AD | HC | Group difference | |
---|---|---|---|
Demographics | |||
Number | 38 | 34 | |
Age | 76 ± 7 | 77 ± 8 | ns |
Gender (F/M) | 23/15 | 24/10 | ns |
MMSE | 19 ± 5 | 29 ± 1 | P < 10-12 |
APOE ε4 heterozygote (homozygote) | 63% (13%) | 24% (3%) | P < 10-4 |
CSF** | |||
Aβ42 | 307 ± 91 | 647 ± 166 | P < 10-11 |
T-tau | 938 ± 542 | 399 ± 194 | P < 10-8 |
P-tau | 106 ± 55* | 64 ± 28 | P < 10-4 |
MMP-1 | 0.024 ± 0.016 | 0.021 ± 0.01 | ns |
MMP-3 | 0.716 ± 0.35 | 0.700 ± 0.36 | ns |
MMP-9 | 0.902 ± 0.39 | 0.859 ± 0.35 | ns |
TIMP-1 | 0.035 ± 11.7 | 0.041 ± 13.0 | P < 0.05 |
MMP-1/TIMP-1 | 0.697 ± 0.35 | 0.564 ± 0.25 | ns |
MMP-3/TIMP-1 | 21.1 ± 9.7 | 18.1 ± 9.8 | ns |
MMP-9/TIMP-1 | 26.9 ± 11.9 | 22.7 ± 11.8 | P < 0.05 |