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Table 3 The BMI-stratified individual and combined effects of the associations of BW cycle and BW variability (VIM) with incident dementia (Data are hazard ratios with 95% CI.)

From: Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study

 

BMI < 25 kg/m2

(N = 2,356,669)

BMI ≥ 25 kg/m2

(N = 1,279,319)

 

BW cycle only

VIM Q1

VIM Q2

VIM Q3

VIM Q4

BW cycle only

VIM Q2

VIM Q1

VIM Q2

VIM Q3

VIM only

–

1.0

(ref)

1.09

(1.03–1.15)

1.26

(1.20–1.32)

1.57

(1.50–1.65)

–

1.0

(ref)

1.07

(1.00–1.14)

1.20

(1.12–1.28)

1.45

(1.36–1.54)

< 3%

(N = 1,166,108)

1.0

(ref)

1.0

(ref)

1.12

(1.03–1.22)

1.17

(1.07–1.27)

1.52

(1.40–1.65)

1.0

(ref)

1.0

(ref)

1.08

(0.97–1.20)

1.11

(0.99–1.24)

1.38

(1.23–1.54)

3%

1 time

(N = 1,250,801)

1.07

(1.03–1.12)

1.06

(0.97–1.15)

1.02

(0.93–1.12)

1.31

(1.19–1.45)

1.41

(1.26–1.57)

1.07

(1.02–1.13)

0.99

(0.89–1.10)

1.04

(0.92–1.16)

1.07

(0.93–1.23)

1.07

(1.02–1.13)

≥ 2 times

(N = 1,219,079)

1.12

(1.07–1.17)

0.92

(0.81–1.04)

1.10

(0.99–1.222

1.35

(1.21–1.51)

1.40

(1.24–1.59)

1.14

(1.08–1.21)

0.94

(0.79–1.12)

1.19

(1.03–1.37)

1.13

(0.95–1.34)

1.14

(1.08–1.21)

5%

1 time

(N = 969,925)

1.16

(1.11–1.20)

0.77

(0.61–0.96)

1.13

(1.03–1.23)

1.29

(1.18–1.41)

1.54

(1.40–1.70)

1.17

(1.11–1.23)

1.18

(0.93–1.49)

1.05

(0.93–1.18)

1.26

(1.13–1.41)

1.17

(1.11–1.23)

≥ 2 times

(N = 414,193)

1.23

(1.16–1.29)

1.07

(0.51–2.26)

0.96

(0.80–1.15)

1.26

(1.10–1.44)

1.59

(1.37–1.85)

1.30

(1.21–1.41)

1.50

(0.62–3.60)

1.03

(0.81–1.32)

1.27

(1.05–1.54)

1.30

(1.21–1.41)

7%

1 time

(N = 516,383)

1.22

(1.17–1.28)

None

1.02

(0.83–1.24)

1.25

(1.14–1.37)

1.58

(1.45–1.72)

1.22

(1.14–1.30)

None

0.88

(0.65–1.19)

1.31

(1.17–1.48)

1.22

(1.14–1.30)

≥ 2 times

(N = 115,333)

1.48

(1.36–1.61)

None

1.07

(0.34–3.31)

1.18

(0.93–1.50)

1.75

(1.50–2.05)

1.53

(1.35–1.74)

None

0.90

(0.13–6.37)

1.56

(1.14–2.14)

1.53

(1.35–1.74)

10%

1 time

(N = 183,968)

1.35

(1.26–1.44)

None

None

1.02

(0.76–1.39)

1.67

(1.53–1.82)

1.36

(1.24–1.49)

None

None

1.19

(0.81–1.76)

1.36

(1.24–1.49)

≥ 2 times

(N = 21,385)

2.04

(1.72–2.42)

None

None

None

2.48

(2.08–2.95)

1.91

(1.49–2.45)

None

None

None

1.91

(1.49–2.45)

  1. BMI, body mass index; BW, body weight; VIM, variability independent of the mean; Q, quartile
  2. Bolds are statistically significant
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Alzheimer's Research & Therapy

ISSN: 1758-9193