Table 3 Look-up of Alzheimer’s disease associated genes from KEGG pathways and their expression in hippocampus from Alzheimer’s patients (GSE48350 dataset) and rat CGC glutamate + candesartan treatment
KEGG gene symbol | Gene symbol | GSE48350 hippocampus ctrl vs AD p value | GSE48350 hippocampus ctrl vs AD fold change | CGC glutamate vs ctrl p value | CGC glutamate vs ctrl fold change | CGC glutamate vs glutamate + candesartan p value | CGC glutamate vs glutamate + candesartan fold change |
|---|---|---|---|---|---|---|---|
NMDAR | GRIN1 | 0.000 | –2.184 | 0.037 | –1.191 | 0.733 | 1.026 |
Cn | PPP3CB | 0.000 | –2.111 | 0.002 | –1.245 | 0.001 | 1.277 |
CDK5 | cdk5 | 0.000 | –2.039 | 0.357 | –1.041 | 0.436 | 1.035 |
p35 | Cdk5r1 | 0.000 | –2.031 | 0.774 | 1.040 | 0.391 | –1.126 |
Cn | ppp3ca | 0.000 | –1.749 | 0.000 | –1.221 | 0.003 | 1.158 |
SERCA | ATP2A2 | 0.000 | –1.691 | 0.002 | –1.176 | 0.001 | 1.183 |
PLC | PLCB1 | 0.000 | –1.653 | 0.038 | –1.060 | 0.000 | 1.147 |
ERK2 | MAPK1 | 0.000 | –1.578 | 0.012 | –1.074 | 0.026 | 1.063 |
CxIII | uqcrfs1 | 0.000 | –1.535 | 0.254 | 1.099 | 0.002 | 1.379 |
NOS | NOS1 | 0.000 | –1.529 | 0.403 | –1.060 | 0.38 | 1.063 |
SNCA | Snca | 0.000 | –1.472 | 0.755 | 1.044 | 0.242 | 1.179 |
GSK3B | GSK3B | 0.000 | –1.464 | 0.000 | –1.236 | 0.000 | 1.167 |
CxV | Atp5a1 | 0.000 | –1.407 | 0.011 | 1.143 | 0.023 | 1.123 |
TAU | mapt | 0.000 | –1.358 | 0.544 | –1.051 | 0.899 | 1.01 |
CxI | Ndufv1 | 0.000 | –1.348 | 0.090 | 1.128 | 0.002 | 1.285 |
VDCC | CACNA1C | 0.007 | –1.25 | 0.781 | 1.015 | 0.004 | –1.209 |
CytC | COX4I1 | 0.000 | –1.244 | 0.002 | 1.194 | 0.000 | –1.237 |
Gq | GNAQ | 0.001 | –1.221 | 0.140 | –1.054 | 0.029 | –1.085 |
Fe65 | APBB1 | 0.002 | –1.195 | 0.376 | 1.127 | 0.765 | –1.04 |
BID | BID | 0.04 | –1.192 | 0.008 | 1.116 | 0.561 | –1.021 |
CxII | SDHA | 0.002 | –1.18 | 0.392 | 1.071 | 0.005 | 1.301 |
APP–BP1 | Nae1 | 0.024 | –1.145 | 0.021 | –1.267 | 0.006 | 1.344 |
BAD | Bad | 0.05 | –1.143 | 0.396 | –1.068 | 0.151 | 1.121 |
BACE | BACE1 | 0.224 | –1.113 | 0.005 | –1.302 | 0.003 | 1.326 |
PERK | eif2ak3 | 0.166 | –1.108 | 0.001 | –1.198 | 0.041 | 1.096 |
IRE1A | ERN1 | 0.229 | –1.068 | 0.019 | 1.093 | 0.000 | –1.284 |
CASP9 | Casp9 | 0.245 | –1.058 | 0.495 | 1.081 | 0.228 | –1.15 |
PEN2 | psenen | 0.413 | –1.052 | 0.006 | –1.135 | 0.086 | 1.073 |
NEP | MME | 0.497 | –1.038 | 0.036 | 1.371 | 0.012 | –1.485 |
IDE | IDE | 0.898 | 1.006 | 0.074 | –1.112 | 0.004 | 1.211 |
FADD | Fadd | 0.716 | 1.015 | 0.067 | 1.146 | 0.001 | –1.351 |
NCSTN | NCSTN | 0.266 | 1.042 | 0.704 | 1.031 | 0.318 | 1.085 |
APH–1 | aph1a | 0.239 | 1.058 | 0.360 | 1.052 | 0.36 | 1.052 |
APH–1 | APH1B | 0.204 | 1.063 | 0.032 | –1.121 | 0.336 | –1.048 |
CASP12 | CASP12 | 0.067 | 1.072 | 0.000 | 1.988 | 0.000 | –1.742 |
ABAD | HSD17B10 | 0.181 | 1.081 | 0.000 | 1.351 | 0.049 | –1.07 |
PLC | plcb3 | 0.018 | 1.085 | 0.000 | 1.652 | 0.000 | –1.455 |
CASP3 | Casp3 | 0.032 | 1.091 | 0.010 | –1.234 | 0.02 | 1.204 |
LRP | lrp1 | 0.107 | 1.1 | 0.017 | 1.293 | 0.02 | –1.283 |
APAF1 | Apaf1 | 0.018 | 1.108 | 0.641 | –1.034 | 0.458 | 1.055 |
PSEN | Psen1 | 0.011 | 1.117 | 0.096 | –1.079 | 0.935 | 1.004 |
ATF6 | ATF6B | 0.07 | 1.14 | 0.001 | 1.248 | 0.01 | –1.174 |
CALPAIN | CAPN1 | 0.003 | 1.154 | 0.000 | 1.490 | 0.000 | –1.298 |
ADAM17 | Adam17 | 0.000 | 1.165 | 0.000 | 2.442 | 0.000 | –2.505 |
APOE | APOE | 0.033 | 1.18 | 0.000 | 2.023 | 0.005 | –1.325 |
RYR | RYR3 | 0.001 | 1.184 | 0.000 | 1.480 | 0.000 | –1.707 |
CASP8 | CASP8 | 0.008 | 1.242 | 0.002 | 1.180 | 0.01 | –1.14 |
IP3R | ITPR1 | 0.024 | 1.271 | 0.002 | 1.245 | 0.031 | –1.146 |
CASP7 | casp7 | 0.001 | 1.28 | 0.000 | 1.139 | 0.000 | –1.149 |
CaM | CALM2 | 0.001 | 1.305 | 0.004 | 1.219 | 0.006 | –1.202 |
CaM | calml4 | 0.000 | 1.446 | 0.000 | 1.425 | 0.015 | –1.226 |
LPL | Lpl | 0.02 | 1.481 | 0.000 | 4.445 | 0.000 | –2.672 |
FasTNFR1 | TNFRSF1A | 0.001 | 1.551 | 0.000 | 1.953 | 0.000 | –1.615 |
APP | App | NA | NA | 0.838 | 1.008 | 0.118 | –1.07 |
GAPD | Gapdh | NA | NA | 0.338 | 1.040 | 0.843 | 1.008 |
ERK1 | Mapk3 | NA | NA | 0.040 | 1.084 | 0.006 | –1.124 |