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Table 1 Characteristics for the AD group and the group of healthy elderly individuals

From: Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

 

AD

HC

Group difference

Demographics

   

   Number

38

34

 

   Age

76 ± 7

77 ± 8

ns

   Gender (F/M)

23/15

24/10

ns

   MMSE

19 ± 5

29 ± 1

P < 10-12

   APOE ε4 heterozygote (homozygote)

63% (13%)

24% (3%)

P < 10-4

CSF**

   

   Aβ42

307 ± 91

647 ± 166

P < 10-11

   T-tau

938 ± 542

399 ± 194

P < 10-8

   P-tau

106 ± 55*

64 ± 28

P < 10-4

   MMP-1

0.024 ± 0.016

0.021 ± 0.01

ns

   MMP-3

0.716 ± 0.35

0.700 ± 0.36

ns

   MMP-9

0.902 ± 0.39

0.859 ± 0.35

ns

   TIMP-1

0.035 ± 11.7

0.041 ± 13.0

P < 0.05

   MMP-1/TIMP-1

0.697 ± 0.35

0.564 ± 0.25

ns

   MMP-3/TIMP-1

21.1 ± 9.7

18.1 ± 9.8

ns

   MMP-9/TIMP-1

26.9 ± 11.9

22.7 ± 11.8

P < 0.05

  1. Aβ42, β-amyloid1-42; AD, Alzheimer's disease; APOE, apolipoprotein E; CSF, cerebrospinal fluid; F, female; HC, healthy controls; M, male; MMP, matrix metalloproteinase; MMSE, mini mental state examination; TIMP, tissue inhibitor of metalloproteinase.
  2. * n = 28. ** Levels are in ng/l for Aβ42, T-tau and P-tau and in ng/ml for the MMPs and TIMP-1.