 99   40 87  
Age (years) 72.8 ± 7.4 72.8 ± 7.7 0.945 72.3 ± 8.1 71.7 ± 9.1 0.689
Sex (female/male) 34/27 58/41 0.723 23/17 39/48 0.184
Education (years) 7.1 ± 4.6 7.0 ± 4.7 0.970 6.2 ± 5.4 8.0 ± 5.4 0.092
MMSE scores 18.6 ± 6.2 21.1 ± 7.1 0.023 20.0 ± 7.0 20.4 ± 7.2 0.735
Mean symptom duration (years) 2.5 ± 1.4 2.4 ± 1.2 0.686 2.4 ± 1.3 2.5 ± 1.0 0.676
Therapy affecting the default mode network
 Sedatives (n, %) 9, 14.8% 12, 12.1% 0.632 6, 15% 21, 24.1% 0.242
Memory scores
 CVVLT-30 sec 3.7 ± 2.6 5.0 ± 2.9 0.006 4.5 ± 3.0 5.1 ± 2.6 0.275
 CVVLT-10 min 2.1 ± 2.9 4.6 ± 3.3 < 0.001 3.5 ± 3.5 4.3 ± 3.0 0.206
 CVVLT-cued 3.0 ± 2.9 5.0 ± 2.8 < 0.001 4.1 ± 3.0 4.6 ± 2.8 0.388
Visuospatial function: mROCF-copy 13.8 ± 5.4 13.8 ± 5.2 0.950 13.4 ± 5.5 13.8 ± 5.2 0.675
Executive function scores: TMB (seconds) 105.2 ± 30.2 94.9 ± 35.1 0.061 95.1 ± 36.2 96.1 ± 32.3 0.868
  1. Data are presented as mean ± standard deviation; P values denote significant differences between ε4+ and ε4− carriers in independent t tests for continuous variables and χ2 tests for dichotomous variables. CVVLT Chinese version of the Verbal Learning Test, CVVLT-30 sec recall after a 30-s interval, CVVLT-10 min recall after a 10-min delay, CVVLT-cued recall after a cue, ε4+ carriers APOE-ε4 carriers, ε4 non-carriers APOE-ε4 non-carriers, G-allele-carriers ABCA7 rs3764650G allele carriers, MMSE Mini-Mental State Examination, mROCF-copy modified Rey-Osterrieth Complex Figure Copy test, TMB Trail Making Test B, TT-carriers ABCA7 rs3764650T homozygous carriers