Cohort | n | Dose (mg/kg) | Cmax (μg/mL) | AUC(0-24) (μg*h/mL) | AUC(0-inf) (μg*h/mL) | t1/2 (h) |
---|---|---|---|---|---|---|
SAD1 | 6 | 0.1 | NC | NC | NC | NC |
SAD2 | 6 | 0.3 | 8.50 (2.4) | NC | NC | NC |
SAD3 | 6 | 1 | 24.7 (3.6) | NC | NC | NC |
SAD4 | 6 | 3 | 74.2 (11) | 1390 (140) | 7430 (1210) | NC |
SAD5 | 6 | 10 | 264 (32.4) | 5010 (550) | 38000 (7340) | 165 (45.5) |
SAD6 | 6 | 15 | 418 (54.5) | 7630 (593) | 66900 (17600) | 174 (36.1) |
MAD1 | 6 | 0.3 | 7.26 (1.5) | 133 (23) | NA | NC |
MAD2 | 3 | 1 | 30.6 (4.6) | 470 (110) | NA | NC |
MAD3 | 5 | 3 | 68.8 (9) | 1220 (132) | NA | NC |
MAD4 | 6 | 10 | 307 (70.2) | 5720(1230) | NA | 127(30) |