Table 3 Diagnostic accuracy of the proposed criteria in classifying prodromal FTD from healthy controls

Whole group (n = 398)

 Core criteria

0.79 (0.73–0.84)

56.5%

92.8%

76.5%

83.8%

 Plasma NfL^a

0.68 (0.59–0.77)

63.0%

66.1%

40.3%

83.2%

 Anterior cingulate^b

0.69 (0.62–0.77)

55.1%

77.6%

42.7%

85.1%

 Core criteria + NfL^a

0.84 (0.76–0.91)

69.6%

86.4%

65.3%

88.5%

 Core criteria + anterior cingulate^b

0.82 (0.76–0.89)

64.7%

90.6%

67.7%

89.4%

 Core criteria + NfL + anterior cingulate^a

0.90 (0.82–0.97)

81.8%

93.0%

77.1%

94.7%

EYO < 5 years (n = 139)

 Core criteria

0.85 (0.78–0.93)

80.0%

87.4%

78.4%

88.4%

 Plasma NfL^c

0.65 (0.49–0.81)

60.0%

69.7%

47.4%

79.3%

 Anterior cingulate^d

0.72 (0.61–0.83)

45.2%

89.2%

66.7%

77.3%

 Core criteria + NfL^c

0.92 (0.83–1.00)

80.0%

93.9%

85.7%

91.2%

 Core criteria + anterior cingulate^d

0.92 (0.86–0.98)

83.3%

87.5%

75.8%

91.8%

 Core criteria + NfL + anterior cingulate^c

0.97 (0.93–1.00)

91.7%

96.4%

91.7%

96.4%