Miners JS, Baig S, Palmer J, Palmer LE, Kehoe PG, Love S: Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol. 2008, 18: 240-252. 10.1111/j.1750-3639.2008.00132.x.
Article
CAS
PubMed
Google Scholar
Hardy J: Has the amyloid cascade hypothesis for Alzheimer's disease been proved?. Curr Alzheimer Res. 2006, 3: 71-73. 10.2174/156720506775697098.
Article
CAS
PubMed
Google Scholar
Walsh DM, Selkoe DJ: A beta oligomers – a decade of discovery. J Neurochem. 2007, 101: 1172-1184. 10.1111/j.1471-4159.2006.04426.x.
Article
CAS
PubMed
Google Scholar
Congdon EE, Duff KE: Is tau aggregation toxic or protective?. J Alzheimers Dis. 2008, 14: 453-457.
PubMed
Google Scholar
Pakaski M, Kalman J: Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease. Neurochem Int. 2008, 53: 103-111. 10.1016/j.neuint.2008.06.005.
Article
CAS
PubMed
Google Scholar
Miller SA, Accardi JR, St Onge EL: Angiotensin II vaccine: a novel approach in the treatment of hypertension. Expert Opin Biol Ther. 2008, 8: 1669-1673. 10.1517/14712598.8.11.1669.
Article
CAS
PubMed
Google Scholar
von Bohlen und Halbach O, Albrecht D: The CNS renin-angiotensin system. Cell Tissue Res. 2006, 326: 599-616. 10.1007/s00441-006-0190-8.
Article
CAS
PubMed
Google Scholar
Kehoe PG, Wilcock GK: Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?. Lancet Neurol. 2007, 6: 373-378. 10.1016/S1474-4422(07)70077-7.
Article
CAS
PubMed
Google Scholar
Skoog I, Gustafson D: Update on hypertension and Alzheimer's disease. Neurol Res. 2006, 28: 605-611. 10.1179/016164106X130506.
Article
PubMed
Google Scholar
Papademetriou V: Hypertension and cognitive function. Blood pressure regulation and cognitive function: a review of the literature. Geriatrics. 2005, 60: 20-22.
PubMed
Google Scholar
Skoog I, Gustafson D: Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol Res. 2003, 25: 675-680. 10.1179/016164103101201986.
Article
PubMed
Google Scholar
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE: Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007, 39: 17-23. 10.1038/ng1934. Accessed [30th March 2009]
Article
CAS
PubMed
Google Scholar
Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990, 86: 1343-1346. 10.1172/JCI114844.
Article
PubMed Central
CAS
PubMed
Google Scholar
McKenzie CA, Sinsheimer JS, Adeyemo AA, Cox RD, Southam L, Hugill A, Bouzekri N, Lathrop M, Forrester TE, Cooper RS, Ward R: SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models. Ann Hum Genet. 2005, 69: 227-232. 10.1046/j.1469-1809.2004.00142.x.
Article
CAS
PubMed
Google Scholar
Lehmann DJ, Cortina-Borja M, Warden DR, Smith AD, Sleegers K, Prince JA, van Duijn CM, Kehoe PG: Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am J Epidemiol. 2005, 162: 305-317. 10.1093/aje/kwi202.
Article
PubMed
Google Scholar
Kauwe J, Wang J, Mayo K, Morris J, Fagan A, Holtzman D, Goate A: Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics. 2009, 10: 13-17. 10.1007/s10048-008-0150-4.
Article
PubMed Central
CAS
PubMed
Google Scholar
Meng Y, Baldwin CT, Bowirrat A, Waraska K, Inzelberg R, Friedland RP, Farrer LA: Association of polymorphisms in the angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community. Am J Hum Genet. 2006, 78: 871-877. 10.1086/503687.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schjeide BM, McQueen MB, Mullin K, Divito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L: Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 2009, 10: 19-25. 10.1007/s10048-008-0151-3.
Article
PubMed Central
PubMed
Google Scholar
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD: An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. Am J Med Genet B Neuropsychiatr Genet. 2008,
Google Scholar
Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung GY, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I, Matthews PM: Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol. 2008, 65: 45-53. 10.1001/archneurol.2007.3.
Article
PubMed
Google Scholar
Miners JS, Ashby E, Harrison R, Speedy E, Baig S, Prince JA, Love S, Kehoe PG: Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes. Am J Translational Res. 2009, 1: 163-177.
CAS
Google Scholar
Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S, Kehoe PG: Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol. 2008, 34: 181-193. 10.1111/j.1365-2990.2007.00885.x.
Article
CAS
PubMed
Google Scholar
Savaskan E: The role of the brain renin-angiotensin system in neurodegenerative disorders. Curr Alzheimer Res. 2005, 2: 29-35. 10.2174/1567205052772740.
Article
CAS
PubMed
Google Scholar
Kehoe PG: The renin-angiotensin-aldosterone system and Alzheimer s disease?. J Renin Angiotensin Aldosterone Syst. 2003, 4: 80-93. 10.3317/jraas.2003.017.
Article
CAS
PubMed
Google Scholar
Zubenko GS, Volicer L, Direnfeld LK, Freeman M, Langlais PJ, Nixon RA: Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Brain Res. 1985, 328: 215-221. 10.1016/0006-8993(85)91032-7.
Article
CAS
PubMed
Google Scholar
Zubenko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon RA: Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study. Biol Psychiatry. 1986, 21: 1365-1381. 10.1016/0006-3223(86)90328-8.
Article
CAS
PubMed
Google Scholar
Konings CH, Kuiper MA, Scheltens P, Grijpma AM, van Pelt W, Wolters EC: Re-evaluation of cerebrospinal fluid angiotensin-converting enzyme activity in patients with 'probable' Alzheimer's disease. Eur J Clin Chem Clin Biochem. 1993, 31: 495-497.
CAS
PubMed
Google Scholar
Nielsen HM, Londos E, Minthon L, Janciauskiene SM: Soluble adhesion molecules and angiotensin-converting enzyme in dementia. Neurobiol Dis. 2007, 26: 27-35. 10.1016/j.nbd.2006.11.011.
Article
CAS
PubMed
Google Scholar
Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DM: The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease. Neurosci Lett. 2002, 328: 314-318. 10.1016/S0304-3940(02)00553-0.
Article
CAS
PubMed
Google Scholar
Danilov S, Savoie F, Lenoir B, Jeunemaitre X, Azizi M, Tarnow L, Alhenc-Gelas F: Development of enzyme-linked immunoassays for human angiotensin I converting enzyme suitable for large-scale studies. J Hypertens. 1996, 14: 719-727. 10.1097/00004872-199606000-00007.
Article
CAS
PubMed
Google Scholar
Vardy ER, Rice PJ, Bowie PC, Holmes JD, Catto AJ, Hooper NM: Plasma Angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis. 2009, 16: 609-618.
CAS
PubMed
Google Scholar
Toropygin IY, Kugaevskaya EV, Mirgorodskaya OA, Elisseeva YE, Kozmin YP, Popov IA, Nikolaev EN, Makarov AA, Kozin SA: The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1–16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2008, 22: 231-239. 10.1002/rcm.3357.
Article
CAS
PubMed
Google Scholar
Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K, Michikawa M: Angiotensin-converting enzyme converts amyloid beta-protein 1–42 (Abeta(1–42)) to Abeta(1–40), and its inhibition enhances brain Abeta deposition. J Neurosci. 2007, 27: 8628-8635. 10.1523/JNEUROSCI.1549-07.2007.
Article
CAS
PubMed
Google Scholar
Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM: Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007, 117: 3393-3402. 10.1172/JCI31547.
Article
PubMed Central
CAS
PubMed
Google Scholar
Takeda S, Sato N, Rakugi H, Morishita R: Improvement of cognitive decline and cerebrovascular dysfunction in a mouse model of Alzheimer's disease by angiotensin receptor blocker, Olmesartan. Alzheimer's Dementia. 2008, 4: T479-10.1016/j.jalz.2008.05.1442.
Article
Google Scholar
Sun X, Becker M, Pankow K, Krause E, Ringling M, Beyermann M, Maul B, Walther T, Siems W-E: Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-[beta] peptides. Eur J Pharmacol. 2008, 588: 18-25. 10.1016/j.ejphar.2008.03.058.
Article
CAS
PubMed
Google Scholar
Gard PR: Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression. Expert Opin Ther Targets. 2004, 8: 7-14. 10.1517/14728222.8.1.7.
Article
CAS
PubMed
Google Scholar
Barnes JM, Barnes NM, Costall B, Coughlan J, Kelly ME, Naylor RJ, Tomkins DM, Williams TJ: Angiotensin-converting enzyme inhibition, angiotensin, and cognition. J Cardiovasc Pharmacol. 1992, 19 (Suppl 6): S63-71.
Article
CAS
PubMed
Google Scholar
Hamdi HK, Castellon R: A genetic variant of ACE increases cell survival: a new paradigm for biology and disease. Biochem Biophys Res Commun. 2004, 318: 187-191. 10.1016/j.bbrc.2004.04.004.
Article
CAS
PubMed
Google Scholar
Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL: Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. BMC Neurosci. 2008, 9 (Suppl 2): S14-10.1186/1471-2202-9-S2-S14.
Article
PubMed Central
PubMed
Google Scholar
Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, Waldman A, Walton I, Poulter R, Ma S, Comsa M, Burch L, Fletcher A, Bulpitt C, HYVET investigators: Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol. 2008, 7: 683-689. 10.1016/S1474-4422(08)70143-1.
Article
CAS
PubMed
Google Scholar
Rosenberg PB, Mielke MM, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG: Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry. 2008, 16: 883-892. 10.1097/JGP.0b013e318181276a.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fogari R, Mugellini A, Zoppi A, Derosa G, Pasotti C, Fogari E, Preti P: Influence of losartan and atenolol on memory function in very elderly hypertensive patients. J Hum Hypertens. 2003, 17: 781-785. 10.1038/sj.jhh.1001613.
Article
CAS
PubMed
Google Scholar
Tedesco MA, Ratti G, Di Salvo G, Natale F: Does the angiotensin II receptor antagonist losartan improve cognitive function?. Drugs Aging. 2002, 19: 723-732. 10.2165/00002512-200219100-00001.
Article
CAS
PubMed
Google Scholar
Hajjar I, Catoe H, Sixta S, Boland R, Johnson D, Hirth V, Wieland D, Eleazer P: Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population. J Gerontol A Biol Sci Med Sci. 2005, 60: 67-73.
Article
PubMed
Google Scholar
Wolozin B, Lee A, Lee A, Whitmer R, Kaziz L: Use of angiotensin receptor blockers is associated with lower incidence and progression of Alzheimer's disease. Alzheimer's Dementia. 2008, 4: T118-10.1016/j.jalz.2008.05.251.
Article
Google Scholar
Cushman DW, Wang Fl, Fung WC, Harvey CM, DeForrest JM: Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs. Am J Hypertens. 1989, 2: 294-306.
CAS
PubMed
Google Scholar
Weiner MF, Bonte FJ, Tintner R, Ford N, Svetlik D, Riall T: ACE inhibitor lacks acute effect on cognition or brain blood flow in Alzheimer's disease. Drug Dev Res. 1992, 26: 467-471. 10.1002/ddr.430260410.
Article
CAS
Google Scholar
Sudilovsky A, Cutler NR, Sramek JJ, Wardle T, Veroff AE, Mickelson W, Markowitz J, Repetti S: A pilot clinical trial of the angiotensin-converting enzyme inhibitor ceranapril in Alzheimer disease. Alzheimer Dis Assoc Disord. 1993, 7: 105-111. 10.1097/00002093-199307020-00006.
Article
CAS
PubMed
Google Scholar
Louis WJ, Mander AG, Dawson M, O'Callaghan C, Conway EL: Use of computerized neuropsychological tests (CANTAB) to assess cognitive effects of antihypertensive drugs in the elderly. Cambridge Neuropsychological Test Automated Battery. J Hypertens. 1999, 17: 1813-1819. 10.1097/00004872-199917121-00005.
Article
CAS
PubMed
Google Scholar
Haulica I, Bild W, Serban DN: Angiotensin peptides and their pleiotropic actions. J Renin Angiotensin Aldosterone Syst. 2005, 6: 121-131. 10.3317/jraas.2005.018.
Article
CAS
PubMed
Google Scholar