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Table 3 Look-up of Alzheimer’s disease associated genes from KEGG pathways and their expression in hippocampus from Alzheimer’s patients (GSE48350 dataset) and rat CGC glutamate + candesartan treatment

From: An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease

KEGG gene symbol Gene symbol GSE48350 hippocampus ctrl vs AD p value GSE48350 hippocampus ctrl vs AD fold change CGC glutamate vs ctrl p value CGC glutamate vs ctrl fold change CGC glutamate vs glutamate + candesartan p value CGC glutamate vs glutamate + candesartan fold change
NMDAR GRIN1 0.000 –2.184 0.037 –1.191 0.733 1.026
Cn PPP3CB 0.000 –2.111 0.002 –1.245 0.001 1.277
CDK5 cdk5 0.000 –2.039 0.357 –1.041 0.436 1.035
p35 Cdk5r1 0.000 –2.031 0.774 1.040 0.391 –1.126
Cn ppp3ca 0.000 –1.749 0.000 –1.221 0.003 1.158
SERCA ATP2A2 0.000 –1.691 0.002 –1.176 0.001 1.183
PLC PLCB1 0.000 –1.653 0.038 –1.060 0.000 1.147
ERK2 MAPK1 0.000 –1.578 0.012 –1.074 0.026 1.063
CxIII uqcrfs1 0.000 –1.535 0.254 1.099 0.002 1.379
NOS NOS1 0.000 –1.529 0.403 –1.060 0.38 1.063
SNCA Snca 0.000 –1.472 0.755 1.044 0.242 1.179
GSK3B GSK3B 0.000 –1.464 0.000 –1.236 0.000 1.167
CxV Atp5a1 0.000 –1.407 0.011 1.143 0.023 1.123
TAU mapt 0.000 –1.358 0.544 –1.051 0.899 1.01
CxI Ndufv1 0.000 –1.348 0.090 1.128 0.002 1.285
VDCC CACNA1C 0.007 –1.25 0.781 1.015 0.004 –1.209
CytC COX4I1 0.000 –1.244 0.002 1.194 0.000 –1.237
Gq GNAQ 0.001 –1.221 0.140 –1.054 0.029 –1.085
Fe65 APBB1 0.002 –1.195 0.376 1.127 0.765 –1.04
BID BID 0.04 –1.192 0.008 1.116 0.561 –1.021
CxII SDHA 0.002 –1.18 0.392 1.071 0.005 1.301
APP–BP1 Nae1 0.024 –1.145 0.021 –1.267 0.006 1.344
BAD Bad 0.05 –1.143 0.396 –1.068 0.151 1.121
BACE BACE1 0.224 –1.113 0.005 –1.302 0.003 1.326
PERK eif2ak3 0.166 –1.108 0.001 –1.198 0.041 1.096
IRE1A ERN1 0.229 –1.068 0.019 1.093 0.000 –1.284
CASP9 Casp9 0.245 –1.058 0.495 1.081 0.228 –1.15
PEN2 psenen 0.413 –1.052 0.006 –1.135 0.086 1.073
NEP MME 0.497 –1.038 0.036 1.371 0.012 –1.485
IDE IDE 0.898 1.006 0.074 –1.112 0.004 1.211
FADD Fadd 0.716 1.015 0.067 1.146 0.001 –1.351
NCSTN NCSTN 0.266 1.042 0.704 1.031 0.318 1.085
APH–1 aph1a 0.239 1.058 0.360 1.052 0.36 1.052
APH–1 APH1B 0.204 1.063 0.032 –1.121 0.336 –1.048
CASP12 CASP12 0.067 1.072 0.000 1.988 0.000 –1.742
ABAD HSD17B10 0.181 1.081 0.000 1.351 0.049 –1.07
PLC plcb3 0.018 1.085 0.000 1.652 0.000 –1.455
CASP3 Casp3 0.032 1.091 0.010 –1.234 0.02 1.204
LRP lrp1 0.107 1.1 0.017 1.293 0.02 –1.283
APAF1 Apaf1 0.018 1.108 0.641 –1.034 0.458 1.055
PSEN Psen1 0.011 1.117 0.096 –1.079 0.935 1.004
ATF6 ATF6B 0.07 1.14 0.001 1.248 0.01 –1.174
CALPAIN CAPN1 0.003 1.154 0.000 1.490 0.000 –1.298
ADAM17 Adam17 0.000 1.165 0.000 2.442 0.000 –2.505
APOE APOE 0.033 1.18 0.000 2.023 0.005 –1.325
RYR RYR3 0.001 1.184 0.000 1.480 0.000 –1.707
CASP8 CASP8 0.008 1.242 0.002 1.180 0.01 –1.14
IP3R ITPR1 0.024 1.271 0.002 1.245 0.031 –1.146
CASP7 casp7 0.001 1.28 0.000 1.139 0.000 –1.149
CaM CALM2 0.001 1.305 0.004 1.219 0.006 –1.202
CaM calml4 0.000 1.446 0.000 1.425 0.015 –1.226
LPL Lpl 0.02 1.481 0.000 4.445 0.000 –2.672
FasTNFR1 TNFRSF1A 0.001 1.551 0.000 1.953 0.000 –1.615
APP App NA NA 0.838 1.008 0.118 –1.07
GAPD Gapdh NA NA 0.338 1.040 0.843 1.008
ERK1 Mapk3 NA NA 0.040 1.084 0.006 –1.124
  1. AD Alzheimer’s disease, CGC cerebellar granule cell, ctrl control, KEGG Kyoto encyclopedia of genes and genomes, NA not available
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Alzheimer's Research & Therapy

ISSN: 1758-9193