Prins ND, Scheltens P: Treating Alzheimer’s disease with monoclonal antibodies; current status and outlook to the future. Alzheimers Res Ther. 2013, 5: 56-10.1186/alzrt220.
Article
PubMed Central
PubMed
Google Scholar
Golde TE, Das P, Levites Y: Quantitative and mechanistic studies of abeta immunotherapy. CNS Neurol Disord Drug Targets. 2009, 8: 31-49. 10.2174/187152709787601830.
Article
CAS
PubMed
Google Scholar
Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE: Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer’s disease mouse models. FASEB J. 2006, 20: 2576-2578. 10.1096/fj.06-6463fje.
Article
CAS
PubMed
Google Scholar
Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, Scearce-Levie K, Wang W, Wu Y, Tessier-Lavigne M, Watts RJ: A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci Transl Med. 2011, 3: 84ra43-10.1126/scitranslmed.3002254.
Article
PubMed
Google Scholar
Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS: Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med. 2011, 3: 84ra44-10.1126/scitranslmed.3002230.
Article
PubMed
Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM: Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease. Science. 2002, 295: 2264-2267. 10.1126/science.1067568.
Article
CAS
PubMed
Google Scholar
Bickel U, Yoshikawa T, Pardridge WM: Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev. 2001, 46: 247-279. 10.1016/S0169-409X(00)00139-3.
Article
CAS
PubMed
Google Scholar
Lee HJ, Engelhardt B, Lesley J, Bickel U, Pardridge WM: Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J Pharmacol Exp Ther. 2000, 292: 1048-1052.
CAS
PubMed
Google Scholar
Thakker DR, Weatherspoon MR, Harrison J, Keene TE, Lane DS, Kaemmerer WF, Stewart GR, Shafer LL: Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009, 106: 4501-4506. 10.1073/pnas.0813404106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Paganetti P, Reichwald J, Bleckmann D, Abramowski D, Ammaturo D, Barske C, Danner S, Molinari M, Müller M, Papin S, Rabe S, Schmid P, Staufenbiel M: Transgenic expression of beta1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice. Neurobiol Aging. 2013, 34: 2866-2878. 10.1016/j.neurobiolaging.2013.06.013.
Article
CAS
PubMed
Google Scholar
Irani SR, Vincent A: NMDA receptor antibody encephalitis. Curr Neurol Neurosci Rep. 2011, 11: 298-304. 10.1007/s11910-011-0186-y.
Article
CAS
PubMed
Google Scholar
Panzer J, Dalmau J: Movement disorders in paraneoplastic and autoimmune disease. Curr Opin Neurol. 2011, 24: 346-353. 10.1097/WCO.0b013e328347b307.
Article
PubMed Central
PubMed
Google Scholar
Strazielle N, Ghersi-Egea JF: Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Mol Pharm. 2013, 10: 1473-1491. 10.1021/mp300518e.
Article
CAS
PubMed
Google Scholar
Zhang Y, Pardridge WM: Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier. J Neuroimmunol. 2001, 114: 168-172. 10.1016/S0165-5728(01)00242-9.
Article
CAS
PubMed
Google Scholar
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV: IgG-assisted age-dependent clearance of Alzheimer’s amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005, 25: 11495-11503. 10.1523/JNEUROSCI.3697-05.2005.
Article
CAS
PubMed
Google Scholar
Abuqayyas L, Balthasar JP: Investigation of the role of FcgammaR and FcRn in mAb distribution to the brain. Mol Pharm. 2013, 10: 1505-1513. 10.1021/mp300214k.
Article
CAS
PubMed
Google Scholar
Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H: Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 2013, 123: 1299-1309. 10.1172/JCI67677.
Article
PubMed Central
CAS
PubMed
Google Scholar
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M: A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012, 4: 147ra111-10.1126/scitranslmed.3003748.
Article
PubMed Central
PubMed
Google Scholar
Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M: Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med. 2013, 11: 107-10.1186/1479-5876-11-107.
Article
PubMed Central
PubMed
Google Scholar
Weller RO, Preston SD, Subash M, Carare RO: Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease. Alzheimers Res Ther. 2009, 1: 6-10.1186/alzrt6.
Article
PubMed Central
PubMed
Google Scholar
Yu YJ, Watts RJ: Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics. 2013, 10: 459-472. 10.1007/s13311-013-0187-4.
Article
PubMed Central
PubMed
Google Scholar
Seubert P, Barbour R, Khan K, Motter R, Tang P, Kholodenko D, Kling K, Schenk D, Johnson-Wood K, Schroeter S, Gill D, Jacobsen JS, Pangalos M, Basi G, Games D: Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse. Neurodegener Dis. 2008, 5: 65-71. 10.1159/000112834.
Article
CAS
PubMed
Google Scholar
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM: Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer’s disease model. Nat Neurosci. 2002, 5: 452-457.
CAS
PubMed
Google Scholar
Jawhar S, Wirths O, Bayer TA: Pyroglutamate amyloid-beta (Abeta): a hatchet man in Alzheimer disease. J Biol Chem. 2011, 286: 38825-38832. 10.1074/jbc.R111.288308.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT: Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron. 2011, 71: 833-844. 10.1016/j.neuron.2011.07.001.
Article
CAS
PubMed
Google Scholar
Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA: Pyroglutamate-3 amyloid-beta deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013, 183: 369-381. 10.1016/j.ajpath.2013.05.005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Demattos RB, Lu J, Tang Y, Racke MM, Delong CA, Tzaferis JA, Hole JT, Forster BM, McDonnell PC, Liu F, Kinley RD, Jordan WH, Hutton ML: A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer’s disease mice. Neuron. 2012, 76: 908-920. 10.1016/j.neuron.2012.10.029.
Article
CAS
PubMed
Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM: Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2001, 98: 8850-8855. 10.1073/pnas.151261398.
Article
PubMed Central
CAS
PubMed
Google Scholar
Levites Y, Jansen K, Smithson LA, Dakin R, Holloway VM, Das P, Golde TE: Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci. 2006, 26: 11923-11928. 10.1523/JNEUROSCI.2795-06.2006.
Article
CAS
PubMed
Google Scholar
Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE: Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J Neurosci. 2003, 23: 8532-8538.
CAS
PubMed
Google Scholar
Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT: Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002, 22: 7873-7878.
CAS
PubMed
Google Scholar
Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ: An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta. J Neurosci. 2012, 32: 9677-9689. 10.1523/JNEUROSCI.4742-11.2012.
Article
CAS
PubMed
Google Scholar
Ostrowitzki S, Deptula D, Thurfjell L, Barkhof F, Bohrmann B, Brooks DJ, Klunk WE, Ashford E, Yoo K, Xu ZX, Loetscher H, Santarelli L: Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch Neurol. 2012, 69: 198-207. 10.1001/archneurol.2011.1538.
Article
PubMed
Google Scholar
Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H: Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta. J Alzheimers Dis. 2012, 28: 49-69.
CAS
PubMed
Google Scholar
Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D: Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci. 2006, 26: 5340-5346. 10.1523/JNEUROSCI.0695-06.2006.
Article
CAS
PubMed
Google Scholar
Sperling RA, Jack CR, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ: Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer’s Association Research Roundtable Workgroup. Alzheimers Dement. 2011, 7: 367-385. 10.1016/j.jalz.2011.05.2351.
Article
PubMed Central
PubMed
Google Scholar
Sperling R, Salloway S, Brooks DJ, Tampieri D, Barakos J, Fox NC, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Lieberburg I, Arrighi HM, Morris KA, Lu Y, Liu E, Gregg KM, Brashear HR, Kinney GG, Black R, Grundman M: Amyloid-related imaging abnormalities in patients with Alzheimer’s disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol. 2012, 11: 241-249. 10.1016/S1474-4422(12)70015-7.
Article
PubMed Central
CAS
PubMed
Google Scholar
Winblad B, Andreasen N, Minthon L, Floesser A, Imbert G, Dumortier T, Maguire RP, Blennow K, Lundmark J, Staufenbiel M, Orgogozo JM, Graf A: Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurol. 2012, 11: 597-604. 10.1016/S1474-4422(12)70140-0.
Article
CAS
PubMed
Google Scholar
Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo JM, AN1792(QS-21)-201 Study Team: Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005, 64: 1553-1562. 10.1212/01.WNL.0000159740.16984.3C.
Article
CAS
PubMed
Google Scholar
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C: Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology. 2003, 61: 46-54. 10.1212/01.WNL.0000073623.84147.A8.
Article
CAS
PubMed
Google Scholar
Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA: Long-term effects of Abeta42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 2008, 372: 216-223. 10.1016/S0140-6736(08)61075-2.
Article
CAS
PubMed
Google Scholar
Boche D, Donald J, Love S, Harris S, Neal JW, Holmes C, Nicoll JA: Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer’s disease. Acta Neuropathol. 2010, 120: 13-20. 10.1007/s00401-010-0705-y.
Article
CAS
PubMed
Google Scholar
Sigurdsson EM: Immunotherapy targeting pathological tau protein in Alzheimer’s disease and related tauopathies. J Alzheimers Dis. 2008, 15: 157-168.
PubMed Central
CAS
PubMed
Google Scholar
Gu J, Sigurdsson EM: Immunotherapy for tauopathies. J Mol Neurosci. 2011, 45: 690-695. 10.1007/s12031-011-9576-5.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM: In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011, 31: 13110-13117. 10.1523/JNEUROSCI.2569-11.2011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K: Trans-synaptic spread of tau pathology in vivo. PLoS One. 2012, 7: e31302-10.1371/journal.pone.0031302.
Article
PubMed Central
CAS
PubMed
Google Scholar
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT: Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 2012, 73: 685-697. 10.1016/j.neuron.2011.11.033.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM: Anti-Tau antibodies that block Tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. 2013, 80: 402-414. 10.1016/j.neuron.2013.07.046.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fernandez-Vizarra P, Lopez-Franco O, Mallavia B, Higuera-Matas A, Lopez-Parra V, Ortiz-Munoz G, Ambrosio E, Egido J, Almeida OF, Gomez-Guerrero C: Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice. Brain. 2012, 135: 2826-2837. 10.1093/brain/aws195.
Article
PubMed
Google Scholar
Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J: Autoreactive-Abeta antibodies promote APP beta-secretase processing. J Neurochem. 2012, 120: 732-740. 10.1111/j.1471-4159.2011.07629.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gu J, Congdon EE, Sigurdsson EM: Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau pathology. J Biol Chem. 2013, [epub ahead of print]
Google Scholar
McEwan WA, Mallery DL, Rhodes DA, Trowsdale J, James LC: Intracellular antibody-mediated immunity and the role of TRIM21. Bioessays. 2011, 33: 803-809. 10.1002/bies.201100093.
Article
CAS
PubMed
Google Scholar
Golde TE, Schneider LS, Koo EH: Anti-abeta therapeutics in Alzheimer’s disease: the need for a paradigm shift. Neuron. 2011, 69: 203-213. 10.1016/j.neuron.2011.01.002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA, Blennow K, Barakos J, Okello AA, Rodriguez Martinez de Liano S, Liu E, Koller M, Gregg KM, Schenk D, Black R, Grundman M: 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol. 2010, 9: 363-372. 10.1016/S1474-4422(10)70043-0.
Article
CAS
PubMed
Google Scholar
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P: Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999, 400: 173-177. 10.1038/22124.
Article
CAS
PubMed
Google Scholar
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T: Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000, 6: 916-919. 10.1038/78682.
Article
CAS
PubMed
Google Scholar