DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

Table 2 Regional DHA k* by APOE subgroup (μl∙minute⁻¹∙ml⁻¹)

Regions	APOE4 noncarriers (n = 13)	APOE4 carriers (n = 9)	p Value	Adjusted p value^a
Orbitofrontal	4.84 (1.25)	5.20 (0.59)	0.42	0.79
Prefrontal	3.81 (0.76)	4.37 (0.56)	0.07	0.12
Premotor	3.86 (0.73)	4.65 (0.51)	0.01	0.057
Anterior cingulate	2.76 (0.55)	3.27 (0.31)	0.02	0.088
Inferior temporal	3.56 (0.87)	3.96 (0.37)	0.21	0.56
Middle temporal	3.72 (0.83)	4.11 (0.39)	0.21	0.57
Superior temporal	3.42 (0.88)	3.69 (0.50)	0.41	0.87
Medial temporal	2.16 (0.45)	2.53 (0.33)	0.046	0.28
Sensorimotor	3.95 (0.84)	4.78 (0.52)	0.016	0.12
Inferior parietal	3.89 (0.87)	4.42 (0.46)	0.26	0.40
Superior parietal	4.38 (1.09)	4.81 (0.35)	0.26	0.59
Medial parietal	3.55 (0.88)	4.35 (0.38)	0.018	0.087
Posterior cingulate	3.09 (0.71)	4.00 (0.34)	0.002	0.02
Occipital association	3.98 (0.86)	4.81 (0.47)	0.016	0.12
Calcarine	4.41 (1.01)	5.07 (0.64)	0.098	0.35
Thalamus	3.90 (0.99)	4.62 (0.43)	0.053	0.06
Striatum	3.57 (0.95)	4.16 (0.84)	0.149	0.11
Cerebellar hemisphere	3.30 (0.82)	3.91 (0.53)	0.141	0.29
Vermis	2.97 (0.81)	3.60 (0.50)	0.051	0.046
Pure white matter	1.09 (0.41)	1.26 (0.16)	0.25	0.21
Average gray matter	3.64 (0.75)	4.23 (0.37)	0.04	0.19

APOE4 Apolipoprotein E ɛ4
Data are presented as mean (SD). Docosahexaenoic acid k* values were partial volume error-corrected. Groups were compared using a linear regression model. Significantly differences (p < 0.05) by APOE group are shown in bold type
^a Adjusted to age and sex

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