Fig. 6

Effect of SV2A on Aβ pathology in APP/PS1 mice. (a) Fluorescence intensity of 6E10 in hippocampal regions of SV2A overexpressing APP/PS1 mice and control APP/PS1 mice. (b) Fluorescence intensity of 6E10 in cortical regions of SV2A overexpressing APP/PS1 mice and control APP/PS1 mice. (c) Quantification of amyloid plaques per mm² area, amyloid plaque size (µm²), and the ratio of fluorescence intensity of 6E10 to DAPI in brain sections. AAV-SV2Aoe APP/PS1 mice group, n = 3; AAV-Con APP/PS1 mice group, n = 3; 3 fields of view per group. (d) The serum levels of Aβ40 in SV2A overexpressing APP/PS1 mice and control mice. (e) The serum levels of Aβ42 in SV2A overexpressing APP/PS1 mice and control mice. Scale bar: 50 μm. Data were presented as mean ± SD. All dot plots: t-test. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001