Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer’s disease. Lancet. 2011;377(9770):1019–31.
Article
PubMed
Google Scholar
Burns A, Iliffe S. Alzheimer’s disease. BMJ. 2009;338:b158.
Article
PubMed
Google Scholar
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128.
Article
PubMed
Google Scholar
Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol. 2014;88(4):640–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer’s disease and neuronal loss. Hippocampus. 2015;25(7):813–26.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012;367(9):795–804.
Article
CAS
PubMed
PubMed Central
Google Scholar
Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Schneider LS, et al. Advances in the prevention of Alzheimer’s disease and dementia. J Intern Med. 2014;275(3):229–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ryu JK, Cho T, Choi HB, Jantaratnotai N, McLarnon JG. Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease. J Neuroinflammation. 2015;12:144.
Article
PubMed
PubMed Central
Google Scholar
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012;79(3):221–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014;71(11):1394–404.
Article
PubMed
PubMed Central
Google Scholar
Cabral C, Morgado PM, Campos Costa D, Silveira M. Alzheimers Disease Neuroimaging Initiative. Predicting conversion from MCI to AD with FDG-PET brain images at different prodromal stages. Comput Biol Med. 2015;58:101–9.
Article
PubMed
Google Scholar
Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63(2):168–74.
Article
PubMed
Google Scholar
Ertekin-Taner N. Genetics of Alzheimer disease in the pre- and post-GWAS era. Alzheimers Res Ther. 2010;2(1):3.
Article
PubMed
PubMed Central
Google Scholar
Zhang B, Kirov S, Snoddy J. WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 2005;33(Web Server issue):W741–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Bardes EE, Aronow BJ, Jegga AG. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 2009;37(Web Server issue):W305–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cowley MJ, Pinese M, Kassahn KS, Waddell N, Pearson JV, Grimmond SM, Biankin AV, Hautaniemi S, Wu J. PINA v2.0: mining interactome modules. Nucleic Acids Res. 2012;40(Database issue):D862–5.
Article
CAS
PubMed
Google Scholar
Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabasi AL. Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science. 2015;347(6224):1257601.
Article
PubMed
PubMed Central
Google Scholar
Barabasi AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12(1):56–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Klein P, Ravi R. A nearly best-possible approximation algorithm for node-weighted Steiner trees. J Algorithms. 1995;19(1):104–15.
Article
Google Scholar
Zheng S, Zhao Z. GenRev: exploring functional relevance of genes in molecular networks. Genomics. 2012;99(3):183–8.
Article
CAS
PubMed
Google Scholar
Erdos P, Rényi A. On the evolution of random graphs. Publ Math Inst Hungar Acad Sci. 1960;5:17–61.
Google Scholar
Roussotte FF, Daianu M, Jahanshad N, Leonardo CD, Thompson PM. Neuroimaging and genetic risk for Alzheimer’s disease and addiction-related degenerative brain disorders. Brain Imaging Behav. 2014;8(2):217–33.
Article
PubMed
PubMed Central
Google Scholar
Anstey KJ, Mack HA, Cherbuin N. Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. Am J Geriatr Psychiatry. 2009;17(7):542–55.
Article
PubMed
Google Scholar
Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, Kellis M. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature. 2015;518(7539):365–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer’s disease. Nat Immunol. 2015;16(3):229–36.
Article
CAS
PubMed
Google Scholar
Wang C, Zhang X, Teng Z, Zhang T, Li Y. Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice. Eur J Pharmacol. 2014;740:312–20.
Article
CAS
PubMed
Google Scholar
Polychronidou E, Vlachakis D, Vlamos P, Baumann M, Kossida S. Notch signaling and ageing. Adv Exp Med Biol. 2015;822:25–36.
Article
PubMed
Google Scholar
Wang D, Ho L, Faith J, Ono K, Janle EM, Lachcik PJ, Cooper BR, Jannasch AH, D’Arcy BR, Williams BA, et al. Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer’s disease beta-amyloid oligomerization. Mol Nutr Food Res. 2015;59(6):1025–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alam MZ, Alam Q, Kamal MA, Abuzenadah AM, Haque A. A possible link of gut microbiota alteration in type 2 diabetes and Alzheimer’s disease pathogenicity: an update. CNS Neurol Disord Drug Targets. 2014;13(3):383–90.
Article
CAS
PubMed
Google Scholar
Roos PM. Osteoporosis in neurodegeneration. J Trace Elem Med Biol. 2014;28(4):418–21.
Article
CAS
PubMed
Google Scholar
Letra L, Santana I, Seica R. Obesity as a risk factor for Alzheimer’s disease: the role of adipocytokines. Metab Brain Dis. 2014;29(3):563–8.
Article
CAS
PubMed
Google Scholar
Teixeira AL, Diniz BS, Campos AC, Miranda AS, Rocha NP, Talib LL, Gattaz WF, Forlenza OV. Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer’s disease. Neruomol Med. 2013;15(1):115–21.
Article
CAS
Google Scholar
Jia P, Kao CF, Kuo PH, Zhao Z. A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol. 2011;5 Suppl 3:S12.
Article
PubMed
PubMed Central
Google Scholar
Leal MC, Magnani N, Villordo S, Buslje CM, Evelson P, Castano EM, Morelli L. Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid beta (Abeta) peptide catabolism and functionality. J Biol Chem. 2013;288(18):12920–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Conejero-Goldberg C, Hyde TM, Chen S, Dreses-Werringloer U, Herman MM, Kleinman JE, Davies P, Goldberg TE. Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer’s disease as based on APOE genotype. Mol Psychiatry. 2011;16(8):836–47.
Article
CAS
PubMed
Google Scholar
Adori C, Gluck L, Barde S, Yoshitake T, Kovacs GG, Mulder J, Magloczky Z, Havas L, Bolcskei K, Mitsios N, et al. Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease. Acta Neuropathol. 2015;129(4):541–63.
Article
CAS
PubMed
Google Scholar
Capsoni S, Amato G, Vignone D, Criscuolo C, Nykjaer A, Cattaneo A. Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation. Biochem Biophys Res Commun. 2013;431(3):579–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem. 2015;290(40):24152–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Inkster B, Rao AW, Ridler K, Filippini N, Whitcher B, Nichols TE, Wetten S, Gibson RA, Borrie M, Kertesz A, et al. Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer’s disease. Neurobiol Aging. 2012;33(3):457–65.
Article
CAS
PubMed
Google Scholar
Raha AA, Vaishnav RA, Friedland RP, Bomford A, Raha-Chowdhury R. The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease. Acta Neuropathol Commun. 2013;1:55.
Article
PubMed
PubMed Central
Google Scholar
Kong W, Zhang J, Mou X, Yang Y. Integrating gene expression and protein interaction data for signaling pathway prediction of Alzheimer’s disease. Comput Math Methods Med. 2014;2014:340758.
PubMed
PubMed Central
Google Scholar
Ponzoni I, Nueda M, Tarazona S, Gotz S, Montaner D, Dussaut J, Dopazo J, Conesa A. Pathway network inference from gene expression data. BMC Syst Biol. 2014;8 Suppl 2:S7.
Article
PubMed
PubMed Central
Google Scholar
Sun Y, Bresell A, Rantalainen M, Hoglund K, Lebouvier T, Salter H. Alzheimer Disease Neuroimaging Initiative. An integrated bioinformatics approach for identifying genetic markers that predict cerebrospinal fluid biomarker p-tau181/Abeta1-42 ratio in ApoE4-negative mild cognitive impairment patients. J Alzheimers Dis. 2015;45(4):1061–76.
CAS
PubMed
Google Scholar
Williams-Skipp C, Raman T, Valuck RJ, Watkins H, Palmer BE, Scheinman RI. Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum. 2009;60(2):408–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Parra MA, Saarimaki H, Bastin ME, Londono AC, Pettit L, Lopera F, Della Sala S, Abrahams S. Memory binding and white matter integrity in familial Alzheimer’s disease. Brain. 2015;138(Pt 5):1355–69.
Article
PubMed
Google Scholar
Ahmadian-Attari MM, Dargahi L, Mosaddegh M, Kamalinejad M, Khallaghi B, Noorbala F, Ahmadiani A. Impairment of rat spatial learning and memory in a new model of cold water-induced chronic hypothermia: implication for Alzheimer’s disease. Neurotox Res. 2015;28(2):95–107.
Article
CAS
PubMed
Google Scholar
Peter-Derex L, Yammine P, Bastuji H, Croisile B. Sleep and Alzheimer’s disease. Sleep Med Rev. 2015;19:29–38.
Article
PubMed
Google Scholar
Suzuki C, Yokote Y, Takahashi T. Changes in daily cognition and behavior of Alzheimer’s patients over time: a three-year evaluation using a daily cognition and behavior for Alzheimer’s disease scale. Dementia. 2015;14(1):126–35.
Article
PubMed
Google Scholar
Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer’s disease brains. Neuropathol Appl Neurobiol. 2013;39(2):109–20.
Article
CAS
PubMed
Google Scholar
Landlinger C, Oberleitner L, Gruber P, Noiges B, Yatsyk K, Santic R, Mandler M, Staffler G. Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer’s disease. J Neuroinflammation. 2015;12:150.
Article
PubMed
PubMed Central
Google Scholar
Alcolea D, Martinez-Lage P, Sanchez-Juan P, Olazaran J, Antunez C, Izagirre A, Ecay-Torres M, Estanga A, Clerigue M, Guisasola MC, et al. Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease. Neurology. 2015;85(7):626–33.
Article
CAS
PubMed
Google Scholar
Wang X, Hu X, Yang Y, Takata T, Sakurai T. Systemic pyruvate administration markedly reduces neuronal death and cognitive impairment in a rat model of Alzheimer’s disease. Exp Neurol. 2015;271:145–54.
Article
CAS
PubMed
Google Scholar
Ahmed T, Blum D, Burnouf S, Demeyer D, Buee-Scherrer V, D’Hooge R, Buee L, Balschun D. Rescue of impaired late-phase long-term depression in a tau transgenic mouse model. Neurobiol Aging. 2015;36(2):730–9.
Article
CAS
PubMed
Google Scholar
Koch G, Di Lorenzo F, Bonni S, Ponzo V, Caltagirone C, Martorana A. Impaired LTP- but not LTD-like cortical plasticity in Alzheimer’s disease patients. J Alzheimers Dis. 2012;31(3):593–9.
CAS
PubMed
Google Scholar
Bethea CL, Reddy AP. Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Mol Psychiatry. 2015;20(12):1565–78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Folch J, Patraca I, Martinez N, Pedros I, Petrov D, Ettcheto M, Abad S, Marin M, Beas-Zarate C, Camins A. The role of leptin in the sporadic form of Alzheimer’s disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin. Life Sci. 2015;140:19–28.
Article
CAS
PubMed
Google Scholar
Magalhaes CA, Carvalho MG, Sousa LP, Caramelli P, Gomes KB. Leptin in Alzheimer’s disease. Clin Chim Acta. 2015;450:162–8.
Article
CAS
PubMed
Google Scholar
de la Monte SM, Tong M. Brain metabolic dysfunction at the core of Alzheimer’s disease. Biochem Pharmacol. 2014;88(4):548–59.
Article
PubMed
Google Scholar
Merlo S, Spampinato S, Canonico PL, Copani A, Sortino MA. Alzheimer’s disease: brain expression of a metabolic disorder? Trends Endocrinol Metab. 2010;21(9):537–44.
Article
CAS
PubMed
Google Scholar
Demetrius LA, Driver J. Alzheimer’s as a metabolic disease. Biogerontology. 2013;14(6):641–9.
Article
CAS
PubMed
Google Scholar
Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ. Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer’s disease. Biol Psychiatry. 2015;77(8):693–703.
Article
CAS
PubMed
Google Scholar
Potter PE, Rauschkolb PK, Pandya Y, Sue LI, Sabbagh MN, Walker DG, Beach TG. Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer’s disease. Acta Neuropathol. 2011;122(1):49–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pimenova AA, Thathiah A, De Strooper B, Tesseur I. Regulation of amyloid precursor protein processing by serotonin signaling. PLoS One. 2014;9(1):e87014.
Article
PubMed
PubMed Central
Google Scholar
Egorova P, Popugaeva E, Bezprozvanny I. Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer’s disease. Semin Cell Dev Biol. 2015;40:127–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scheperjans F. Can microbiota research change our understanding of neurodegenerative diseases? Neurodegener Dis Manag. 2016;6(2):81–5.
Article
PubMed
Google Scholar
Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther. 2016;158:52–62.
Article
CAS
PubMed
Google Scholar
Catanzaro R, Anzalone M, Calabrese F, Milazzo M, Capuana M, Italia A, Occhipinti S, Marotta F. The gut microbiota and its correlations with the central nervous system disorders. Panminerva Med. 2015;57(3):127–43.
CAS
PubMed
Google Scholar
Pedros I, Petrov D, Allgaier M, Sureda F, Barroso E, Beas-Zarate C, Auladell C, Pallas M, Vazquez-Carrera M, Casadesus G, et al. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer’s disease. Biochim Biophys Acta. 2014;1842(9):1556–66.
Article
CAS
PubMed
Google Scholar
Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013;153(3):707–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer’s disease. Mol Psychiatry. 2014;19(6):676–81.
Article
CAS
PubMed
Google Scholar
Atkin G, Hunt J, Minakawa E, Sharkey L, Tipper N, Tennant W, Paulson HL. F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. J Biol Chem. 2014;289(10):7038–48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, et al. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006;125(4):801–14.
Article
CAS
PubMed
Google Scholar
Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, et al. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. FASEB J. 2011;25(6):1983–2000.
Article
CAS
PubMed
Google Scholar
Matsuoka M. Protective effects of Humanin and calmodulin-like skin protein in Alzheimer’s disease and broad range of abnormalities. Mol Neurobiol. 2015;51(3):1232–9.
Article
CAS
PubMed
Google Scholar
Chai GS, Duan DX, Ma RH, Shen JY, Li HL, Ma ZW, Luo Y, Wang L, Qi XH, Wang Q, et al. Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid beta-peptide in rats. Neurosci Bull. 2014;30(6):923–35.
Article
CAS
PubMed
Google Scholar
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007;39(1):17–23.
Article
CAS
PubMed
Google Scholar
Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, et al. Alzheimer’s Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement. 2010;6(3):265–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cruts M, Theuns J, Van Broeckhoven C. Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat. 2012;33(9):1340–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bai Z, Han G, Xie B, Wang J, Song F, Peng X, Lei H. AlzBase: an integrative database for gene dysregulation in Alzheimer’s disease. Mol Neurobiol. 2016;53(1):310–9.
Article
CAS
PubMed
Google Scholar
Roncaglia P, Martone ME, Hill DP, Berardini TZ, Foulger RE, Imam FT, Drabkin H, Mungall CJ, Lomax J. The Gene Ontology (GO) cellular component ontology: integration with SAO (Subcellular Anatomy Ontology) and other recent developments. J Biomed Semantics. 2013;4(1):20.
Article
PubMed
PubMed Central
Google Scholar
Ideker T, Sharan R. Protein networks in disease. Genome Res. 2008;18(4):644–52.
Article
CAS
PubMed
PubMed Central
Google Scholar