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Table 4 Pharmacokinetic parameters of BAN2401

From: Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

Cohort n Dose (mg/kg) Cmax (μg/mL) AUC(0-24) (μg*h/mL) AUC(0-inf) (μg*h/mL) t1/2 (h)
SAD1 6 0.1 NC NC NC NC
SAD2 6 0.3 8.50 (2.4) NC NC NC
SAD3 6 1 24.7 (3.6) NC NC NC
SAD4 6 3 74.2 (11) 1390 (140) 7430 (1210) NC
SAD5 6 10 264 (32.4) 5010 (550) 38000 (7340) 165 (45.5)
SAD6 6 15 418 (54.5) 7630 (593) 66900 (17600) 174 (36.1)
MAD1 6 0.3 7.26 (1.5) 133 (23) NA NC
MAD2 3 1 30.6 (4.6) 470 (110) NA NC
MAD3 5 3 68.8 (9) 1220 (132) NA NC
MAD4 6 10 307 (70.2) 5720(1230) NA 127(30)
  1. PK parameters for the MAD cohorts were calculated after the final dose of BAN2401. Values reported are Mean (SD)
  2. AUC area under the curve, NC not calculated due to insufficient data, NA not applicable for dosing with multiple doses.