Fig. 1

GVD and NFT at the CA2–CA1 boundary. a CA2–CA1 boundary at 159× magnification; scale bar = 100 μm. b Marked area in A at 638× magnification; scale bar = 20 μm: 1 NFT bearing neuron, 2, 3 neurons with both GVD granules and fibrils that under low power in A could be mistaken for ‘pure’ NFT, 4 two neurons with diffuse tau staining lacking any clear morphology and showing a clear hard line around the nucleus, 5 a neuron with GVD also containing two larger discrete fibrous bundles, *examples of neurons with GVD. c The cell marked 3 at 1600× magnification showing GVD and fibrils; scale bar = 20 μm. CA cornus ammonis, GVD granulovacuolar degeneration, NFT neurofibrillary tangles