Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging

Table 2 Cortical regions showing significant associations between anti-HSV-1 IgG levels and Aβ load

Positive correlations	Extent of change (mm²)	MNI	R²	F_11,53	\({f}_{local}^{2}\)	CI_95%	BF₁₀
L rostral middle frontal (p_cluster= 0.0002)	6025	-42 35 22	0.13	9.8	0.16^M	0.008–0.52	14^S
R anterior cingulate (p_cluster= 0.00002)	3219	4 20 20	0.18	13.6	0.19^M	0.07–0.44	35^VS
R inferior temporal (p_cluster= 0.008)	2981	57 − 39 -22	0.18	13.7	0.19^M	0.02–0.61	39^VS

MNI coordinates are in MNI152 space. Local effect size (f²_local): ^M moderate. CI_95%: 95% confidence interval. BF₁₀: Bayes factor derived from Bayesian linear regression analyses. The superscript of the BF₁₀ indicates the qualitative interpretation of the magnitude of evidence in favor of the alternative hypothesis as opposed to the null hypothesis: ^S strong; ^VS very strong. L: left; R: right

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