Hebert LE, Weuve J, Scherr PA, Evans DA: Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 2013, 80: 1778-1783. 10.1212/WNL.0b013e31828726f5.
Article
PubMed Central
PubMed
Google Scholar
Tejada-Vera B: Mortality From Alzheimer’s Disease in the United States: Data for 2000 and 2010. NCHS data brief, no. 116. 2013, National Center for Health Statistics: Hyattsville, MD
Google Scholar
Holtzman DM, Morris JC, Goate AM: Alzheimer’s disease: the challenge of the second century. Sci Transl Med. 2011, 77: 77sr1-
Google Scholar
Sperling RA, Jack CR, Aisen PS: Testing the right target and right drug at the right stage. Sci Transl Med. 2011, 3: 111cm33-10.1126/scitranslmed.3002609.
Article
PubMed Central
PubMed
Google Scholar
Price JL, McKeel DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC: Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009, 30: 1026-1036. 10.1016/j.neurobiolaging.2009.04.002.
Article
PubMed Central
PubMed
Google Scholar
Price JL, Morris JC: Tangles and plaques in nondemented aging and ‘preclinical’ Alzheimer’s disease. Annals Neurol. 1999, 45: 358-368. 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X.
Article
CAS
Google Scholar
Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC: Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol. 2003, 62: 1087-1095.
CAS
PubMed
Google Scholar
Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS: Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006, 66: 1837-1844. 10.1212/01.wnl.0000219668.47116.e6.
Article
CAS
PubMed
Google Scholar
Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC: Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol. 2001, 58: 1395-1402. 10.1001/archneur.58.9.1395.
Article
CAS
PubMed
Google Scholar
Gomez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J Neurosci. 1996, 16: 4491-4500.
CAS
PubMed
Google Scholar
Monsell SE, Mock C, Roe CM, Ghoshal N, Morris JC, Cairns NJ, Kukull W: Comparison of symptomatic and asymptomatic persons with Alzheimer disease neuropathology. Neurology. 2013, 80: 2121-2129. 10.1212/WNL.0b013e318295d7a1.
Article
PubMed Central
PubMed
Google Scholar
Fagan AM, Roe CM, Xiong C, Morris JC, Holtzman DM: Cerebrospinal fluid tau/β-amyloid 42 ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol. 2007, 64: 343-349. 10.1001/archneur.64.3.noc60123.
Article
PubMed
Google Scholar
Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA: Pittsburgh Compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer’s disease. Arch Neurol. 2009, 66: 1469-1475. 10.1001/archneurol.2009.269.
Article
PubMed Central
PubMed
Google Scholar
Villemagne VL, Pike KE, Chetelat G, Ellis KA, Mulligan RS, Bourgeat P, Ackermann U, Jones G, Szoeke C, Salvado O, Martins R, O’Keefe G, Mathis CA, Klunk WE, Ames D, Masters CL, Rowe CC: Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Annals Neurol. 2011, 69: 181-192. 10.1002/ana.22248.
Article
CAS
Google Scholar
Jack CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ: Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013, 12: 207-216. 10.1016/S1474-4422(12)70291-0.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nussbaum RL, Ellis CE: Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003, 348: 1356-1364. 10.1056/NEJM2003ra020003.
Article
CAS
PubMed
Google Scholar
Snider BJ, Norton J, Coats MA, Chakraverty S, Hou CE, Jervis R, Lendon CL, Goate AM, McKeel DW, Morris JC: Novel Presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. Arch Neurol. 2005, 62: 1821-1830. 10.1001/archneur.62.12.1821.
Article
PubMed
Google Scholar
Bateman RJ, Aisen PS, Strooper BD, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C: Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011, 3: 1-
Article
PubMed Central
PubMed
Google Scholar
Lippa CF, Swearer JM, Kane KJ, Nochlin D, Bird TD, Ghetti B, Nee LE, St George-Hyslop P, Pollen DA, Drachman DA: Familial Alzheimer’s disease: site of mutation influences clinical phenotype. Annals Neurol. 2000, 48: 376-379. 10.1002/1531-8249(200009)48:3<376::AID-ANA13>3.0.CO;2-U.
Article
CAS
Google Scholar
Mullan M, Houlden H, Crawford F, Kennedy A, Rogues P, Rossor M: Age of onset in familial early onset Alzheimer’s disease correlates with genetic aetiology. Am J Med Genet Neuropsychiat Genet. 1993, 48: 129-130. 10.1002/ajmg.1320480303.
Article
CAS
Google Scholar
Cruts M, Theuns J, Van Broeckhoven C: Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat. 2012, 33: 1340-1344. 10.1002/humu.22117.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fox NC, Warrington EK, Seiffer AL, Agnew SK, Rossor MN: Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer’s disease: a longitudinal prospective study. Brain. 1998, 121: 1631-1639. 10.1093/brain/121.9.1631.
Article
PubMed
Google Scholar
Mosconi L, Sorbi S, de Leon MJ, Nacmias B, Myoung PS, Tsui W, Ginestroni A, Bessi V, Fayyazz M, Caffarra P, Pupi A: Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer’s disease. J Nucl Med. 2006, 47: 1778-1786.
CAS
PubMed
Google Scholar
Ringman JM: What the study of persons at risk for familial Alzheimer’s disease can tell us about the earliest stages of the disorder: a review. J Geriatr Psychiatry Neurol. 2005, 18: 228-233. 10.1177/0891988705281878.
Article
PubMed
Google Scholar
Knight WD, Kim LG, Douiri A, Frost C, Rossor MN, Fox NC: Acceleration of cortical thinning in familial Alzheimer’s disease. Neurobiol Aging. 2011, 32: 1765-1773. 10.1016/j.neurobiolaging.2009.11.013.
Article
CAS
PubMed
Google Scholar
Wallon D, Rousseau S, Rovelet-Lecrux A, Quillard-Muraine M, Guyant-Maréchal L, Martinaud O, Pariente J, Puel M, Rollin-Sillaire A, Pasquier F, Le Ber I, Sarazin M, Croisile B, Boutoleau-Bretonnière C, Thomas-Antérion C, Paquet C, Moreaud O, Gabelle A, Sellal F, Sauvée M, Laquerrière A, Duyckaerts C, Delisle MB, Streichenberger N, Lannes B, Frebourg T, Hannequin D, Campion D: The French series of autosomal dominant early onset Alzheimer’s disease cases: mutation spectrum and cerebrospinal fluid biomarkers. J Alzheimers Dis. 2012, 30: 847-856.
CAS
PubMed
Google Scholar
Lopera F, Ardilla A, Martinez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, Rosselli M, Kosik KS: Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA. 1997, 277: 793-799. 10.1001/jama.1997.03540340027028.
Article
CAS
PubMed
Google Scholar
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gomez MG, Langois CM, Langbaum JB, Ayutyanont N, Roontiva A, Thiyyagura P, Lee W, Mo H, Lopez L, Moreno S, Acosta-Baena N, Giraldo M, Garcia G, Reiman RA, Huentelman MJ, Kosik KS, Tariot PN, Lopera F, Reiman EM: Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional study. Lancet Neurol. 2012, 11: 1057-1065. 10.1016/S1474-4422(12)70227-2.
Article
CAS
PubMed
Google Scholar
Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JB, Kosik KS, Tariot PN, Lopera F: Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case–control study. Lancet Neurol. 2012, 11: 1048-1056. 10.1016/S1474-4422(12)70228-4.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dominantly Inherited Alzheimer Network home page.http://dian-info.org/,
Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD: Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Invest. 2012, 2: 975-984. 10.4155/cli.12.93.
Article
CAS
Google Scholar
Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC: Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012, 367: 795-804. 10.1056/NEJMoa1202753.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH: Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alz Dement. 2011, 7: 280-292. 10.1016/j.jalz.2011.03.003.
Article
Google Scholar
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alz Dement. 2011, 7: 270-279. 10.1016/j.jalz.2011.03.008.
Article
Google Scholar
McKhann GM, Knopman DS, Chertkow H, Hynes M, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alz Dement. 2011, 7: 263-269. 10.1016/j.jalz.2011.03.005.
Article
Google Scholar
Snider BJ, Buckles VD: ‘Will I get Alzheimer disease?’ when cognitively normal patients ask to be tested for Alzheimer disease. Continuum. 2013, 19: 470-474.
PubMed
Google Scholar
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S: Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat Med. 1996, 2: 864-870. 10.1038/nm0896-864.
Article
CAS
PubMed
Google Scholar
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D’Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B: Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO. 2010, 29: 3408-3420. 10.1038/emboj.2010.211.
Article
CAS
Google Scholar
Bateman RJ, Klunk WE: Measuring target effect of proposed disease-modifying therapies in Alzheimer’s disease. Neurotherapeutics. 2008, 5: 381-390. 10.1016/j.nurt.2008.05.009.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dominantly Inherited Alzheimer’s Network (DIAN) Expanded Registry Pharma Consortium Members.http://dianxr.org/pharma.htm,
Dominantly Inherited Alzheimer’s Network (DIAN) Expanded Registry.http://www.dianxr.org/,
Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA: Can we prevent Alzheimer’s disease? Secondary ‘prevention’ trials in Alzheimer’s disease. Alz Dement. 2013, 9: 123-131. 10.1016/j.jalz.2012.12.004.
Article
Google Scholar
Reiman EM, Langbaum JB, Fleisher AS, Caselli RJ, Chen K, Ayutyanont N, Quiroz YT, Kosik KS, Lopera F, Tariot PN: Alzheimer’s Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alz Dis. 2011, 26S3: 321-329.
Google Scholar