Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Table 4 Association of haemoglobin with subcortical structure volumes

Hb (per g/dl decrease)	Accumbens (ml), β (95% CI)^a	Amygdala (ml), β (95% CI)^a	Caudate (ml), β (95% CI)^a	Pallidum (ml), β (95% CI)^a	Putamen (ml), β (95% CI)^a	Thalamus (ml), β (95% CI)^a	Hippocampus (ml), β (95% CI)^a	Brainstem (ml), β (95% CI)^a
Model I	− 0.02 (− 0.03, − 0.01)	−0.02 (− 0.04, 0.00)	−0.03 (− 0.08, 0.02)	−0.01 (− 0.04, 0.01)	−0.08 (− 0.14, − 0.01)	−0.03 (− 0.09, 0.02)	−0.04 (− 0.08, 0.01)	−0.15 (− 0.27, − 0.03)
Model I	p < 0.001	p = 0.055	p = 0.291	p = 0.233	p = 0.019	p = 0.245	p = 0.097	p = 0.014
Model II	−0.02 (− 0.03, − 0.01)	−0.02 (− 0.04, 0.01)	0.00 (− 0.06, 0.05)	0.00 (− 0.03, 0.02)	−0.05 (− 0.11, 0.02)	−0.01 (− 0.06, 0.07)	−0.02 (− 0.07, 0.02)	−0.07 (− 0.20, 0.06)
Model II	p = 0.001	p = 0.134	p = 0.899	p = 0.833	p = 0.190	p = 0.870	p = 0.366	p = 0.312
Model III	−0.01 (−0.02, 0.00)	−0.01 (− 0.04, 0.01)	−0.02 (− 0.07, 0.03)	0.00 (− 0.02, 0.02)	−0.05 (− 0.12, 0.02)	0.01 (− 0.04, 0.07)	−0.02 (− 0.06, 0.03)	−/0.04 (− 0.16, 0.08)
Model III	p = 0.005^b	p = 0.215	p = 0.493	p = 0.912	p = 0.169	p = 0.629	p = 0.433	p = 0.551

Hb Haemoglobin
Model I: adjusted for age, gender, race and smoking status
Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)
^aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
^bSignificant after Bonferroni correction p = 0.00625

ISSN: 1758-9193