Fig. 2From: A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factorsA PGRN plasma concentrations in GRN mutation carriers (GRN) and non-mutation carriers (Non-GRN). Cut-off determined using the optimal Youden’s index. B PGRN CSF concentrations in GRN mutation carriers (GRN) and non-mutation carriers (non-GRN). Cut-off determined using the optimal Youden’s index. C Serum PGRN concentrations in both GRN mutation carriers (GRN) and non-mutation carriers (non-GRN). Cut-off determined using the optimal Youden’s index. Error bars indicate standard error of the mean (SEM)Back to article page