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Table 5 Association of haemoglobin levels with cognition

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease) Global cognition Domain specific cognitive performance
β (95% CI)a Executive
β (95% CI)a
Attention
β (95% CI)a
Language
β (95% CI)a
Verbal Memory
β (95% CI)a
Visual Memory
β (95% CI)a
Visuoconstruction
β (95% CI)a
Visuomotor speed
β (95% CI)a
Model I −0.05 (− 0.10, − 0.01) −0.06 (− 0.11, − 0.01) −0.05 (− 0.09, 0.00) −0.07 (− 0.12, − 0.02) −0.02 (− 0.06, 0.03) −0.05 (− 0.09, 0.00) −0.04 (− 0.09, 0.00) −0.04 (− 0.08, 0.00)
p = 0.011 p = 0.017 p = 0.041 p = 0.007 p = 0.457 p = 0.039 p = 0.055 p = 0.069
Model II −0.06 (−0.10, − 0.01) −0.06 (− 0.11, − 0.01) −0.06 (− 0.11, − 0.01) −0.07 (− 0.12, − 0.02) −0.01 (− 0.06, 0.04) −0.05 (− 0.10, 0.00) −0.04 (− 0.09, 0.01) −0.03 (− 0.08, 0.01)
p = 0.014 p = 0.020 p = 0.014 p = 0.012 p = 0.666 p = 0.063 p = 0.081 p = 0.132
Model III −0.04 (−0.09, 0.00) −0.05 (− 0.10, 0.01) −0.05 (− 0.10, − 0.01) −0.06 (− 0.12, 0.00) −0.01 (− 0.06, 0.05) −0.04 (− 0.09, 0.01) −0.03 (− 0.08, 0.02) −0.03 (− 0.07, 0.02)
p = 0.048 p = 0.078 p = 0.028 p = 0.048 p = 0.395 p = 0.143 p = 0.176 p = 0.217
  1. Hb Haemoglobin
  2. Model I: adjusted for age, gender, race, education and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
  4. Model III: Model II + socio-economic status + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarct)
  5. aThe reported CIs and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
  6. None of the associations reached revised statistical significance (Bonferroni-corrected p = 0.0071)