Fig. 1From: A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factorsA Plasma PGRN concentrations across individual GRN variants. Light grey shading denotes exonic regions and darker grey shading intronic regions. Dotted lines denote previously published with cut-offs for pathogenicity 61.55 [14] and 71.00 [30] and average non-GRN plasma PGRN concentration (156.02 ng/mL). Different colours represent different types of variants. B Plasma PGRN concentrations by mutation type. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, two-tailed Mann–Whitney Test. Small sample sizes in deletions (n = 4) and missense in signal peptide (n = 10). C Plasma PGRN concentrations in different GRN missense variants. Dotted lines denote cut-offs previously published of 61.55 [14] and 71.00 [30]. Error bars indicate standard error of the mean (SEM)Back to article page