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Table 4 Association of haemoglobin with subcortical structure volumes

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease) Accumbens (ml),
β (95% CI)a
Amygdala (ml),
β (95% CI)a
Caudate (ml),
β (95% CI)a
Pallidum (ml),
β (95% CI)a
Putamen (ml),
β (95% CI)a
Thalamus (ml),
β (95% CI)a
Hippocampus (ml),
β (95% CI)a
Brainstem (ml),
β (95% CI)a
Model I − 0.02 (− 0.03, − 0.01) −0.02 (− 0.04, 0.00) −0.03 (− 0.08, 0.02) −0.01 (− 0.04, 0.01) −0.08 (− 0.14, − 0.01) −0.03 (− 0.09, 0.02) −0.04 (− 0.08, 0.01) −0.15 (− 0.27, − 0.03)
p < 0.001 p = 0.055 p = 0.291 p = 0.233 p = 0.019 p = 0.245 p = 0.097 p = 0.014
Model II −0.02 (− 0.03, − 0.01) −0.02 (− 0.04, 0.01) 0.00 (− 0.06, 0.05) 0.00 (− 0.03, 0.02) −0.05 (− 0.11, 0.02) −0.01 (− 0.06, 0.07) −0.02 (− 0.07, 0.02) −0.07 (− 0.20, 0.06)
p = 0.001 p = 0.134 p = 0.899 p = 0.833 p = 0.190 p = 0.870 p = 0.366 p = 0.312
Model III −0.01 (−0.02, 0.00) −0.01 (− 0.04, 0.01) −0.02 (− 0.07, 0.03) 0.00 (− 0.02, 0.02) −0.05 (− 0.12, 0.02) 0.01 (− 0.04, 0.07) −0.02 (− 0.06, 0.03) −/0.04 (− 0.16, 0.08)
p = 0.005b p = 0.215 p = 0.493 p = 0.912 p = 0.169 p = 0.629 p = 0.433 p = 0.551
  1. Hb Haemoglobin
  2. Model I: adjusted for age, gender, race and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
  4. Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)
  5. aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
  6. bSignificant after Bonferroni correction p = 0.00625