Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

Table 1 Demographic and clinical characteristics of the prodromal FTD group and healthy control group

	Prodromal carriers (n = 117)	Healthy non-carriers (n = 281)	p value
Age, years	50.1 (39.4–56.9)	44.7 (37.8–56.6)	0.016
Sex, n female (%)	70 (59.8)	158 (56.2)	0.578
Education, years	15 (12–16)	15 (12–16)	0.858
Handedness (R:L:A)	105:10:2	258:19:4	0.702
CDR plus NACC - SOB	0.5 (0.5–1.5)	0.0 (0.0–0.0)
Genetic status, n (%)^b			0.189
*GRN*	44 (37.6)	99 (35.2)
*C9orf72*	51 (43.6)	116 (41.3)
*MAPT*	22 (18.8)	59 (21.0)
Neuropsychological tests
TMT-A	25.0 (19.0–33.0)	24.9 (19.0–31.0)	0.468
TMT-B	61.0 (45.0–80.0)	57.1 (47.0–72.8)	0.437
Semantic fluencies	23.0 (20.0–28.0)	24.0 (20.0–27.0)	0.784
Phonemic fluencies	40.0 (30.0–49.8)	41.0 (31.0–50.0)	0.581
Mini-SEA	25.6 (24.0–27.0)	26.0 (24.0–27.0)	0.444
Boston naming	28.0 (26.0–29.0)	28.0 (27.0–29.0)	0.097
Modified camel and cactus test	30.4 (29.0–31.0)	30.4 (29.2–31.0)	0.953
Plasma NfL, pg/mL	9.7 (6.7–15.9)	7.4 (5.0–10.6)	< 0.001
Anterior cingulate cortex^a	0.75 (0.25–1.25)	0.50 (0.00–0.50)	< 0.001

Data are median (interquartile range (IQR)) or n (%). p values were calculated by the Mann-Whitney U test, χ² test, or Fisher’s exact test, as appropriate
R right-handed, L left-handed, A ambidextrous, CDR plus NACC – SOB CDR® Dementia Staging Instrument plus National Alzheimer’s Coordinating Centre behavior and language domains sum of boxes, NfL neurofilament light
^aSee text for details
^bFor healthy non-carriers, the number of participants in each genetic group represents healthy participants with a family member with that particular genetic variant

ISSN: 1758-9193