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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance

Fig. 3

A Relationship between the strength ((− log 10 (p-values)) of verbal declarative memory single-variant associations and being in high linkage disequilibrium (r2 > 0.80) with eQTLs and meQTLs across tissues. The shapes with dotted lines represent the odds ratios of being in linkage disequilibrium with an eQTL or meQTL given a one unit increase in SNP-memory association significance (p-value decreasing by a power of 10). The length of dotted line denotes the 95% confidence intervals of the odds ratios. B Relationship between the strength ((− log 10 (U-score)) of verbal declarative memory gene associations and regulation by known transcription factors and microRNAs. The shapes with dotted lines represent the odds ratios of being regulated by a transcription factor or microRNA given a one unit increase in gene association significance (U-score decreasing by a power of 10). The length of dotted line denotes the 95% confidence intervals of the odds ratios. C Relationship between the strength ((− log 10 (U-score)) of verbal declarative memory gene associations and annotation as an immunity gene. The heights of the bars represent the odds ratios of being an annotated immune gene given a one unit increase in gene association significance (U-score decreasing by a power of 10). The bars denote the 95% confidence intervals of the odds ratios

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