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Table 5 CSF and corresponding serum concentrations and CSF: serum ratios

From: Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

  BAN2401 levels 24 h after final dose BAN2401 levels 10-14 days after final dose
Cohort (dose mg/kg) CSF (ng/mL) Serum (μg/mL) CSF:serum Ratio CSF (ng/mL) Serum (μg/mL) CSF:serum ratio
SAD6 (15) 96.3 (45.1) 265 (63.1) 0.04 % (0.03 %) 72.2, 624a 104 (31.3) 0.07 %, 0.81%a
MAD1 (0.3) 3.47 (2.1) 4.85 (1.3) 0.08 % (0.05 %) CSF not collected
MAD2 (1) 8.89 (5.31) 17.6 (1.05) 0.04 % (0.03 %)
MAD3 (3) 25.0 (13.3) 44.1 (4.55) 0.06 % (0.04 %)
MAD4 (10) 263 (106) 211 (46.0) 0.13 % (0.03 %) 116 (109) 37.5 (21.8) 0.29 % (0.14 %)
  1. Values are expressed as mean and (SD)
  2. CSF cerebrospinal fluid, SAD single ascending dose, MAD multiple ascending dose
  3. aIndividual values are shown because n = 2