Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men

Table 2 Plasma NfL’s associations with cognition in the full sample

Model: Cognitive Domain ∼ Age + Health Status + Young Adult GCA + Plasma NfL
Outcomes	Beta Estimate	95% CI [upper, lower]	Uncorrected P value	FDR-corrected P value
Executive Function	-0.05	[-0.11, 0.01]	0.073	0.073
Episodic Memory	-0.06	[-0.12, 0.01]	0.094	0.075
Verbal Fluency	-0.06	[-0.12, 0.00]	0.066	0.073
Processing Speed	-0.12	[-0.18, -0.05]	< 0.0001	0.0004
Visual-spatial Ability	-0.05	[-0.10, 0.00]	0.051	0.073

Note: N = 956, except visual-spatial ability (N = 955). Plasma NfL’s beta estimates, 95% CI, and p values are shown. Significant associations with cognitive domains are shown in bold

ISSN: 1758-9193