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Table 1 Characteristics for the AD group and the group of healthy elderly individuals

From: Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

  AD HC Group difference
Demographics    
   Number 38 34  
   Age 76 ± 7 77 ± 8 ns
   Gender (F/M) 23/15 24/10 ns
   MMSE 19 ± 5 29 ± 1 P < 10-12
   APOE ε4 heterozygote (homozygote) 63% (13%) 24% (3%) P < 10-4
CSF**    
   Aβ42 307 ± 91 647 ± 166 P < 10-11
   T-tau 938 ± 542 399 ± 194 P < 10-8
   P-tau 106 ± 55* 64 ± 28 P < 10-4
   MMP-1 0.024 ± 0.016 0.021 ± 0.01 ns
   MMP-3 0.716 ± 0.35 0.700 ± 0.36 ns
   MMP-9 0.902 ± 0.39 0.859 ± 0.35 ns
   TIMP-1 0.035 ± 11.7 0.041 ± 13.0 P < 0.05
   MMP-1/TIMP-1 0.697 ± 0.35 0.564 ± 0.25 ns
   MMP-3/TIMP-1 21.1 ± 9.7 18.1 ± 9.8 ns
   MMP-9/TIMP-1 26.9 ± 11.9 22.7 ± 11.8 P < 0.05
  1. Aβ42, β-amyloid1-42; AD, Alzheimer's disease; APOE, apolipoprotein E; CSF, cerebrospinal fluid; F, female; HC, healthy controls; M, male; MMP, matrix metalloproteinase; MMSE, mini mental state examination; TIMP, tissue inhibitor of metalloproteinase.
  2. * n = 28. ** Levels are in ng/l for Aβ42, T-tau and P-tau and in ng/ml for the MMPs and TIMP-1.