ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease

Table 1 Demographic and clinical data of genotypic groups

	G-allele-carriers		P value	TT-carriers		P value
	ε4+ carriers	ε4 non-carriers	P value	ε4+ carriers	ε4 non-carriers	P value
Sample size (n)	61	99		40	87
Age (years)	72.8 ± 7.4	72.8 ± 7.7	0.945	72.3 ± 8.1	71.7 ± 9.1	0.689
Sex (female/male)	34/27	58/41	0.723	23/17	39/48	0.184
Education (years)	7.1 ± 4.6	7.0 ± 4.7	0.970	6.2 ± 5.4	8.0 ± 5.4	0.092
MMSE scores	18.6 ± 6.2	21.1 ± 7.1	0.023	20.0 ± 7.0	20.4 ± 7.2	0.735
Mean symptom duration (years)	2.5 ± 1.4	2.4 ± 1.2	0.686	2.4 ± 1.3	2.5 ± 1.0	0.676
Therapy affecting the default mode network
Sedatives (n, %)	9, 14.8%	12, 12.1%	0.632	6, 15%	21, 24.1%	0.242
Memory scores
CVVLT-30 sec	3.7 ± 2.6	5.0 ± 2.9	0.006	4.5 ± 3.0	5.1 ± 2.6	0.275
CVVLT-10 min	2.1 ± 2.9	4.6 ± 3.3	< 0.001	3.5 ± 3.5	4.3 ± 3.0	0.206
CVVLT-cued	3.0 ± 2.9	5.0 ± 2.8	< 0.001	4.1 ± 3.0	4.6 ± 2.8	0.388
Visuospatial function: mROCF-copy	13.8 ± 5.4	13.8 ± 5.2	0.950	13.4 ± 5.5	13.8 ± 5.2	0.675
Executive function scores: TMB (seconds)	105.2 ± 30.2	94.9 ± 35.1	0.061	95.1 ± 36.2	96.1 ± 32.3	0.868

Data are presented as mean ± standard deviation; P values denote significant differences between ε4+ and ε4− carriers in independent t tests for continuous variables and χ² tests for dichotomous variables. CVVLT Chinese version of the Verbal Learning Test, CVVLT-30 sec recall after a 30-s interval, CVVLT-10 min recall after a 10-min delay, CVVLT-cued recall after a cue, ε4+ carriers APOE-ε4 carriers, ε4 non-carriers APOE-ε4 non-carriers, G-allele-carriers ABCA7 rs3764650G allele carriers, MMSE Mini-Mental State Examination, mROCF-copy modified Rey-Osterrieth Complex Figure Copy test, TMB Trail Making Test B, TT-carriers ABCA7 rs3764650T homozygous carriers

ISSN: 1758-9193