Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR: Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med. 2013, 5: 206ra138-
Article
PubMed
Google Scholar
Axten JM, Medina JR, Feng Y, Shu A, Romeril SP, Grant SW, Li WH, Heerding DA, Minthorn E, Mencken T, Atkins C, Liu Q, Rabindran S, Kumar R, Hong X, Goetz A, Stanley T, Taylor JD, Sigethy SD, Tomberlin GH, Hassell AM, Kahler KM, Shewchuk LM, Gampe RT: Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012, 55: 7193-7207. 10.1021/jm300713s.
Article
CAS
PubMed
Google Scholar
Wek RC, Cavener DR: Translational control and the unfolded protein response. Antioxid Redox Signal. 2007, 9: 2357-2371. 10.1089/ars.2007.1764.
Article
CAS
PubMed
Google Scholar
Trinh MA, Klann E: Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory. Neurobiol Learn Mem. 2013, 105: 93-99.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wek RC, Jiang H-Y, Anthony TG: Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006, 34: 7-11. 10.1042/BST0340007.
Article
CAS
PubMed
Google Scholar
Paschen W, Proud CG, Mies G: Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. Curr Pharm Des. 2007, 13: 1887-1902. 10.2174/138161207780858401.
Article
CAS
PubMed
Google Scholar
Klann E, Richter JD: Translational control of synaptic plasticity and learning and memory. Translational Control in Biology and Medicine. Edited by: Mathews MB, Sonenberg N, Hershey JW. 2007, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 485-506.
Google Scholar
Alberini C: The role of protein synthesis during the labile phases of memory: revisiting the skepticism. Neurobiol Learn Mem. 2008, 89: 234-246. 10.1016/j.nlm.2007.08.007.
Article
PubMed Central
CAS
PubMed
Google Scholar
Roussel BD, Kruppa AJ, Miranda E, Crowther DC, Lomas DA, Marciniak SJ: Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol. 2013, 12: 105-118. 10.1016/S1474-4422(12)70238-7.
Article
CAS
PubMed
Google Scholar
Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E: Suppression of eIF2α kinases alleviates Alzheimer’s disease-related plasticity and memory deficits. Nat Neurosci. 2013, 16: 1299-1305. 10.1038/nn.3486.
Article
PubMed Central
CAS
PubMed
Google Scholar
Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E: Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep. 2012, 1: 676-688. 10.1016/j.celrep.2012.04.010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR: The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002, 22: 3864-3874. 10.1128/MCB.22.11.3864-3874.2002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Senée V, Vattem KM, Delépine M, Rainbow LA, Haton C, Lecoq A, Shaw NJ, Robert JJ, Rooman R, Diatloff-Zito C, Michaud JL, Bin-Abbas B, Taha D, Zabel B, Franceschini P, Topaloglu AK, Lathrop GM, Barrett TG, Nicolino M, Wek RC, Julier C: Wolcott-Rallison syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes. 2004, 53: 1876-1883. 10.2337/diabetes.53.7.1876.
Article
PubMed
Google Scholar
Galasko D, Golde TE: Biomarkers for Alzheimer’s disease in plasma, serum and blood - conceptual and practical problems. Alzheimers Res Ther. 2013, 5: 10-10.1186/alzrt164.
Article
PubMed Central
PubMed
Google Scholar
Golde TE: Open questions for Alzheimer’s disease immunotherapy. Alzheimers Res Ther. 2014, 6: 3-10.1186/alzrt233.
Article
PubMed Central
PubMed
Google Scholar