Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance

Table 3 Significant pathways identified by Approach 2 (candidate gene enrichment analyses of summary gene associations from discovery cohorts)

	PAR-dr				WL-dr
*Gene set*	*Size*	*Effect*	SE	*Path_p*_Eǂ	*Effect*	SE	*Path_p*_E ǂ
Type 1 diabetes	44	13.43%	0.69%	4.98E − 10	26.74%	1.10%	6.72E − 18
PSMD4 targets	73	9.38%	0.53%	2.13E − 10	18.64%	0.85%	2.56E − 18
Graft-versus-host disease	42	14.08%	0.70%	3.71E − 10	28.04%	1.13%	3.56E − 18
Allograft rejection	38	15.58%	0.75%	1.97E − 10	31.04%	1.18%	8.87E − 19
Antigen processing and presentation	89	6.53%	0.49%	3.80E − 08	12.97%	0.77%	6.14E − 14
Viral myocarditis	73	8.01%	0.54%	1.14E − 08	15.90%	0.85%	5.13E − 15

This table displays pathways that were significantly enriched for memory-associated genes using Approach 2 and USGSA on the discovery cohorts. Candidate gene set enrichment analyses were run on 69 and 173 memory-associated genes for PAR-dr and WL-dr, respectively. Please refer to the legend of Table 1 for descriptions of Gene Set, Size, PAR-dr, and WL-dr. Effect is the increased probability of a memory-associated gene to be from the specified pathway versus a random gene. SE is the standard error of the effect estimate; Path_p_Eǂ is the exact pathway p-value based on the hypergeometric distribution; Path_p_A, the adjusted pathway p-value based on 10,000 permutations, took values “ < 0.001” for all displayed gene sets and outcomes and was omitted from the table

ISSN: 1758-9193